Drug General Information (ID: DDIPSJL1YE)
  Drug Name Ascorbic acid Drug Info Mexiletine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Vitamins Antiarrhythmic Agents
  Structure

 Mechanism of Ascorbic acid-Mexiletine Interaction (Severity Level: Minor)
     Altered urine pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Ascorbic acid Mexiletine
      Mechanism Urine acidifier Urine pH sensitive
      Key Mechanism Factor 1
Factor Name Urine pH
Factor Description The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
      Mechanism Description
  • Altered elimination of Mexiletine caused by Ascorbic acid mediated altered urine pH

References
1 Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4. [PMID: 6626420]