Details of Drug

Drug General Information (ID: D0723)
Drug Name	Ginseng
Drug Type	Natural product
Drug Synonymous	Ginseng; Prosapogenin; Panax ginseng extract; 50647-08-0; bis[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] 2,3-dihydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylate; NSC124670; CHEMBL1970059; CHEBI:189965; NSC-124670; XP173068; 2,3-Dihydroxy-6b-hydroxymethyl-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,6b,7,8,9,10,11,12,12a,14,14a,14b-octadecahydro-1H-picene-4,8a-dicarboxylic acid bis-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl) ester; bis[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl] 2,3-dihydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylate Click to Show/Hide
Therapeutic Class	Herbal Products
Structure
Structure	3D Structure		2D Structure
Formula	C42H66O17
InChI	InChI=1S/C42H66O17/c1-37(2)10-11-41(36(55)59-34-31(52)29(50)27(48)23(17-44)57-34)12-13-42(18-45)19(20(41)14-37)6-7-24-38(3)15-21(46)32(53)40(5,25(38)8-9-39(24,42)4)35(54)58-33-30(51)28(49)26(47)22(16-43)56-33/h6,20-34,43-53H,7-18H2,1-5H3
InChIKey	YDQIRODFTJGGMP-UHFFFAOYSA-N
Canonical SMILES	CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C(=O)OC6C(C(C(C(O6)CO)O)O)O)O)O)C)C)C2C1)CO)C(=O)OC7C(C(C(C(O7)CO)O)O)O)C
External Link
External Link	Pubchem ID	420552

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM050 Increased risk of bleeding BM064 Increased risk of hypoglycemia BM085 Antagonize the effect of antithrombotic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ginseng
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[2], [17], [5]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[2], [17], [5]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[2], [17], [5]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[2], [17], [5]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[2], [17], [5]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[2], [17], [5]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[2], [17], [5]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[2], [17], [5]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[2], [17], [5]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[2], [17], [5]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[2], [17], [5]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[2], [17], [5]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[2], [17], [5]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[2], [17], [5]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10]
	Increased risk of hypoglycemia					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[11], [12], [13]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[14], [15], [16]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[14], [15], [16]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[11], [12], [13]
D0660		Finasteride	C23H36N2O2	57363	Moderate		Inter Info	[11], [12], [13]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[11], [12], [13]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[11], [12], [13]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[11], [12], [13]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[11], [12], [13]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[11], [12], [13]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [14], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [16], [85], [11], [86], [87], [88], [89], [90], [91]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[11], [12], [13]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[11], [12], [13]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[11], [12], [13]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[11], [12], [13]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [14], [33], [34], [35], [36], [37], [92], [38], [39], [40], [93], [41], [42], [43], [44], [15], [45], [46], [47], [94], [48], [95], [49], [50], [51], [52], [53], [54], [55], [56], [57], [96], [58], [97], [98], [59], [99], [60], [61], [62], [100], [101], [63], [64], [102], [65], [66], [67], [103], [68], [104], [70], [105], [106], [107], [108], [73], [109], [110], [111], [112], [113], [76], [114], [77], [78], [79], [115], [80], [116], [81], [117], [82], [118], [83], [84], [119], [120], [121], [16], [85], [11], [86], [88], [89], [122], [90], [91]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [14], [33], [34], [35], [36], [37], [92], [38], [39], [40], [93], [41], [42], [43], [44], [15], [45], [46], [47], [94], [48], [95], [49], [50], [51], [52], [53], [54], [55], [56], [57], [96], [58], [97], [98], [59], [99], [60], [61], [62], [100], [101], [63], [64], [102], [65], [66], [67], [103], [68], [104], [70], [105], [106], [107], [108], [73], [109], [110], [111], [112], [113], [76], [114], [77], [78], [79], [115], [80], [116], [81], [117], [82], [118], [83], [84], [119], [120], [121], [16], [85], [11], [86], [88], [89], [122], [90], [91]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [14], [33], [34], [35], [36], [37], [92], [38], [39], [40], [93], [41], [42], [43], [44], [15], [45], [46], [47], [94], [48], [95], [49], [50], [51], [52], [53], [54], [55], [56], [57], [96], [58], [97], [98], [59], [99], [60], [61], [62], [100], [101], [63], [64], [102], [65], [66], [67], [103], [68], [104], [70], [105], [106], [107], [108], [73], [109], [110], [111], [112], [113], [76], [114], [77], [78], [79], [115], [80], [116], [81], [117], [82], [118], [83], [84], [119], [120], [121], [16], [85], [11], [86], [88], [89], [122], [90], [91]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[26], [70], [80]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[26], [70], [80]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [14], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [16], [85], [11], [86], [87], [88], [89], [90], [91]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [14], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [16], [85], [11], [86], [87], [88], [89], [90], [91]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [14], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [16], [85], [11], [86], [87], [88], [89], [90], [91]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [70], [80]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [70], [80]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [70], [80]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [70], [80]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [70], [80]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[26], [70], [80]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [14], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [16], [85], [11], [86], [87], [88], [89], [90], [91]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[26], [70], [80]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[11], [12], [13]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[11], [12], [13]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [14], [33], [34], [35], [36], [37], [92], [38], [39], [40], [93], [41], [42], [43], [44], [15], [45], [46], [47], [94], [48], [95], [49], [50], [51], [52], [53], [54], [55], [56], [57], [96], [58], [97], [98], [59], [99], [60], [61], [62], [100], [101], [63], [64], [102], [65], [66], [67], [103], [68], [104], [70], [105], [106], [107], [108], [73], [109], [110], [111], [112], [113], [76], [114], [77], [78], [79], [115], [80], [116], [81], [117], [82], [118], [83], [84], [119], [120], [121], [16], [85], [11], [86], [88], [89], [122], [90], [91]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[11], [12], [13]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[11], [12], [13]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [14], [33], [34], [35], [36], [37], [92], [38], [39], [40], [93], [41], [42], [43], [44], [15], [45], [46], [47], [94], [48], [95], [49], [50], [51], [52], [53], [54], [55], [56], [57], [96], [58], [97], [98], [59], [99], [60], [61], [62], [100], [101], [63], [64], [102], [65], [66], [67], [103], [68], [104], [70], [105], [106], [107], [108], [73], [109], [110], [111], [112], [113], [76], [114], [77], [78], [79], [115], [80], [116], [81], [117], [82], [118], [83], [84], [119], [120], [121], [16], [85], [11], [86], [88], [89], [122], [90], [91]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[11], [12], [13]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[11], [12], [13]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[14], [15], [16]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[14], [15], [16]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[11], [12], [13]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[17], [7], [9]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[17], [7], [9]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[17], [7], [9]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[18]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[18]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[18]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[18]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[123], [124]

References
1	Bilgi N, Bell K, Ananthakrishnan AN, Atallah E "Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity." Ann Pharmacother 44 (2010): 926-8. [PMID: 20332334]
2	Ang-Lee MK, Moss J, Yuan CS "Herbal medicines and perioperative care." JAMA 286 (2001): 208-16. [PMID: 11448284]
3	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
4	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
5	Hodges PJ, Kam PC "The peri-operative implications of herbal medicines." Anaesthesia 57 (2002): 889-99. [PMID: 12190754]
6	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
7	Janetzky K, Morreale AP "Probable interaction between warfarin and ginseng." Am J Health Syst Pharm 54 (1997): 692-3. [PMID: 9075501]
8	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
9	Vaes LP, Chyka PA "Interactions of warfarin with garlic, ginger, or ginseng: nature of evidence." Ann Pharmacother 34 (2000): 1478-82. [PMID: 11144706]
10	Yuan CS, Wei G, Dey L, et al. "Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial." Ann Intern Med 141 (2004): 23-7. [PMID: 15238367]
11	Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13. [PMID: 10761967]
12	Vuksan V, Sievenpiper JL, Koo VY, et.al "Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo controlled trial." Arch Intern Med 160 (2000): 1009-13
13	Feldman AZ, Brown FM. Management of Type 1 Diabetes in Pregnancy. Curr Diab Rep. 2016 Aug;16(8):76.
14	Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301. [PMID: 14071924]
15	Field JB, Ohta M, Boyle C, Remer A "Potentiation of acetohexamide hypoglycemia by phenylbutazone." N Engl J Med 277 (1967): 889-94. [PMID: 6061822]
16	Turtle JR, Burgess JA "Hypoglycemic action of fenfluramine in diabetes mellitus." Diabetes 22 (1973): 858-67. [PMID: 4749404]
17	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
