Drug General Information (ID: DDIS03QN8V)
Drug Name			Theophylline		Drug Info		Clonazepam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Bronchodilators				Anticonvulsants
Structure

Mechanism of Theophylline-Clonazepam Interaction (Severity Level: Minor)
Antagonize the effect of antiepileptic agents Click to Show/Hide Mechanism Graph
Drug Name		Theophylline				Clonazepam
Mechanism		Lower seizure threshold				Antiepileptic agent
Key Mechanism Factor 1
		Factor Name		Antiepileptic agents
		Factor Description		The beneficial effects of antiepileptic drugs may be reduced, leading to an increase in seizure frequency or duration.
Mechanism Description		Antagonize the effect of Clonazepam when combined with Theophylline

References
1	Gallen JS "Aminophylline reversal of midazolam sedation." Anesth Analg 69 (1989): 268
2	Bonfiglio MF, Dasta JF "Clinical significance of the benzodiazepine-theophylline interaction." Pharmacotherapy 11 (1991): 85-7
3	Tuncok Y, Akpinar O, Guven H, Akkoclu A "The effects of theophylline on serum alprazolam levels." Int J Clin Pharmacol Ther 32 (1994): 642-5