Details of Drug

Drug General Information (ID: D1114)
Drug Name	Nebivolol
Drug Type	Small molecule
Drug Synonymous	Bystolic; Lobivon; Nebilet; Nebilong; Nebipill; Nebivololum; Nubeta; Nebivololum [Latin]; R 67555; Bystolic (TN); Nebicard-5;Nebilet (TN); Nebilong (TN); Nodon (TN); Nubeta (TN); PI-21858; R-67555; R65,824; Nebicard-5 (TN); Nebivolol (USAN/INN); Nebivolol [USAN:INN:BAN]; Alpha,alpha'-(Iminodimethylene)bis(6-fluoro-2-chromanmethanol); Alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol); Alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol; 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol; 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H25F2NO4
InChI	1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2
InChIKey	KOHIRBRYDXPAMZ-UHFFFAOYSA-N
Canonical SMILES	C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
External Link
	Pubchem ID	71301
	CAS Number	99200-09-6
	CHEBI ID	64019
	TTD ID	D0Z1UA

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM048 Increased risk of angioedema/anaphylactoid reactions BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM057 Increased risk of hyperglycemia BM062 Increased risk of hypertriglyceridemia BM064 Increased risk of hypoglycemia BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM089 Antagonize the effect of antihypertensive agents BM090 Antagonize the effect of bronchodilators BM101 Antagonize the effects of beta receptor blockers BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Nebivolol
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[105], [106], [103]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[105], [106], [103]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[51], [52], [106], [104], [105], [103]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
	Complex formation					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[239], [51], [52], [240], [241], [242]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D0877		Kaolin	Al2H4O9Si2	56841936	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D0049		Aluminum hydroxide	AlH3O3	10176082	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D0967		Magaldrate	AlHMgO5S+2	3086011	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [106]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1906		Thallous Chloride	ClTl	24642	Moderate		Inter Info	[51], [263], [264]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[149]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[158], [159], [160], [161], [162], [105], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[175], [176], [177]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[158], [159], [160], [161], [162], [105], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[158], [159], [160], [161], [162], [105], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[203]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[219]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[226]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[5]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[230]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[51], [52], [231]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[52], [232]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[233]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[52], [234]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[249]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[250]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[255]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[259]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[260]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[265]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[158], [159], [160], [161], [162], [105], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[272], [273], [274], [275], [175], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [177], [286], [287], [288], [289], [49], [290], [291], [292], [293], [294]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[307]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[308]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[158], [159], [160], [161], [162], [105], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[310], [311], [312], [313]
	CYP450 enzyme induction					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[86], [87], [88]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[84], [85], [86], [87], [88], [89]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[315]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[150], [151], [152], [153], [154], [155], [156], [157]
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[52], [51], [103], [104], [105], [106]
	Additive hypertensive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[132], [133], [134]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[132], [133], [134]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[132], [133], [134]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[132], [133], [134]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[132], [133], [134]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[132], [133], [134]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[269], [270]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[269], [270]
	Additive hypotensive effects					Drug Num: 164
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[45], [46], [47], [48], [49]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[61]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[63]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[64], [65], [66]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[75], [76], [77]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[64], [65], [66]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[78], [71], [79]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[64], [65], [66]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[64], [65], [66]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[78], [90], [91]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[92], [93], [94]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[64], [65], [66]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[127], [128]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[92], [93], [94]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[92], [93], [94]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[64], [65], [66]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[64], [65], [66]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[64], [65], [66]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[64], [65], [66]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[64], [65], [66]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[127], [128]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[64], [65], [66]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[64], [65], [66]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[64], [65], [66]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[64], [65], [66]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[64], [65], [66]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[64], [65], [66]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[64], [65], [66]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[64], [65], [66]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[64], [65], [66]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[64], [65], [66]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[64], [65], [66]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[51], [173], [174]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[64], [65], [66]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[64], [65], [66]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[64], [65], [66]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[64], [65], [66]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[64], [65], [66]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[64], [65], [66]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[64], [65], [66]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[64], [65], [66]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[64], [65], [66]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[64], [65], [66]