Details of Drug

Drug General Information (ID: D0613)
Drug Name	Etacrynic acid
Drug Type	Small molecule
Drug Synonymous	Crinuryl; Edecril; Edecrina; Endecril; Ethacrynate; Hidromedin; Hydromedin; Mingit; Otacril; Reomax; Taladren; Uregit; Acide etacrynique; Acido etacrinico; Acidum etacrynicum; Etacrinic acid; Etacrynic Acid; Etakrinic acid; Ethacrinic acid; Ethacryinic Acid; Kyselina ethakrynova; Kyselina ethakrynova [Czech]; Methylenebutyryl phenoxyacetic acid; Methylenebutyrylphenoxyacetic acid; E0526; MK 595; Acide etacrynique [INN-French]; Acido etacrinico [INN-Spanish]; Acidum etacrynicum [INN-Latin]; Edecrin (TN); Ethacrinique (acide); Ethacrynic Acid, Sodium Salt; Ethacrynic acid (USP); Ethacrynic acid [USAN:BAN]; MK-595; Etacrynic acid (JP15/INN); [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid; [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova [Czech]; [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid; (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-methylenebutyryl)phenoxy)acetic acid; (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid; (4-(2-Methylenebutyryl)-2,3-dichlorophenoxy)acetic acid; 2,3-Dichloro-4(2-methylene-butyryl)phenoxy] acetic acid; 2,3-Dichloro-4-(2-methylenebutyl)phenoxyacetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxy acetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid; 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid Click to Show/Hide
Disease Class	BA00: Essential hypertension
Therapeutic Class	Diuretics
Structure
Structure	3D Structure		2D Structure
Formula	C13H12Cl2O4
InChI	1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChIKey	AVOLMBLBETYQHX-UHFFFAOYSA-N
Canonical SMILES	CCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
External Link
	Pubchem ID	3278
	CAS Number	58-54-8
	CHEBI ID	4876
	TTD ID	D06TNL
	INTEDE ID	DR0653
	VARIDT ID	DR00548

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM013 Competitive binding of plasma proteins BM027 Decreased renal excretion due to nephrotoxicity BM028 Competitive inhibition of renal tubular secretion BM031 Increased renal excretion (Unspecific) BM032 Decreased renal excretion (Unspecific) BM042 Additive hypotensive effects BM053 Increased risk of fluid/electrolyte loss BM057 Increased risk of hyperglycemia BM062 Increased risk of hypertriglyceridemia BM063 Increased risk of hypocalcemia BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM067 Increased risk of hyponatremia BM070 Increased risk of metabolic acidosis BM072 Increased risk of nephrotoxicity BM073 Increased risk of ototoxicity BM075 Increased risk of photosensitivity reactions BM081 Increased risk of ventricular arrhythmias BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Etacrynic acid
Affected gastrointestinal absorption
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[84], [85]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[84], [85]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[11], [137], [138]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[131]
	Competitive inhibition of renal tubular secretion					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[139]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[139]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[139]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[139]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[139]
	Increased renal excretion (Unspecific)					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0272		Cefadroxil	C16H17N3O5S	47965	Moderate		Inter Info	[70], [71], [72]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[70], [71], [72]
D0275		Cefapirin	C17H17N3O6S2	30699	Moderate		Inter Info	[70], [71], [72]
D0278		Cefditoren	C19H18N6O5S3	9870843	Moderate		Inter Info	[70], [71], [72]
D0279		Cefepime	C19H24N6O5S2	5479537	Moderate		Inter Info	[70], [71], [72]
D0283		Cefonicid	C18H18N6O8S3	43594	Moderate		Inter Info	[70], [71], [72]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[70], [71], [72]
D0286		Cefotetan	C17H17N7O8S4	53025	Moderate		Inter Info	[70], [71], [72]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[70], [71], [72]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[70], [71], [72]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[70], [71], [72]
D0290		Cefradine	C16H19N3O4S	38103	Moderate		Inter Info	[70], [71], [72]
D0291		Ceftaroline fosamil	C22H21N8O8PS4	9852981	Moderate		Inter Info	[70], [71], [72]
D0293		Ceftibuten	C15H14N4O6S2	5282242	Moderate		Inter Info	[70], [71], [72]
D0294		Ceftizoxime	C13H13N5O5S2	6533629	Moderate		Inter Info	[70], [71], [72]
D0295		Ceftolozane	C23H30N12O8S2	53234134	Moderate		Inter Info	[70], [71], [72]
D0296		Ceftriaxone	C18H18N8O7S3	5479530	Moderate		Inter Info	[70], [71], [72]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[70], [71], [72]
D0949		Loracarbef	C16H16ClN3O4	5284585	Moderate		Inter Info	[70], [71], [72]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[28], [29], [30]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 129
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[34]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[41]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[43], [44], [45]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[43], [44], [45]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[43], [44], [45]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[47], [48], [49]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[43], [44], [45]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[56], [57], [58]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[62], [63], [64]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[62], [63], [64]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[43], [44], [45]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[43], [44], [45]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[43], [44], [45]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[43], [44], [45]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[43], [44], [45]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[43], [44], [45]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[75], [76], [77]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[43], [44], [45]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[43], [44], [45]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[43], [44], [45]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[75], [76], [77]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[11], [86], [87]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[43], [44], [45]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[43], [44], [45]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[56], [57], [58]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[75], [76], [77]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[47], [27], [99]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[75], [76], [77]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[62], [63], [64]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[75], [76], [77]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[75], [76], [77]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[103], [104], [105]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[43], [44], [45]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[75], [76], [77]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[43], [44], [45]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[23], [109], [110]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[56], [57], [58]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[75], [76], [77]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[43], [44], [45]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[43], [44], [45]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[43], [44], [45]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[43], [44], [45]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[43], [44], [45]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[23], [109], [110]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[43], [44], [45]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[43], [44], [45]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[43], [44], [45]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[43], [44], [45]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[43], [44], [45]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[43], [44], [45]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[43], [44], [45]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[23], [109], [110]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[23], [113], [114]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[43], [44], [45]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[23], [113], [114]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[117], [118], [119]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[47], [48], [120]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[75], [76], [77]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[75], [76], [77]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[43], [44], [45]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[124]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[75], [76], [77]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[75], [76], [77]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[75], [76], [77]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[125], [94], [126]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[43], [44], [45]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[43