Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI17PQGA5)
  Drug Name Mexiletine Drug Info Sodium phosphate, monobasic Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Laxatives/Minerals And Electrolytes

 Mechanism of Mexiletine-Sodium phosphate, monobasic Interaction (Severity Level: Minor)
     Altered urine pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Mexiletine Sodium phosphate, monobasic
      Mechanism Urine pH sensitive Urine acidifier
      Key Mechanism Factor 1
Factor Name Urine pH
Factor Description The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
      Mechanism Description
  • Altered elimination of Mexiletine caused by Sodium phosphate, monobasic mediated altered urine pH

References
1 Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4. [PMID: 6626420]