Drug General Information (ID: DDI3E7KSF0)
Drug Name			Levofloxacin		Drug Info		Salsalate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antiinflammatory Agents
Structure

Mechanism of Levofloxacin-Salsalate Interaction (Severity Level: Moderate)
Additive CNS stimulant effects Click to Show/Hide Mechanism Graph
Drug Name		Levofloxacin				Salsalate
Mechanism		CNS stimulant effects				CNS stimulant effects
Key Mechanism Factor 1
		Factor Name		CNS stimulant effects
		Factor Description		CNS stimulants are drugs that stimulate the brain and can speed up mental and physical processes. Excessive CNS stimulation may lead to decreased appetite, increased heart rate, increased blood pressure, increased body temperature, convulsions, and seizures.
Mechanism Description		Additive CNS stimulant effects by the combination of Levofloxacin and Salsalate

Recommended Action
Management		Clinical monitoring for signs of CNS stimulation such as tremors, involuntary muscle movements, hallucinations, or seizures is recommended if fluoroquinolone antibiotics are prescribed in combination with NSAIDs.

References
1	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
2	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
3	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
4	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
5	Product Information. Floxin (ofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
6	Product Information. Penetrex (enoxacin). Rhone-Poulenc Rorer, Collegeville, PA.
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14	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.