Drug General Information (ID: DDIFROT07B)
Drug Name			Ascorbic acid		Drug Info		Aluminum hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Antacids
Structure

Mechanism of Ascorbic acid-Aluminum hydroxide Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ascorbic acid				Aluminum hydroxide
Mechanism		Increase absorption of aluminum				Aluminum-containing products
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Aluminum hydroxide caused by Ascorbic acid

Recommended Action
Management		Concomitant use of ascorbic acid in doses above the recommended dietary allowance with aluminum-containing products should be avoided in patients with renal failure. If higher doses of ascorbic acid are required, monitor for signs and symptoms of aluminum toxicity and consider monitoring serum phosphate levels.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Fairweather-Tait S, Hickson K, McGaw B, Reid M "Orange juice enhances aluminium absorption from antacid preparation." Eur J Clin Nutr 48 (1994): 71-3. [PMID: 8200332]