Drug General Information (ID: DDIY2RF81H)
Drug Name			Morphine		Drug Info		Mexiletine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antiarrhythmic Agents
Structure

Mechanism of Morphine-Mexiletine Interaction (Severity Level: Moderate)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Morphine				Mexiletine
Mechanism		Delayed gastric emptying				Absorption affected by delayed gastric emptying
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Mexiletine due to GI dynamics variation caused by Morphine

Recommended Action
Management		Monitoring for altered efficacy is advisable.

References
1	Canadian Pharmacists Association.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Pottage A, Campbell RW, Achuff SC, Murray A, Julian DG, Prescott LF "The absorption of oral mexiletine in coronary care patients." Eur J Clin Pharmacol 13 (1978): 393-9.
4	Smyllie HC, Doar JW, Head CD, Leggett RJ "A trial of intravenous and oral mexiletine in acute myocardial infarction." Eur J Clin Pharmacol 26 (1984): 537-42. [PMID: 6381065]