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[52], [188], [189]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[64], [65], [66]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[64], [65], [66]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[193]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[64], [65], [66]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[64], [65], [66]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[199], [200], [201]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[199], [200], [201]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[61], [7], [202]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[64], [65], [66]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[64], [65], [66]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[64], [65], [66]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[52], [188], [189]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[64], [65], [66]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[199], [200], [201]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[64], [65], [66]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[127], [128]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[78], [90], [207]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[64], [65], [66]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[199], [200], [201]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[64], [65], [66]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[64], [65], [66]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[211]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[64], [65], [66]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[64], [65], [66]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[64], [65], [66]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[64], [65], [66]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[64], [65], [66]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[51], [214], [215]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[51], [52], [216]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[127], [128]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[64], [65], [66]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[64], [65], [66]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[64], [65], [66]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[64], [65], [66]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[223], [224], [225]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[64], [65], [66]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[51], [52], [228]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[51], [52], [228]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[51], [52], [228]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[127], [128]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[64], [65], [66]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[52], [247], [248]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[64], [65], [66]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[251], [252], [253]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[64], [65], [66]
D1183		Opium	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[64], [65], [66]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[64], [65], [66]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[258]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[199], [200], [201]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[52], [188], [189]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[64], [65], [66]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[266], [267], [248]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[64], [65], [66]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[64], [65], [66]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[64], [65], [66]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[64], [65], [66]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[64], [65], [66]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[64], [65], [66]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[268]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[199], [200], [201]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[199], [200], [201]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[64], [65], [66]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[64], [65], [66]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[199], [200], [201]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[64], [65], [66]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[199], [200], [201]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[199], [200], [201]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[223], [224], [225]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[64], [65], [66]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[64], [65], [66]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[64], [65], [66]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[127], [128]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[199], [200], [201]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[64], [65], [66]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[52], [188], [189]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[64], [65], [66]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[64], [65], [66]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[223], [224], [225]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[64], [65], [66]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[95], [96], [97], [98], [75], [99], [76], [100], [77], [101], [102]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[64], [65], [66]
D0711		Garlic	NA	NA	Minor		Inter Info	[325], [326]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[328], [329]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1783		Ethiodized oil	NA	NA	Moderate		Inter Info	[190], [191], [192]
D1787		Fluorescein	C20H12O5	16850	Moderate		Inter Info	[196], [197], [198]
D1791		Gadobenic acid	C22H28GdN3O11	9852779	Moderate		Inter Info	[51], [52], [173]
D1793		Gadodiamide	C16H26GdN5O8	153921	Moderate		Inter Info	[51], [52], [173]
D1795		Gadopentetic acid	C14H20GdN3O10	6857474	Moderate		Inter Info	[51], [52], [173]
D1797		Gadoteridol	C17H29GdN4O7	60714	Moderate		Inter Info	[51], [52], [173]
D1798		Gadoversetamide	C20H34GdN5O10	444013	Moderate		Inter Info	[51], [52], [173]
D1792		Gadobutrol	C18H31GdN4O9	6102852	Moderate		Inter Info	[51], [52], [173]
D1794		Gadofosveset trisodium	C33H38GdN3Na3O14P	73049652	Moderate		Inter Info	[51], [52], [173]
D1796		Gadoteric acid	C16H25GdN4O8	158536	Moderate		Inter Info	[51], [52], [173]
D1826		Iopanoic acid	C11H12I3NO2	3735	Moderate		Inter Info	[190], [191], [192]
D1915		Tyropanoic acid	C15H18I3NO3	5611	Moderate		Inter Info	[190], [191], [192]
	Increased risk of atrioventricular block					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[4], [5]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[50]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[52], [212], [213]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[52], [62], [217]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[236]
D1288		Pilocarpine	C11H16N2O2	5910	Moderate		Inter Info	[271]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[309], [213]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[52], [327]
	Increased risk of bradycardia					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0363		Clonidine	C9H9Cl2N3	2803	Major		Inter Info	[6], [7], [8]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[51], [52], [53]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[54], [55]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[51], [56]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[58], [59], [60]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[80], [81], [82], [83]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[135], [136], [137]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[178], [179], [180]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[178], [179], [180]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[184], [185], [186]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[184], [185], [186]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[208], [209], [210]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[218]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[220], [221]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[227]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[52], [229], [213]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[51], [235]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[237], [238]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[243]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[254]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[239], [51], [52], [256], [257]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[51], [213]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[237], [238]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[184], [185], [186]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[184], [185], [186]
