Drug General Information (ID: D0165)
  Drug Name
Benzphetamine
  Drug Type Small molecule
  Drug Synonymous
Benzaphetamine; Benzfetamina; Benzfetamine; Benzfetaminum; Benzofetamina; Benzphetaminum; Benzylamphetamine; Benzfetamina [DCIT]; Benzfetamina [Spanish]; Benzfetaminum [Latin]; U 0441; Benzfetamina [INN-Spanish]; Benzfetamine (INN); Benzfetamine [INN:BAN]; Benzfetaminum [INN-Latin]; Benzofetamina [INN-Spanish]; Benzphetaminum [INN-Latin]; D-Benzphetamine; Didrex (TN); N-Benzylmethamphetamin; N-Benzyl-N,alpha-dimethylphenethylamine; N,alpha-Dimethyl-N-(phenylmethyl)benzeneethanamine; D-N-Methyl-N-benzyl-beta-phenylisopropylamine; N,alpha-Dimethyl-N-(phenylmethyl)-benzeneethanamine; N-Benzyl-N-methyl-1-phenyl-2-propanamine; N-benzyl-N-methyl-1-phenylpropan-2-amine; N-methyl-1-phenyl-N-(phenylmethyl)propan-2-amine; Benzeneethanamine, N,alpha-dimethyl-N-(phenylmethyl)-, (+)-(9CI); (+)-N,alpha-dimethyl-N-(phenylmethyl)-benzeneethanamine; (+)-N-benzyl-N,alpha-dimethylphenethylamine; (+)-benzphetamine; (2S)-N-benzyl-N-methyl-1-phenylpropan-2-amine; (R,S)-N-Benzyl-alpha,N-dimethylphenethylamin; (S)-(+)-N-benzyl-N,alpha-dimethylphenethylamine; (S)-(+)-benzphetamine; (S)-benzphetamine; (alphaS)-N,alpha-dimethylphenethylamine
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  Disease Class 5B80-5B81: Obesity
  Therapeutic Class Cns Stimulants
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C17H21N
  InChI 1S/C17H21N/c1-15(13-16-9-5-3-6-10-16)18(2)14-17-11-7-4-8-12-17/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1
  InChIKey YXKTVDFXDRQTKV-HNNXBMFYSA-N
  Canonical SMILES CC(CC1=CC=CC=C1)N(C)CC2=CC=CC=C2
  External Link
Pubchem ID 5311017
CAS Number 156-08-1
CHEBI ID 3044
TTD ID D0T5UL
INTEDE ID DR0198

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM005  Altered gastric pH
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM024  Competitive inhibition of metabolic enzyme
BM029  Altered urine pH
BM038  Additive CNS depression effects
BM041  Additive hypertensive effects
BM046  Additive serotonergic effects
BM061  Increased risk of hyperpyrexia
BM064  Increased risk of hypoglycemia
BM069  Increased risk of lowers seizure threshold
BM081  Increased risk of ventricular arrhythmias
BM083  Potentiated the pharmacological effects (Unspecific)
BM089  Antagonize the effect of antihypertensive agents
BM093  Antagonize the effect of dopaminergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Benzphetamine
      Affected gastrointestinal absorption
   Altered gastric pH Drug Num:  9
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0111
 
Ascorbic acid
 
C6H8O6
 
54670067 
Moderate    Inter Info   
[49]
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[48]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[48]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[48]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[48]
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[48]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[48]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Moderate    Inter Info   
[48]
D0729
 
Glutamic acid
 
C5H9NO4
 
33032 
Moderate    Inter Info   
[49]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[31]
D1821
 
Iobenguane (I-123)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[123], [124], [125]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  8
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Moderate    Inter Info   
[98], [99]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[100]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Moderate    Inter Info   
[98], [99]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[113]
D0732
 
Glycerol phenylbutyrate
 
C33H38O6
 
10482134 
Moderate    Inter Info   
[20], [122]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[124], [129], [130]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Moderate    Inter Info   
[166]
   Competitive inhibition of metabolic enzyme Drug Num:  3
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Moderate    Inter Info   
[161], [162]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[161], [162]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[161], [162]
      Affected excretion pathways
   Altered urine pH Drug Num:  9
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0070
 
Ammonium chloride
 
ClH4N
 
25517 
Moderate    Inter Info   
[105], [49], [106]
D0886
 
Lactic acid
 
C3H6O3
 
612 
Moderate    Inter Info   
[126], [127], [128]
D1020
 
Methenamine
 
C6H12N4
 
4101 
Moderate    Inter Info   
[105], [49], [106]
D1086
 
Monopotassium phosphate
 
H2KO4P
 
516951 
Moderate    Inter Info   
[105], [49], [106]
D1319
 
Potassium citrate
 
C6H5K3O7
 
13344 
Moderate    Inter Info   
[126], [157], [105], [158], [127], [128]
D1478
 
Sodium acetate
 
C2H3NaO2
 
517045 
Moderate    Inter Info   
[126], [157], [105], [158], [127], [128]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[126], [157], [105], [158], [127], [128]
D1483
 
