Drug General Information (ID: DDI41JOPSN)
Drug Name			Ascorbic acid		Drug Info		Benzphetamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Cns Stimulants
Structure

Mechanism of Ascorbic acid-Benzphetamine Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Ascorbic acid				Benzphetamine
Mechanism		Gastric acidifier				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Benzphetamine due to altered gastric pH caused by Ascorbic acid

Recommended Action
Management		Patients receiving an amphetamine in combination with gastrointestinal acidifying agents should be monitored for potentially diminished pharmacologic response to the amphetamine.

References
1	Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.