	Increased risk of cardiac depression					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [62], [32], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[24], [194], [195]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[9], [112], [113], [13], [114], [19], [20], [115], [27], [116], [117], [28], [30], [31], [35], [36], [118], [38], [39], [119], [120], [40], [121], [122], [123], [124], [125]
	Increased risk of hyperglycemia					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[107], [108], [110]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[107], [108], [109], [110], [111]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[107], [108], [109], [110], [111]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[107], [108], [109], [110], [111]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[107], [108], [109], [110], [111]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[107], [108], [109], [110], [111]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[107], [108], [110]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[107], [108], [109], [110], [111]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[107], [108], [109], [110], [111]
	Increased risk of ventricular arrhythmias					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[52], [222]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[51], [52], [314]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[52], [126]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[129], [130], [131]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[52], [126]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[52], [126]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[52], [126]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[129], [130], [131]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[181], [182], [183]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[181], [182], [183]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[181], [182], [183]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[129], [130], [131]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[129], [130], [131]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[52], [126]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[129], [130], [131]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[52], [126]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[129], [130], [131]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[129], [130], [131]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[129], [130], [131]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[129], [130], [131]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[129], [130], [131]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[129], [130], [131]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[129], [130], [131]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[181], [182], [183]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[181], [182], [183]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[52], [126]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[129], [130], [131]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[129], [130], [131]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[52], [126]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[244], [245], [246]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[181], [182], [183]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[129], [130], [131]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[129], [130], [131]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[129], [130], [131]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[52], [126]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[52], [126]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[51], [52], [295]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[129], [130], [131]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[52], [126]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[129], [130], [131]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[52], [126]
D0017		Acetylsalicylic acid	C9H8O4	2244	Minor		Inter Info	[316], [317], [318]
D0489		Diflunisal	C13H8F2O3	3059	Minor		Inter Info	[316], [317], [318]
D0331		Choline salicylate	C12H19NO4	54686350	Minor		Inter Info	[316], [317], [318]
D1439		Salicylic acid (sodium)	C7H6O3	338	Minor		Inter Info	[316], [317], [318]
D1442		Salsalate	C14H10O5	5161	Minor		Inter Info	[316], [317], [318]
	Antagonize the effect of bronchodilators					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Major		Inter Info	[1], [2], [3]
D0544		Dyphylline	C10H14N4O4	3182	Major		Inter Info	[1], [2], [3]
D1201		Oxtriphylline	C12H21N5O3	656652	Major		Inter Info	[1], [2], [3]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[57]
D1570		Theophylline	C7H8N4O2	2153	Major		Inter Info	[1], [2], [3]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[187]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[204], [205], [206]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[261]
D1905		Tetrofosmin	C18H40O4P2	4274	Moderate		Inter Info	[262]

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216	Product Information. Methyldopa (methyldopa). Mylan Pharmaceuticals Inc, Morgantown, WV.
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219	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
220	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
221	Product Information. Alecensa (alectinib). Genentech, South San Francisco, CA.
222	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
223	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
224	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
225	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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228	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
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234	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
235	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
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256	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
257	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
258	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
259	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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262	Product Information. Myoview (tetrofosmin). GE Healthcare, Princeton, NJ.
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265	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
266	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
267	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
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282	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
283	Product Information. Blocadren (timolol). Merck & Co, Inc, West Point, PA.
284	Product Information. Brevibloc (esmolol). DuPont Pharmaceuticals, Wilmington, DE.
285	Product Information. Cartrol (carteolol). Abbott Pharmaceutical, Abbott Park, IL.
286	Product Information. Inderal (propranolol). Wyeth-Ayerst Laboratories, Philadelphia, PA.
287	Product Information. Levatol (penbutolol). Reed and Carnrick, Jersey City, NJ.
288	Product Information. Normodyne (labetalol). Schering Laboratories, Kenilworth, NJ.
289	Product Information. Rhythmol (propafenone). Knoll Pharmaceutical Company, Whippany, NJ.
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