], [44], [45]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[117], [118], [119]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[43], [44], [45]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[117], [118], [119]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[75], [76], [77]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[43], [44], [45]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[75], [76], [77]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[117], [118], [119]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[43], [44], [45]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[130]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[117], [118], [119]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[117], [118], [119]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[23], [113], [114]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[43], [44], [45]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[43], [44], [45]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[75], [76], [77]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[43], [44], [45]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[43], [44], [45]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[43], [44], [45]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[27], [132]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[75], [76], [77]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[43], [44], [45]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[56], [57], [58]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[43], [44], [45]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[75], [76], [77]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[43], [44], [45]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[43], [44], [45]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[56], [57], [58]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[43], [44], [45]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[75], [76], [77]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[43], [44], [45]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[43], [44], [45]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[75], [76], [77]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[43], [44], [45]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[43], [44], [45]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[43], [44], [45]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[43], [44], [45]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[43], [44], [45]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[75], [76], [77]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[43], [44], [45]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[135]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[56], [57], [58]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[75], [76], [77]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[117], [118], [119]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[75], [76], [77]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[75], [76], [77]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[75], [76], [77]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[43], [44], [45]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[56], [57], [58]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[56], [57], [58]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[103], [104], [105]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[43], [44], [45]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[56], [57], [58]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[117], [118], [119]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[43], [44], [45]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[23], [113], [114]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[43], [44], [45]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[75], [76], [77]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[43], [44], [45]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[103], [104], [105]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[43], [44], [45]
D0711		Garlic	NA	NA	Minor		Inter Info	[146], [147]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[148], [149]
	Increased risk of fluid/electrolyte loss					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[59], [60], [61]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[61], [59], [60]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[59], [60], [61]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[59], [60], [61]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[59], [60], [61]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[59], [60], [61]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[59], [60], [61]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[59], [60], [61]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[59], [60], [61]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[59], [60], [61]
	Increased risk of hyperglycemia					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[50], [51], [52]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[50], [51], [52]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[50], [51], [52]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[50], [51], [52]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[50], [51], [52]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[50], [51], [52]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[50], [51], [52]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[50], [51], [52]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[50], [51], [52]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[50], [51], [52]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[50], [51], [52]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[50], [51], [52]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[50], [51], [52]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[50], [51], [52]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[50], [51], [52]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[50], [51], [52]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[50], [51], [52]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[50], [51], [52]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[50], [51], [52]
	Increased risk of hypocalcemia					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[23], [24]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[24], [42]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[24], [42]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[24], [42]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[24], [42]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[24], [42]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[24], [42]
	Increased risk of hypokalemia					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[23]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[23]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[23]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[23]
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[53], [54], [55]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[53], [54], [55]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[91], [92], [93]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[100], [101], [102]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[53], [54], [55]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[53], [54], [55]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[53], [54], [55]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[91], [92], [93]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[100], [101], [102]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[100], [101], [102]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[100], [101], [102]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[121], [122], [123]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[53], [54], [55]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[100], [101], [102]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[100], [101], [102]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[100], [101], [102]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[53], [54], [55]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[100], [101], [102]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[53], [54], [55]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[53], [54], [55]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[100], [101], [102]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[100], [101], [102]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[53], [54], [55]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[53], [54], [55]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[100], [101], [102]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[53], [54], [55]
	Increased risk of hypomagnesemia					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[96], [97], [98]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[96], [97], [98]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[96], [97], [98]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[96], [97], [98]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[96], [97], [98]
