Drug General Information (ID: DDIKFX4NEH)
Drug Name			Salsalate		Drug Info		Nebivolol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antihypertensive Agents
Structure

Mechanism of Salsalate-Nebivolol Interaction (Severity Level: Minor)
Antagonize the effect of antihypertensive agents Click to Show/Hide Mechanism Graph
Drug Name		Salsalate				Nebivolol
Mechanism		Decrease the antihypertensive effect of beta blocker by inhibition of prostaglandin synthesis				Beta blocker
Key Mechanism Factor 1
		Factor Name		Antihypertensive agents
		Factor Description		The hypotensive effect of antihypertensive agents may be reduced, leading to higher blood pressure, increased blood pressure fluctuations, and possible cardiovascular damage.
Mechanism Description		Antagonize the effect of Salsalate when combined with Nebivolol

References
1	Zanchetti A, Hansson L, Leonetti G, et al. "Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy." J Hypertens 20 (2002): 1015-1022. [PMID: 12011664]
2	Sziegoleit W, Rausch J, Polak G, et al "Influence of acetylsalicylic acid on acute circulatory effects of the beta-blocking agents pindolol and propranolol in humans." Int J Clin Pharmacol Ther Toxicol 20 (1982): 423-30
3	Keber I, Jerse M, Keber D, Stegnar M "The influence of combined treatment with propranolol and acetylsalicylic acid on platelet aggregation in coronary heart disease." Br J Clin Pharmacol 7 (1979): 287-91