Details of Drug

Details of Drug

 Drug General Information (ID: D0111)
  Drug Name
Ascorbic acid
  Drug Type Small molecule
  Drug Synonymous
l-ascorbic acid; vitamin C; 50-81-7; L(+)-Ascorbic acid; Ascorbicap; Cevitamic acid; Ascoltin; Hybrin; Secorbate; Proscorbin; Lemascorb; Ascorteal; Ascorbajen; Vitascorbol; Vitamisin; Natrascorb; Citriscorb; Cescorbat; Ascorbutina; Testascorbic; Cevitamin; Cetemican; Allercorb; Vitacimin; Roscorbic; Laroscorbine; Viscorin; Redoxon; Cenetone; Cegiolan; Cebicure; Ascorvit; Viforcit; Concemin; Cevital; Cergona; Cemagyl; Cebione; Cantaxin; Ascorin; Vitacee; Vicelat; Cevimin; Cetamid; Cenolate; Celaskon; Vitacin; Adenex; Ascorb; Ascorbicab; Ascorbicin; Ascorbinsaeure; Cantan; Cebid; Cebion; Cecon; Ceglion; Celin; Cemill; Cereon; Cetebe; Cevalin; Cevatine; Cevex; Cevibid; Cevitan; Cevitex; Cewin; Ciamin; Cipca; Colascor; Cortalex; Duoscorb; Ferancee; Hicee; Magnorbin; Ribena; Scorbacid; Semidehydroascorbate; Sodascorbate; Stuartinic; Sunkist; Tolfrinic; Vitace; Xitix; Acid Ascorbic; Acide ascorbique; Acido ascorbico; Acidum ascorbicum; Acidum ascorbinicum; Antiscorbic vita min; Antiscorbic vitamin; Antiscorbutic factor; Antiscorbutic vitamin; Ascorbyl radical; Catavin C; Ce lent; Component of Cortalex; Component of Endoglobin Forte; Component of Ferancee; Davitamon C; Ferrous ascorbate; Kyselina askorbova; Kyselina askorbova [Czech]; Magnesium Ascorbicum; Monodehydroascorbic acid; Natrascorb injectable; Oral Vitamin C; Planavit C; Roscorbi c; Vicomin C; Acide ascorbique [INN-French]; Acido ascorbico [INN-Spanish]; Acidum ascorbicum [INN-Latin]; Arco-cee; Ascoltin (TN); Ascorbic Acid, Monosodium Salt; Ascorbicap (TN); C-Level; C-Long; C-Quin; C-Span; C-Vimin; Cee-Caps TD; Cee-Vite; Cee-caps td; Cetane-Caps TC; Cetane-Caps TD; Cevi-Bid; Component of E and C-Level; IDO-C; Iron(II) ascorbate; Iron-ascorbic acid complexes; L-Ascorbic acid; L-Lyxoascorbic acid; L-Xyloascorbic acid; L-ascorbic acid; Liqui-Cee; Meri-C; Sodium Ascorbate (Ascorbic Acid); Vitamin-C; Ascorbic acid [BAN:INN:JAN]; Ascorbic acid [INN:BAN:JAN]; CE-VI-Sol; Ce-Mi-Lin; Dora-C-500; L-3-Ketothreohexuronic acid lactone; L-3-ketothreohexuronic acid; L-Ascorbic acid, free radical form; Ascor-bid; Ascorbic acid (JP15/USP/INN); Ascor-BID; L-(+)-Ascorbic Acid; L-threo-Hex-2-enonic acid, gamma-lactone; L-threo-hex-1-eofuranos-3-ulose; L-threo-hex-2-enono-1,4-lactone; (2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one; (2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one; (5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one; 2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one; 3-Keto-L-gulofuranolactone; 3-Oxo-L-gulofuranolactone; 3-Oxo-L-gulofuranolactone (enol form); [14C]ascorbic acid
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  Disease Class 5B55-5B5F: Vitamin deficiency; GC08: Urinary tract infection
  Therapeutic Class Vitamins
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C6H8O6
  InChI 1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
  InChIKey CIWBSHSKHKDKBQ-JLAZNSOCSA-N
  Canonical SMILES C(C(C1C(=C(C(=O)O1)O)O)O)O
  External Link
Pubchem ID 54670067
CAS Number 50-81-7
CHEBI ID 29073
TTD ID D07AHW
INTEDE ID DR0144
VARIDT ID DR00289

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM005  Affected excretion pathways
AM007  Pharmacodynamic antagonistic effects
BM005  Altered gastric pH
BM009  Altered absorption (Unspecific)
BM029  Altered urine pH
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Ascorbic acid
      Affected gastrointestinal absorption
   Altered gastric pH Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0074
 
Amphetamine
 
C9H13N
 
3007 
Moderate    Inter Info   
[3]
D0165
 
Benzphetamine
 
C17H21N
 
5311017 
Moderate    Inter Info   
[3]
D0465
 
Dextroamphetamine
 
C9H13N
 
5826 
Moderate    Inter Info   
[3]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[3]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Moderate    Inter Info   
[7], [3], [8]
   Altered absorption (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[1], [2]
D1511
 
Sucralfate
 
C12H54Al9O55S8
 
121494085 
Moderate    Inter Info   
[1], [2]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Minor    Inter Info   
[14]
      Affected excretion pathways
   Altered urine pH Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0579
 
Ephedrine
 
C10H15NO
 
9294 
Minor    Inter Info   
[9], [10], [11]
D0580
 
Ephedrine (nasal)
 
C10H15NO
 
9294 
Minor    Inter Info   
[9], [10], [11]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Minor    Inter Info   
[12]
D1054
 
Mexiletine
 
C11H17NO
 
4178 
Minor    Inter Info   
[13]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Minor    Inter Info   
[9], [10], [11]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0193
 
Bortezomib
 
C19H25BN4O4
 
387447 
Moderate    Inter Info   
[4], [5], [6]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Fairweather-Tait S, Hickson K, McGaw B, Reid M "Orange juice enhances aluminium absorption from antacid preparation." Eur J Clin Nutr 48 (1994): 71-3. [PMID: 8200332]
3 Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
4 Zou W, Yue P, Lin N, et al. "Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells." Clin Cancer Res 12 (2006): 273-80
5 Bannerman B, Xi L, Jones M, et al "Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea." Cancer Chemother Pharmacol 68 (2011): 1145-54
6 Catley L, Anderson KC "Velcade and vitamin C: too much of a good thing?" Clin Cancer Res 12 (2006): 3-4
7 Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
8 Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
9 Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4. [PMID: 7438686]
10 Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7. [PMID: 5541135]
11 Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]
12 Hertrampf R, Gundert-Remy U, Beckmann J, et al "Elimination of flecainide as a function of urinary flow rate and pH." Eur J Clin Pharmacol 41 (1991): 61-3. [PMID: 1782979]
13 Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4. [PMID: 6626420]
14 Gonzalez JP, Valdivieso A, Calvo R, Rodriquezsasiain JM, Jimenez R, Aguirre C, Dusouich P "Influence of vitamin c on the absorption and first pass metabolism of propranolol." Eur J Clin Pharmacol 48 (1995): 295-7. [PMID: 7589058]