Details of Drug

Drug General Information (ID: D1442)
Drug Name	Salsalate
Drug Type	Small molecule
Drug Synonymous	Diacesal; Diplosal; Disalcid; Disalicylsaeure; Disalyl; Nobacid; Salflex; Salical; Salina; Saloxium; Salsalato; Salsalatum;Salysal; Sasapirin; Sasapyrin; Sasapyrine; Sasapyrinum; Disalicylic acid; Sal Ester Sal; Salicylic Acid Salicylate; Salicyloylsalicylic acid; Salicylsalicylic acid; Disalcid (TN); O-Salicylcylsalicylsaeure; O-Salicyloylsalicylic Acid; O-Salicylsalicylic acid; Salflex (TN); Salicylic acid, bimolecular ester; Salicylic acid, salicylate; Salsalato [INN-Spanish]; Salsalatum [INN-Latin]; Salsitab (TN); Sasapyrine (JAN); Mono-Gesic (TN); Salsalate (USP/INN); Salsalate [USAN:INN:BAN]; Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester; 2-((2-Hydroxybenzoyl)oxy)benzoic acid; 2-(2-hydroxybenzoyl)oxybenzoic acid; 2-Carboxyphenyl salicylate; 2-Salicyloyloxybenzoic Acid; 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C14H10O5
InChI	1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
InChIKey	WVYADZUPLLSGPU-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C(=C1)C(=O)OC2=CC=CC=C2C(=O)O)O
External Link
	Pubchem ID	5161
	CAS Number	552-94-3
	CHEBI ID	9014
	TTD ID	D0Y0JH

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM005 Altered gastric pH BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM027 Decreased renal excretion due to nephrotoxicity BM028 Competitive inhibition of renal tubular secretion BM029 Altered urine pH BM032 Decreased renal excretion (Unspecific) BM038 Additive CNS depression effects BM039 Additive CNS stimulant effects BM050 Increased risk of bleeding BM054 Increased risk of GI mucosal injury/bleeding risk BM055 Increased risk of hepatotoxicity BM058 Increased risk of hyperkalemia BM064 Increased risk of hypoglycemia BM070 Increased risk of metabolic acidosis BM072 Increased risk of nephrotoxicity BM089 Antagonize the effect of antihypertensive agents BM099 Antagonize the effect of uricosuric agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Salsalate
Affected gastrointestinal absorption
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285]
	Altered gastric pH					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0603		Esomeprazole	C17H19N3O3S	9568614	Minor		Inter Info	[316], [317], [318]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Minor		Inter Info	[316], [317], [318]
D1179		Omeprazole	C17H19N3O3S	4594	Minor		Inter Info	[316], [317], [318]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Minor		Inter Info	[316], [317], [318]
D1373		Rabeprazole	C18H21N3O3S	5029	Minor		Inter Info	[316], [317], [318]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Minor		Inter Info	[316], [317], [318]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0207		Brinzolamide (ophthalmic)	C12H21N3O5S3	68844	Major		Inter Info	[5], [12], [13]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Major		Inter Info	[5], [12], [13]
D0521		Dorzolamide (ophthalmic)	C10H16N2O4S3	5284549	Major		Inter Info	[5], [12], [13]
D1018		Methazolamide	C5H8N4O3S2	4100	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[246]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[305], [306], [307], [308]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[319], [320], [321], [322], [323]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[288], [289], [290]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[223]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[237]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[254]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[255], [256], [257]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[3], [4], [300], [301], [302]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[304]
	Competitive inhibition of renal tubular secretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[29], [30], [31]
	Altered urine pH					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[215], [216], [217]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[215], [216], [217]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[215], [216], [217]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[215], [216], [217]
D0886		Lactic acid	C3H6O3	612	Moderate		Inter Info	[291], [211], [292]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[215], [216], [217]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[215], [216], [217]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[215], [216], [217]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[296], [297], [291], [211], [292]
D1478		Sodium acetate	C2H3NaO2	517045	Moderate		Inter Info	[296], [297], [291], [211], [292]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[296], [297], [291], [211], [292]
D1654		Tromethamine	C4H11NO3	6503	Moderate		Inter Info	[296], [297], [291], [211], [292]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[296], [297], [291], [211], [292]
	Decreased renal excretion (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[218], [219], [220]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[298]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
	Additive CNS stimulant effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
	Increased risk of bleeding					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1380		Ramucirumab	NA	NA	Major		Inter Info	[38]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[39], [40], [41], [42]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[147], [39], [148], [149], [150], [151], [152], [153]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[147], [39], [148], [149], [150], [151], [152], [153]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[171], [3], [4], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[209]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[165], [166], [170]
