Drug General Information (ID: DDIZ3KNM5J)
Drug Name			Ethanol		Drug Info		Salsalate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antiinflammatory Agents
Structure

Mechanism of Ethanol-Salsalate Interaction (Severity Level: Moderate)
Increased risk of GI mucosal injury/bleeding risk Click to Show/Hide Mechanism Graph
Drug Name		Ethanol				Salsalate
Mechanism		GI mucosal injury/bleeding risk				GI mucosal injury/bleeding risk
Key Mechanism Factor 1
		Factor Name		Gastrointestinal toxicity
		Factor Description		The risk and severity of gastrointestinal toxicity, including inflammation, bleeding, ulceration, and perforation, increases when drugs with gastrointestinal mucosal irritant effects are combined.
Mechanism Description		Increased risk of GI mucosal injury/bleeding risk by the combination of Ethanol and Salsalate

Recommended Action
Management		Patients should be counseled on this potential interaction and advised to refrain from alcohol consumption while taking aspirin or NSAIDs.

References
1	Product Information. Motrin (ibuprofen). Pharmacia and Upjohn, Kalamazoo, MI.