Drug General Information (ID: DDIFV079RI)
  Drug Name Insulin glulisine Drug Info Salsalate Drug Info
  Drug Type Hormones Small molecule
  Therapeutic Class Antidiabetic Agents Antiinflammatory Agents
  Structure

 Mechanism of Insulin glulisine-Salsalate Interaction (Severity Level: Moderate)
     Increased risk of hypoglycemia Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Insulin glulisine Salsalate
      Mechanism Hypoglycemic effects Hypoglycemic effects
      Key Mechanism Factor 1
Factor Name Hypoglycemia
Factor Description Hypoglycemia is a condition in which your blood sugar (glucose) level is below the standard range. It causes irregular or rapid heartbeat, pale skin, numbness of the lips, tongue or cheeks, and sweating.
      Mechanism Description
  • Increased risk of hypoglycemia by the combination of Insulin glulisine and Salsalate 

Recommended Action
      Management Close monitoring for the development of hypoglycemia is recommended if these drugs are coadministered with insulin, particularly in patients with advanced age and/or renal impairment. The insulin dosage may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations).

References
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52 Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
53 Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
54 Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
55 Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
56 Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
57 Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
58 Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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