D0537		Drotrecogin alfa	NA	NA	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[232], [233], [234]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[39], [40], [41], [42]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[232], [233], [234]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[171], [3], [4], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[147], [39], [148], [149], [150], [151], [152], [153]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[171], [3], [4], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[171], [3], [4], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[299]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[4], [303]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[147], [39], [148], [149], [150], [151], [152], [153]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[147], [39], [148], [149], [150], [151], [152], [153]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[39], [40], [41], [42]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[232], [233], [234]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[147], [39], [148], [149], [150], [151], [152], [153]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0368		Clove	NA	NA	Minor		Inter Info	[324], [325], [326], [327]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[25]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[144], [145], [146]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[189], [190], [191], [192], [193]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[189], [190], [191], [192], [193]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[189], [190], [191], [192], [193]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[236]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[144], [145], [146]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[189], [190], [191], [192], [193]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[189], [190], [191], [192], [193]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[4], [239], [240], [144], [241], [145], [242], [146], [243], [244], [245]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[189], [190], [191], [192], [193]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[144], [145], [146]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[189], [190], [191], [192], [193]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[189], [190], [191], [192], [193]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[144], [145], [146]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[189], [190], [191], [192], [193]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[144], [145], [146]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[189], [190], [191], [192], [193]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[191], [192], [193]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[4], [239], [240], [144], [241], [145], [242], [146], [243], [244], [245]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[315]
	Increased risk of hepatotoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[26], [27], [28]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[26], [27], [28]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[4], [208]
	Increased risk of hyperkalemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[221], [222]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[224], [225], [186], [187], [226], [227], [228], [188], [229], [230], [231]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[50], [107], [124]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[50], [107], [124]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [247], [54], [55], [56], [57], [58], [59], [60], [61], [63], [64], [65], [67], [68], [69], [70], [72], [73], [74], [76], [78], [79], [80], [81], [82], [83], [84], [85], [86], [88], [91], [93], [94], [95], [98], [99], [101], [102], [103], [105], [248], [107], [249], [250], [112], [251], [252], [118], [120], [121], [122], [124], [126], [128], [130], [131], [135], [136], [137], [138], [253], [139], [140], [142], [143]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [247], [54], [55], [56], [57], [58], [59], [60], [61], [63], [64], [65], [67], [68], [69], [70], [72], [73], [74], [76], [78], [79], [80], [81], [82], [83], [84], [85], [86], [88], [91], [93], [94], [95], [98], [99], [101], [102], [103], [105], [248], [107], [249], [250], [112], [251], [252], [118], [120], [121], [122], [124], [126], [128], [130], [131], [135], [136], [137], [138], [253], [139], [140], [142], [143]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [247], [54], [55], [56], [57], [58], [59], [60], [61], [63], [64], [65], [67], [68], [69], [70], [72], [73], [74], [76], [78], [79], [80], [81], [82], [83], [84], [85], [86], [88], [91], [93], [94], [95], [98], [99], [101], [102], [103], [105], [248], [107], [249], [250], [112], [251], [252], [118], [120], [121], [122], [124], [126], [128], [130], [131], [135], [136], [137], [138], [253], [139], [140], [142], [143]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[50], [107], [124]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[50], [107], [124]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[50], [107], [124]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[50], [107], [124]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[50], [107], [124]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[50], [107], [124]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [247], [54], [55], [56], [57], [58], [59], [60], [61], [63], [64], [65], [67], [68], [69], [70], [72], [73], [74], [76], [78], [79], [80], [81], [82], [83], [84], [85], [86], [88], [91], [93], [94], [95], [98], [99], [101], [102], [103], [105], [248], [107], [249], [250], [112], [251], [252], [118], [120], [121], [122], [124], [126], [128], [130], [131], [135], [136], [137], [138], [253], [139], [140], [142], [143]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[50], [107], [124]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [247], [54], [55], [56], [57], [58], [59], [60], [61], [63], [64], [65], [67], [68], [69], [70], [72], [73], [74], [76], [78], [79], [80], [81], [82], [83], [84], [85], [86], [88], [91], [93], [94], [95], [98], [99], [101], [102], [103], [105], [248], [107], [249], [250], [112], [251], [252], [118], [120], [121], [122], [124], [126], [128], [130], [131], [135], [136], [137], [138], [253], [139], [140], [142], [143]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
