Drug General Information (ID: DDIWZJ6HV5)
Drug Name			Mexiletine		Drug Info		Nebivolol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antihypertensive Agents
Structure

Mechanism of Mexiletine-Nebivolol Interaction (Severity Level: Moderate)
Increased risk of atrioventricular block Click to Show/Hide Mechanism Graph
Drug Name		Mexiletine				Nebivolol
Mechanism		Delay atrioventricular conduction				Delay atrioventricular conduction
Key Mechanism Factor 1
		Factor Name		Atrioventricular block
		Factor Description		Atrioventricular block is a type of cardiac conduction block that occurs when the electrical signal from the atria to the ventricles is impaired. In an Atrioventricular block, this electrical signal is either delayed or completely blocked. When the signal is completely blocked, the ventricles produce their own electrical signal to control the heart rate. The heart rate produced by the ventricles is much slower than that produced by the sinus node.
Mechanism Description		Increased risk of atrioventricular block by the combination of Mexiletine and Nebivolol

Recommended Action
Management		Caution and monitoring for cardiac arrhythmias, bradycardia, and heart failure are recommended during concurrent therapy.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Bystolic (nebivolol). Forest Pharmaceuticals, St. Louis, MO.
3	Leopold G, Pabst J, Ungethum W, Buhring KU "Basic pharmacokinetics of bisoprolol, a new highly beta 1-selective adrenoceptor antagonist." J Clin Pharmacol 26 (1986): 616-21