Sodium citrate
 
C6H5Na3O7
 
6224 
Moderate    Inter Info   
[126], [157], [105], [158], [127], [128]
D1654
 
Tromethamine
 
C4H11NO3
 
6503 
Moderate    Inter Info   
[126], [157], [105], [158], [127], [128]
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[91], [112], [89]
   Additive hypertensive effects Drug Num:  49
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Major    Inter Info   
[20], [21], [22]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Major    Inter Info   
[20], [21], [22]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Major    Inter Info   
[23], [24], [25]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[23], [24], [25]
D0600
 
Esketamine
 
C13H16ClNO
 
182137 
Major    Inter Info   
[29], [30]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Major    Inter Info   
[23], [24], [25]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[23], [24], [25]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Major    Inter Info   
[23], [24], [25]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Major    Inter Info   
[23], [24], [25]
D1708
 
Vortioxetine
 
C18H22N2S
 
9966051 
Major    Inter Info   
[23], [24], [25]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[23], [24], [25]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Major    Inter Info   
[23], [24], [25]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Major    Inter Info   
[23], [24], [25]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Major    Inter Info   
[23], [24], [25]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Major    Inter Info   
[23], [24], [25]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[95], [96], [97]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[95], [96], [97]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[50], [52], [107]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[95], [96], [97]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[95], [96], [97]
D0517
 
Dopamine
 
C8H11NO2
 
681 
Moderate    Inter Info   
[50], [52], [107]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[95], [96], [97]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[95], [96], [97]
D0538
 
Droxidopa
 
C9H11NO5
 
92974 
Moderate    Inter Info   
[111]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[50], [52], [107]
D0857
 
Isometheptene
 
C9H19N
 
22297 
Moderate    Inter Info   
[50], [52], [107]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[50], [52], [107]
D0921
 
Levonordefrin
 
C9H13NO3
 
164739 
Moderate    Inter Info   
[50], [52], [107]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[50], [52], [107]
D1002
 
Mephentermine
 
C11H17N
 
3677 
Moderate    Inter Info   
[50], [52], [107]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[50], [52], [107]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Moderate    Inter Info   
[50], [52], [107]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[37], [59], [38], [20], [61], [39], [40], [62], [42], [43], [63], [44], [64], [65], [45], [70], [46], [71], [159], [53], [54], [56], [160], [57], [58]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[50], [52], [107]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[50], [52], [107]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[50], [52], [107]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[50], [52], [107]
D0510
 
Dobutamine
 
C18H23NO3
 
36811 
Moderate    Inter Info   
[50], [52], [107]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[95], [96], [97]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[50], [52], [107]
D1013
 
Metaraminol
 
C9H13NO2
 
5906 
Moderate    Inter Info   
[50], [52], [107]
D1027
 
Methoxamine
 
C11H17NO3
 
6082 
Moderate    Inter Info   
[50], [52], [107]
D1153
 
Norepinephrine
 
C8H11NO3
 
439260 
Moderate    Inter Info   
[50], [52], [107]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[95], [96], [97]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[50], [52], [107]
D1276
 
Phenylephrine
 
C9H13NO2
 
6041 
Moderate    Inter Info   
[50], [52], [107]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[95], [96], [97]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Moderate    Inter Info   
[50], [52], [107]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[95], [96], [97]
   Additive serotonergic effects Drug Num:  7
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Moderate    Inter Info   
[92], [93], [94]
D0466
 
Dextromethorphan
 
C18H25NO
 
5360696 
Moderate    Inter Info   
[92], [93], [94]
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Moderate    Inter Info   
[92], [93], [94]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[92], [93], [94]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Moderate    Inter Info   
[92], [93], [94]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Moderate    Inter Info   
[92], [93], [94]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[92], [93], [94]
   Increased risk of hyperpyrexia Drug Num:  8
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[37], [59], [38], [29], [20], [60], [61], [39], [40], [62], [41], [42], [43], [63], [44], [64], [65], [66], [67], [68], [45], [69], [70], [46], [71], [72], [73], [74], [47], [48], [75], [76], [49], [50], [77], [78], [79], [51], [80], [81], [52], [82], [53], [83], [54], [55], [84], [85], [56], [57], [86], [87], [88], [58]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1455
 
