Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIN2DHR16)
  Drug Name Mexiletine Drug Info Ammonium chloride Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiarrhythmic Agents Minerals And Electrolytes
  Structure

 Mechanism of Mexiletine-Ammonium chloride Interaction (Severity Level: Minor)
     Altered urine pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Mexiletine Ammonium chloride
      Mechanism Urine pH sensitive Urine acidifier
      Key Mechanism Factor 1
Factor Name Urine pH
Factor Description The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion.
      Mechanism Description
  • Altered elimination of Mexiletine caused by Ammonium chloride mediated altered urine pH

References
1 Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4. [PMID: 6626420]