Details of Drug

Details of Drug

 Drug General Information (ID: D0070)
  Drug Name
Ammonium chloride
  Drug Type Small molecule
  Drug Synonymous
AMMONIUM CHLORIDE; 12125-02-9; Salmiac; Sal ammoniac; Ammonium muriate; Ammoniumchlorid; Ammoneric; Darammon; Amchlor; Ammonium chloride ((NH4)Cl); Chlorammonic; Salammonite; Ammoniumklorid; Elektrolyt; Chloramon; Ammonchlor; Sal ammonia; Ammon Chlor; Ammonii Chloridum; Ammonium Chloratum; Cloruro de Amonio; Muriate of Ammonia; Gen-Diur (Spain); Chlorammonic [France]; Ammonium chloride fume; Chlorid amonny [Czech]; ammoniumchloride; Ammoniumchlorid [German]; azanium chloride; Chlorid ammonia [Czech]; Ammonium Chloride Tablets; Ammonium C
    Click to Show/Hide
  Disease Class GC08: Urinary tract infection
  Therapeutic Class Minerals And Electrolytes
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula ClH4N
  InChI 1S/ClH.H3N/h1H;1H3
  InChIKey NLXLAEXVIDQMFP-UHFFFAOYSA-N
  Canonical SMILES [NH4+].[Cl-]
  External Link
Pubchem ID 25517
CAS Number 12125-02-9
TTD ID D06WEK

Drug-Drug Interaction Network
  Sunburst Graph
AM005  Affected excretion pathways
BM029  Altered urine pH
  Relation Graph
 Full list of drugs interacting with Ammonium chloride
      Affected excretion pathways
   Altered urine pH Drug Num:  21
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0074
 
Amphetamine
 
C9H13N
 
3007 
Moderate    Inter Info   
[1], [2], [3]
D0165
 
Benzphetamine
 
C17H21N
 
5311017 
Moderate    Inter Info   
[1], [2], [3]
D0465
 
Dextroamphetamine
 
C9H13N
 
5826 
Moderate    Inter Info   
[1], [2], [3]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[1], [2], [3]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Moderate    Inter Info   
[1], [2], [3]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Minor    Inter Info   
[4]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Minor    Inter Info   
[4]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Minor    Inter Info   
[4]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Minor    Inter Info   
[4]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Minor    Inter Info   
[4]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Minor    Inter Info   
[4]
D0579
 
Ephedrine
 
C10H15NO
 
9294 
Minor    Inter Info   
[5], [6], [7]
D0580
 
Ephedrine (nasal)
 
C10H15NO
 
9294 
Minor    Inter Info   
[5], [6], [7]
D0664
 
Flecainide
 
C17H20F6N2O3
 
3356 
Minor    Inter Info   
[8]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Minor    Inter Info   
[4]
D1017
 
Methadone
 
C21H27NO
 
4095 
Minor    Inter Info   
[9], [10], [11]
D1054
 
Mexiletine
 
C11H17NO
 
4178 
Minor    Inter Info   
[12]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Minor    Inter Info   
[4]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Minor    Inter Info   
[4]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Minor    Inter Info   
[5], [6], [7]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Minor    Inter Info   
[4]
References
1 Beckett AH, Rowland M, Turner P "Influence of urinary pH on excretion of amphetamine." Lancet 1 (1965): 303. [PMID: 14247879]
2 Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
3 Gary NE, Saidi P "Methamphetamine intoxication. A speedy new treatment." Am J Med 64 (1978): 537-40
4 Gram LF, Kofod B, Christiansen J, Rafaelsen OJ "Imipramine metabolism: pH-dependent distribution and urinary excretion." Clin Pharmacol Ther 12 (1971): 239-44. [PMID: 5554940]
5 Brater DC, Kaojarern S, Benet LZ, et al "Renal excretion of pseudoephedrine." Clin Pharmacol Ther 28 (1980): 690-4. [PMID: 7438686]
6 Kuntzman RG, Tsai I, Brand L, Mark LC "The influence of urinary pH on the plasma half-life of pseudoephedrine in man and dog and a sensitive assay for its determination in human plasma." Clin Pharmacol Ther 12 (1971): 62-7. [PMID: 5541135]
7 Wilkinson GR, Beckett AH "Absorption metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output." J Pharmacol Exp Ther 162 (1968): 139-47. [PMID: 5656593]
8 Hertrampf R, Gundert-Remy U, Beckmann J, et al "Elimination of flecainide as a function of urinary flow rate and pH." Eur J Clin Pharmacol 41 (1991): 61-3. [PMID: 1782979]
9 Benmebarek M, Devaud C, Gex-Fabry M, et al. "Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone." Clin Pharmacol Ther 76 (2004): 55-63
10 Nilsson M-I, Widerlov E, Meresaar U, Anggard E "Effect of urinary pH on the disposition of methadone in man." Eur J Clin Pharmacol 22 (1982): 337-42
11 Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32
12 Mitchell BG, Clements JA, Pottage A, Prescott LF "Mexiletine disposition: individual variation in response to urine acidification and alkalinisation." Br J Clin Pharmacol 16 (1983): 281-4. [PMID: 6626420]