Selegiline
 
C13H17N
 
26757 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
   Increased risk of hypoglycemia Drug Num:  37
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[89], [90], [91]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[89], [90], [91]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[89], [90], [91]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[89], [90], [91]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[89], [90], [91]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[89], [90], [91]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[89], [90], [91]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[89], [90], [91]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[89], [90], [91]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[89], [90], [91]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[89], [90], [91]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[89], [90], [91]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[89], [90], [91]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[89], [90], [91]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Moderate    Inter Info   
[89], [90], [91]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Moderate    Inter Info   
[89], [90], [91]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[89], [90], [91]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[89], [90], [91]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[89], [90], [91]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[89], [90], [91]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[89], [90], [91]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[89], [90], [91]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[89], [90], [91]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[89], [90], [91]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[89], [90], [91]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[89], [90], [91]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[89], [90], [91]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[89], [90], [91]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[89], [90], [91]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[89], [90], [91]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[89], [90], [91]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[89], [90], [91]
D1064
 
Miglitol
 
C8H17NO5
 
441314 
Moderate    Inter Info   
[89], [90], [91]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[89], [90], [91]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[89], [90], [91]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[89], [90], [91]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[89], [90], [91]
   Increased risk of lowers seizure threshold Drug Num:  8
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[32], [33], [34], [35], [36]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[32], [33], [34], [35], [36]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[103], [104]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[114], [115], [116], [117], [118], [119], [120], [121]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[155], [156], [20]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[155], [156], [20]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[155], [156], [20]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[168], [169], [170]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1577
 
Thyroid, porcine
 
NA
 
NA
Moderate    Inter Info   
[163], [164], [165]
D0925
 
Levothyroxine
 
C15H11I4NO4
 
5819 
Moderate    Inter Info   
[163], [164], [165]
D0934
 
Liothyronine
 
C15H12I3NO4
 
5920 
Moderate    Inter Info   
[163], [164], [165]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  9
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0457
 
Dexfenfluramine
 
C12H16F3N
 
66265 
Major    Inter Info   
[26], [27], [28]
D0486
 
Diethylpropion
 
C13H19NO
 
7029 
Major    Inter Info   
[26], [27], [28]
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Major    Inter Info   
[26], [27], [28]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Major    Inter Info   
[26], [27], [28]
D1262
 
Phendimetrazine
 
C12H17NO
 
30487 
Major    Inter Info   
[26], [27], [28]
D0641
 
Fenfluramine
 
C12H16F3N
 
3337 
Major    Inter Info   
[26], [27], [28]
D0981
 
Mazindol
 
C16H13ClN2O
 
4020 
Major    Inter Info   
[26], [27], [28]
D1270
 
Phentermine
 
C10H15N
 
4771 
Major    Inter Info   
[26], [27], [28]
D1281
 
Phenylpropanolamine
 
C9H13NO
 
26934 
Major    Inter Info   
[26], [27], [28]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  3
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0444
 
Deserpidine
 
C32H38N2O8
 
8550 
Moderate    Inter Info   
[108], [109], [110]
D0744
 
Guanethidine
 
C10H22N4
 
3518 
Moderate    Inter Info   
[108], [109], [110]
D0743
 
Guanadrel
 
C10H19N3O2
 
38521 
Moderate    Inter Info   
[108], [109], [110]
   Antagonize the effect of dopaminergic agents Drug Num:  16
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[101], [46], [102]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[131], [132], [167], [133], [135], [136], [137], [138], [139], [101], [140], [141], [142], [143], [144], [145], [48], [53], [102], [151], [152], [153], [154]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[131], [132], [133], [134], [135], [136], [137], [138], [139], [101], [140], [141], [46], [142], [143], [144], [145], [48], [146], [147], [49], [89], [148], [50], [149], [51], [94], [150], [53], [102], [151], [152], [153], [154]
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111 Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
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113 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
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122 Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
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124 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
125 Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.
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129 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
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146 Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.
147 Product Information. Desoxyn (methamphetamine) Abbott Pharmaceutical, Abbott Park, IL.
148 Product Information. Fastin (phentermine). SmithKline Beecham, Philadelphia, PA.
149 Product Information. Prelu-2 (phendimetrazine) Boehringer-Ingelheim, Ridgefield, CT.
150 Product Information. Tenuate (diethylpropion) Aventis Pharmaceuticals, Swiftwater, PA.
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155 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
156 Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
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159 Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
160 Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]
161 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
162 Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
163 Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
164 Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
165 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
166 Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
167 Capstick C, Checkley S, Gray J, Dawe S "Dystonia induced by amphetamine and haloperidol." Br J Psychiatry 165 (1994): 276. [PMID: 7953053]
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169 Cox R, Krupnick J, Bush N, Houpt A "Seizures caused by concomitant use of lindane and dextroamphetamine in a child with attention deficit hyperactivity disorder." J Miss State Med Assoc 41 (2000): 690-2. [PMID: 10974795]
170 Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.