Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIN56HT4Q)
  Drug Name Etacrynic acid Drug Info Lomefloxacin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Diuretics Antibiotics
  Structure

 Mechanism of Etacrynic acid-Lomefloxacin Interaction (Severity Level: Minor)
     Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Etacrynic acid Lomefloxacin
      Mechanism Competitive inhibition of renal tubular secretion of quinolone Quinolone
      Key Mechanism Factor 1
Factor Name Renal tubular secretion
Factor Description Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
      Mechanism Description
  • Decreased elimination of Lomefloxacin caused by Etacrynic acid mediated competitive inhibition of renal tubular secretion

References
1 Sudoh T, Fujimura A, Shiga T, Sasaki M, Harada K, Tateishi T, Ohashi K, Ebihara A "Renal clearance of lomefloxacin is decreased by furosemide." Eur J Clin Pharmacol 46 (1994): 267-9. [PMID: 8070509]