Details of Drug-Drug Interaction
| Drug General Information (ID: DDIHPMQOI5) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Doxepin | Drug Info | Ammonium chloride | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antidepressants | Minerals And Electrolytes | |||||||
| Structure | |||||||||
| Mechanism of Doxepin-Ammonium chloride Interaction (Severity Level: Minor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Altered urine pH Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Doxepin | Ammonium chloride | |||||||
| Mechanism | Urine pH sensitive | Urine acidifier | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Urine pH | ||||||||
| Factor Description | The normal range of urine pH is between 4.5 and 8, depending mainly on the hydrogen ion concentration. Changes in urine pH may significantly affect drug reabsorption and excretion. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Gram LF, Kofod B, Christiansen J, Rafaelsen OJ "Imipramine metabolism: pH-dependent distribution and urinary excretion." Clin Pharmacol Ther 12 (1971): 239-44. [PMID: 5554940] | ||||||||||||||||||