Details of Drug-Drug Interaction
| Drug General Information (ID: DDI3GALHDU) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Mexiletine | Drug Info | Sodium citrate | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiarrhythmic Agents | Minerals And Electrolytes | |||||||
| Structure | |||||||||
| Mechanism of Mexiletine-Sodium citrate Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered urine pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Mexiletine | Sodium citrate | |||||||
| Mechanism | Urine pH sensitive | Urine alkalinizer | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Urine pH | ||||||||
| Factor Description | The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | It is recommended that such drugs be avoided during mexiletine therapy. | ||||||||