Details of Drug

Drug General Information (ID: D1054)
Drug Name	Mexiletine
Drug Type	Small molecule
Drug Synonymous	Mexiletene; Mexiletina; Mexiletinum; Mexilitine; Mexityl; Mexiletine HCL; KO1173; KO-1173; KOE-1173; Mexiletina [INN-Spanish]; Mexiletine (INN); Mexiletine [INN:BAN]; Mexiletinum [INN-Latin]; Mexitil (TN); (+-)-1-(2,6-dimethylphenoxy)propan-2-amine; (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane; 1-(2',6'-Dimethylphenoxy)-2-aminopropane; 1-(2,6-Dimethylphenoxy)-2-propanamine; 1-(2,6-dimethylphenoxy)propan-2-amine; 1-Methyl-2-(2,6-xylyloxy)ethylamine; 1-methyl-2-(2,6-xylyloxy)ethanamine; 2-(2-Aminopropoxy)-1,3-DiMethyl-Benzene Hydrochloride; 2-(2-aminopropoxy)-1,3-dimethylbenzene Click to Show/Hide
Disease Class	BC71: Ventricular tachyarrhythmia
Therapeutic Class	Antiarrhythmic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C11H17NO
InChI	1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
InChIKey	VLPIATFUUWWMKC-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C(=CC=C1)C)OCC(C)N
External Link
	Pubchem ID	4178
	CAS Number	31828-71-4
	CHEBI ID	6916
	TTD ID	D0X0RI
	VARIDT ID	DR00695

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM029 Altered urine pH BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM069 Increased risk of lowers seizure threshold BM076 Increased risk of prolong QT interval BM078 Increased risk of rapid heart rate
Relation Graph

Full list of drugs interacting with Mexiletine
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[16], [30], [150], [151]
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[16], [85]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[53], [55], [60]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[30], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
	CYP450 enzyme inhibition					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1201		Oxtriphylline	C12H21N5O3	656652	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[29], [30], [39]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47]
D1570		Theophylline	C7H8N4O2	2153	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[64], [65]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[66]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[69]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[70]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[71]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[74]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[75]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[76]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[79]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[29], [30], [80]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[29], [81], [82]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[30], [83], [84]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[86]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[87]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[29], [30], [88], [89]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[90]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[91]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[92], [93]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[94]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[29], [30], [95]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[30], [98]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[99], [100], [101], [66], [102], [103], [104]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[113]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[114]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[30], [118]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[122]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[29], [30], [123]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[124]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[125]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[126]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[99], [100], [101], [66], [102], [103], [104]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[127], [128]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[30], [131]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[133]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[30], [136], [137]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[138]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[99], [100], [101], [66], [102], [103], [104]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[139]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[30], [88], [140]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[141]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[142], [143], [144], [145]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[47]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[146], [147], [138], [148], [149]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[152]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[153], [154]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[30], [155]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[156], [157]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[156], [157]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[156], [157]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[156], [157]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[156], [157]
	CYP450 enzyme induction					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[96]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[97]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[96]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[96]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[134], [135]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[96]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[30], [158]
Affected excretion pathways
	Altered urine pH					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[132]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[132]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[132]
D0111		Ascorbic acid	C6H8O6	54670067	Minor		Inter Info	[132]
D1022		Methionine	C5H11NO2S	6137	Minor		Inter Info	[132]
D0070		Ammonium chloride	ClH4N	25517	Minor		Inter Info	[132]
D1086		Monopotassium phosphate	H2KO4P	516951	Minor		Inter Info	[132]
D1486		Sodium phosphate, monobasic	NA	NA	Minor		Inter Info	[132]
Pharmacodynamic additive effects
	Increased risk of atrioventricular block					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[30], [67], [68]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[30], [77], [78]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[115]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[30], [77], [78]
	Increased risk of bradycardia					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[116], [117]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[29], [68]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[116], [117]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[34], [35], [36], [37], [38]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[34], [35], [36], [37], [38]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[48], [27], [26], [49]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[72], [73]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[29], [30]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[105], [106], [107], [108], [109], [110], [111], [112]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[119], [120], [121]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[129], [130], [30]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[129], [30], [130]
	Increased risk of prolong QT interval					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[16], [29], [30], [31], [32], [33]
	Increased risk of rapid heart rate					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0101		Arbutamine	C18H23NO4	60789	Major		Inter Info	[11], [12], [13]

References
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50	Product Information. Actemra (tocilizumab). Genentech, South San Francisco, CA.
51	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
52	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
53	Product Information. Cosentyx (secukinumab). Novartis Pharmaceuticals, East Hanover, NJ.
54	Product Information. Gamifant (emapalumab). Sobi Inc, Ardmore, PA.
55	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
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122	Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.
123	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
124	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
125	Product Information. Ocaliva (obeticholic acid). Intercept Pharmaceuticals, Inc., New York, NY.
126	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
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138	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
139	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
140	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
141	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
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152	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
153	Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
154	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
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