Drug General Information (ID: DDIVDO15XB)
Drug Name			Etacrynic acid		Drug Info		Cefapirin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antibiotics
Structure

Mechanism of Etacrynic acid-Cefapirin Interaction (Severity Level: Moderate)
Increased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Etacrynic acid				Cefapirin
Mechanism		Increase the risk of cephalosporins-induced nephrotoxicity				Cephalosporins
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased renal excretion of Cefapirin caused by Etacrynic acid

Recommended Action
Management		Although data are primarily limited to cephaloridine, which is no longer commercially marketed, caution may be advisable in patients receiving a loop diuretic in combination with other cephalosporins. Renal function should be monitored, particularly when high dosages are used or when these medications are administered in the elderly or patients with preexisting renal impairment.

References
1	Chrysos G, Gargalianos P, Lelekis M, Stefanou J, Kosmidis J "Pharmacokinetic interactions of ceftazidime and frusemide." J Chemother 7 Suppl (1995): 107-10. [PMID: 8904125]
2	Dodds MG, Foord RD "Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine." Br J Pharmacol 40 (1970): 227-36. [PMID: 5492895]
3	Norrby R, Stenqvist K, Elgefors B "Interaction between cephaloridine and furosemide in man." Scand J Infect Dis 8 (1976): 209-12. [PMID: 968459]