	Increased risk of nephrotoxicity					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[14]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[22], [23], [24]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[32], [33]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[34], [35], [36]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[22], [23], [24]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[22], [23], [24]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[22], [23], [24]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[4], [37]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[17], [18], [19]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[15], [16], [17], [18], [19], [20], [21]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[34], [35], [36]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[34], [35], [36]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[34], [35], [36]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[155], [156], [158]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[182], [183], [184], [185]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[210], [211], [212], [213], [161], [214]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[183], [184], [185]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[182], [183], [184], [185]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[182], [183], [184], [185]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[154], [155], [156], [157], [158], [159]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[293], [294], [295]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[293], [294], [295]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[293], [294], [295]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[160], [161], [162]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[186], [187], [188]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[160], [161], [162]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[186], [187], [188]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[186], [187], [188]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[235], [25], [225]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[160], [161], [162]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[186], [187], [188]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[238]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[235], [25], [225]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[160], [161], [162]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[186], [187], [188]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[235], [25], [225]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[186], [187], [188]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[160], [161], [162]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[160], [161], [162]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[160], [161], [162]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[160], [161], [162]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[235], [25], [225]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[186], [187], [188]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[186], [187], [188]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[186], [187], [188]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[4], [286], [287]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[235], [25], [225]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[160], [161], [162]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[235], [25], [225]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[186], [187], [188]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[235], [25], [225]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[160], [161], [162]
D0010		Acebutolol	C18H28N2O4	1978	Minor		Inter Info	[309], [310], [311]
D0117		Atenolol	C14H22N2O3	2249	Minor		Inter Info	[309], [310], [311]
D0173		Betaxolol	C18H29NO3	2369	Minor		Inter Info	[309], [310], [311]
D0188		Bisoprolol	C18H31NO4	2405	Minor		Inter Info	[309], [310], [311]
D0265		Carteolol	C16H24N2O3	2583	Minor		Inter Info	[309], [310], [311]
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[309], [310], [311]
D0602		Esmolol	C16H25NO4	59768	Minor		Inter Info	[309], [310], [311]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[309], [310], [311]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[309], [310], [311]
D1098		Nadolol	C17H27NO4	39147	Minor		Inter Info	[309], [310], [311]
D1244		Penbutolol	C18H29NO2	37464	Minor		Inter Info	[309], [310], [311]
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[309], [310], [311]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[309], [310], [311]
D1114		Nebivolol	C22H25F2NO4	71301	Minor		Inter Info	[309], [310], [311]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[309], [310], [311]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[309], [310], [311]
	Antagonize the effect of uricosuric agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[4], [258], [259], [260]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Minor		Inter Info	[312], [313], [314]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Minor		Inter Info	[312], [313], [314]
D0704		Furosemide	C12H11ClN2O5S	3440	Minor		Inter Info	[312], [313], [314]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[328], [329], [330]
D1611		Torasemide	C16H20N4O3S	41781	Minor		Inter Info	[312], [313], [314]

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294	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
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316	Miner PB Jr, Fort JG, Zhang Y. Intragastric acidity and omeprazole exposure during dosing with either PA32540 (enteric-coated aspirin 325?mg + immediate-release omeprazole 40?mg) or enteric-coated aspirin 325?mg + enteric-coated omeprazole 40?mg - a randomised, phase 1, crossover study.?Aliment Pharmacol Ther. 2013;38(1):62-71. [PMID: 23692061]
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