	Increased risk of hyponatremia					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Major		Inter Info	[9], [10], [11]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[67], [68], [69]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[81], [82], [83]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[81], [82], [83]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[115]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[81], [82], [83]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[81], [82], [83]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[81], [82], [83]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[81], [82], [83]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[81], [82], [83]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[81], [82], [83]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[81], [82], [83]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[81], [82], [83]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[81], [82], [83]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[81], [82], [83]
	Increased risk of metabolic acidosis					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[23], [95], [133]
	Increased risk of nephrotoxicity					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[11], [65], [66]
D0271		Cefaclor	C15H14ClN3O4S	51039	Moderate		Inter Info	[70], [71], [72]
D0273		Cefalotin	C16H16N2O6S2	6024	Moderate		Inter Info	[70], [71], [72]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[70], [71], [72]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[70], [71], [72]
D0282		Cefmetazole	C15H17N7O5S3	42008	Moderate		Inter Info	[70], [71], [72]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[70], [71], [72]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[70], [71], [72]
D0301		Cephalexin	C16H17N3O4S	27447	Moderate		Inter Info	[70], [71], [72]
D0472		Diatrizoate	C11H9I3N2O4	2140	Moderate		Inter Info	[88], [89], [90]
D0831		Iodipamide	C20H14I6N2O6	3739	Moderate		Inter Info	[88], [89], [90]
D0832		Iodixanol	C35H44I6N6O15	3724	Moderate		Inter Info	[88], [89], [90]
D0833		Iohexol	C19H26I3N3O9	3730	Moderate		Inter Info	[88], [89], [90]
D0834		Iopamidol	C17H22I3N3O8	65492	Moderate		Inter Info	[88], [89], [90]
D0836		Iopromide	C18H24I3N3O8	3736	Moderate		Inter Info	[88], [89], [90]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Moderate		Inter Info	[88], [89], [90]
D0838		Ioversol	C18H24I3N3O9	3741	Moderate		Inter Info	[88], [89], [90]
D0839		Ioxilan	C18H24I3N3O8	3743	Moderate		Inter Info	[88], [89], [90]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[11], [65], [66]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Minor		Inter Info	[140], [141], [142]
D0530		Doxycycline	C22H24N2O8	54671203	Minor		Inter Info	[140], [141], [142]
D1070		Minocycline	C23H27N3O7	54675783	Minor		Inter Info	[140], [141], [142]
D1209		Oxytetracycline	C22H24N2O9	54675779	Minor		Inter Info	[140], [141], [142]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[140], [141], [142]
	Increased risk of ototoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0704		Furosemide	C12H11ClN2O5S	3440	Major		Inter Info	[32], [33]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[78], [79], [80]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[111], [78], [112]
	Increased risk of photosensitivity reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[4], [5]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[11], [23], [46]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[11], [23], [46]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[11], [95], [134]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[23], [95], [136]
	Increased risk of ventricular arrhythmias					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[6], [7], [8]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[12]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[13]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[14], [15], [16]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[17], [18], [19]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[20], [21]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[22]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[25], [26], [27]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[6], [31]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[35], [36], [37]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[23], [94], [95]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[11], [23]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[11], [23]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[11], [23]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[106], [107], [108]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[106], [107], [108]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[106], [107], [108]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[106], [107], [108]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[106], [107], [108]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[106], [107], [108]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[106], [107], [108]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[106], [107], [108]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[127], [128], [129]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[127], [128], [129]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[106], [107], [108]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[106], [107], [108]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[38], [39], [40]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[38], [39], [40]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[38], [39], [40]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[38], [39], [40]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[38], [39], [40]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[38], [39], [40]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[38], [39], [40]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[38], [39], [40]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[38], [39], [40]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[38], [39], [40]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[38], [39], [40]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[38], [39], [40]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[38], [39], [40]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[38], [39], [40]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[38], [39], [40]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[38], [39], [40]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[38], [39], [40]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[38], [39], [40]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[38], [39], [40]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[38], [39], [40]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[38], [39], [40]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[38], [39], [40]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[38], [39], [40]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[38], [39], [40]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[38], [39], [40]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[38], [39], [40]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[38], [39], [40]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[38], [39], [40]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[38], [39], [40]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[38], [39], [40]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[38], [39], [40]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[38], [39], [40]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[38], [39], [40]
	Antagonize the effect of antihypertensive agents					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[73], [74], [28]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[73], [74], [28]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[73], [74], [28]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[73], [74], [28]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[38], [39], [40]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[73], [74], [28]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[73], [74], [28]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[73], [74], [28]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[73], [74], [28]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[38], [39], [40]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[73], [74], [28]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[73], [74], [28]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[73], [74], [28]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[73], [74], [28]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[73], [74], [28]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[73], [74], [28]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[73], [74], [28]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[73], [74], [28]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[73], [74], [28]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[73], [74], [28]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[73], [74], [28]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[73], [74], [28]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[116]
D0017		Acetylsalicylic acid	C9H8O4	2244	Minor		Inter Info	[143], [144], [145]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Minor		Inter Info	[143], [144], [145]
D0331		Choline salicylate	C12H19NO4	54686350	Minor		Inter Info	[143], [144], [145]
D1272		Phenyl salicylate	C13H10O3	8361	Minor		Inter Info	[143], [144], [145]
D1439		Salicylic acid (sodium)	C7H6O3	338	Minor		Inter Info	[143], [144], [145]
D1442		Salsalate	C14H10O5	5161	Minor		Inter Info	[143], [144], [145]

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