Drug General Information (ID: DDISCXPZ09)
Drug Name			Etacrynic acid		Drug Info		Ginseng		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Diuretics				Herbal Products
Structure

Mechanism of Etacrynic acid-Ginseng Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Etacrynic acid				Ginseng
Mechanism		Diuretic				Induce diuretic resistance
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Etacrynic acid when combined with Ginseng

Recommended Action
Management		Until further data are available, patients treated with furosemide or other loop diuretics should preferably avoid the use of ginseng supplements. The possibility of diuretic resistance should be considered and appropriately monitored if concomitant use is necessary.

References
1	Becker BN, Greene J, Evanson J, Chidsey G, Stone WJ "Ginseng-induced diuretic resistance." JAMA 276 (1996): 606-7