18	Becker BN, Greene J, Evanson J, Chidsey G, Stone WJ "Ginseng-induced diuretic resistance." JAMA 276 (1996): 606-7
19	Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]
20	Ahmad S "Drug interaction induces hypoglycemia." J Fam Pract 40 (1995): 540-1. [PMID: 7775905]
21	Ahmad S "Gemfibrozil: interaction with glyburide." South Med J 84 (1991): 102. [PMID: 1898783]
22	Aleyassine H, Gardiner RJ "Dual action of antidepressant drugs (MAO inhibitors) on insulin release." Endocrinology 96 (1975): 702-10. [PMID: 1090438]
23	Aleyassine H, Lee SH "Inhibition of insulin release by substrates and inhibitors of monoamine oxidase." Am J Physiol 222 (1972): 565-9. [PMID: 5022664]
24	Almirall J, Montoliu J, Torras A, Revert L "Propoxyphene-induced hypoglycemia in a patient with chronic renal failure." Nephron 53 (1989): 273-5. [PMID: 2797348]
25	Arauz-Pacheco C, Ramirez LC, Rios JM, Raskin P "Hypoglycemia induced by angiotensin-converting enzyme inhibitors in patients with non-insulin-dependent diabetes receiving sulfonylurea therapy." Am J Med 89 (1990): 811-3. [PMID: 2123605]
26	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]
27	Baciewicz AM, Swafford WB Jr "Hypoglycemia induced by the interaction of chlorpropamide and co-trimoxazole." Drug Intell Clin Pharm 18 (1984): 309-10. [PMID: 6609055]
28	Barbato M "Another problem with Kinidin." Med J Aust 141 (1984): 685. [PMID: 6436654]
29	Baron SH "Salicylates as hypoglycemic agents." Diabetes Care 5 (1982): 64-71. [PMID: 6754304]
30	Ben Salem C, Fathallah N, Hmouda H, Bouraoui K "Drug-induced hypoglycaemia: an update." Drug Saf 34 (2011): 21-45. [PMID: 20942513]
31	Cacoub P, Deray G, Baumelou A, Grimaldi A, Soubrie C, Jacobs C "Disopyramide-induced hypoglycemia: case report and review of the literature." Fundam Clin Pharmacol 3 (1989): 527-35. [PMID: 2691378]
32	Cattaneo AG, Caviezel F, Pozza G "Pharmacological interaction between tolbutamide and acetylsalicylic acid: study on insulin secretion in man." Int J Clin Pharmacol Ther Toxicol 28 (1990): 229-34. [PMID: 2198232]
33	Cooper AJ, Ashcroft G "Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs." Lancet 1 (1966): 407-9. [PMID: 4159787]
34	Croxson MS, Shaw DW, Henley PG, Gabriel HDLL "Disopyramide-induced hypoglycaemia and increased serum insulin." N Z Med J July (1987): 407-8. [PMID: 3330586]
35	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
36	Daubresse JC, Daigneux D, Bruwier M, Luyckx A, Lefebvre PJ "Clofibrate and diabetes control in patients treated with oral hypoglycaemic agents." Br J Clin Pharmacol 7 (1979): 599-603. [PMID: 380614]
37	Daubresse JC, Luyckx AS, Lefebvre PJ "Potentiation of hypoglycemic effect of sulfonylureas by clofibrate." N Engl J Med 294 (1976): 613. [PMID: 1246250]
38	Davis TM, Karbwang J, Looareesuwan S, et al "Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers." Br J Clin Pharmacol 30 (1990): 397-403. [PMID: 2223418]
39	de Salcedo I, Gorringe AL, Silva JL, Santos JA "Gemfibrozil in a group of diabetics." Proc R Soc Med 69 (1976): 64-70. [PMID: 1019155]
40	Deeg MA, Lipkin EW "Hypoglycemia associated with the use of fluoxetine." West J Med 164 (1996): 262-3. [PMID: 8775944]
41	Feher MD, Amiel S "ACE inhibitors and hypoglycaemia." Lancet 346 (1995): 125-6. [PMID: 7603199]
42	Feldman JM, Chapman B "Monoamine oxidase inhibitors: nature of their interaction with rabbit pancreatic islets to alter insulin secretion." Diabetologia 11 (1975): 487-94. [PMID: 1107123]
43	Ferrari C, Fressati S, Romussi M, et al. "Effects of short-term clofibrate administration on glucose tolerance and insulin secretion in patients with chemical diabetes or hypertriglyceridemia." Metabolism 26 (1977): 129-39. [PMID: 834147]
44	Ferriere M, Lachkar H, Richard JL, Bringer J, Orsetti A, Mirouze J "Captopril and insulin sensitivity." Ann Intern Med 102 (1985): 134-5. [PMID: 3881067]
45	Fogari R, Zoppi A, Corradi L, Pierangelo L, Mugellini A, Lusardi P "Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertension." Br J Clin Pharmacol 46 (1998): 467-71. [PMID: 9833600]
46	Giugliano D, Ceriello A, Saccomanno F, et al "Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus." J Clin Endocrinol Metab 61 (1985): 160-6. [PMID: 3923028]
47	Goldberg IJ, Brown LK, Rayfield EJ "Disopyramide (norpace)-induced hypoglycemia." Am J Med 69 (1980): 463-6. [PMID: 6998294]
48	Harrison LC, King-Roach A, Martin FI, Melick RA "The effect of fenfluramine on insulin binding and on basal and insulin-stimulated oxidation of 1-C-glucose by human adipose tissue." Postgrad Med J 51 Suppl 1 (1975): 110-4. [PMID: 1219664]
49	Hayashi S, Horie M, Tsuura Y, Ishida H, Okada Y, Seino Y, Sasayama S "Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release." Am J Physiol 265 (1993): c337-42. [PMID: 8368263]
50	Hekimsoy Z, Biberoglu S, Comlekci A, Tarhan O, Mermut C, Biberoglu K "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." Eur J Endocrinol 136 (1997): 3046. [PMID: 9100556]
51	Hellman B "Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells." Metabolism 23 (1974): 839-46. [PMID: 4212254]
52	Herings RMC, Deboer A, Stricker BHC, Leufkens HGM, Porsius A "Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme." Lancet 345 (1995): 1195-8. [PMID: 7739305]
53	Hundal RS, Petersen KF, Mayerson AB, et al "Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes." J Clin Invest 109 (2002): 1321-6. [PMID: 12021247]
54	Iida H, Morita T, Suzuki E, Iwasawa K, Toyooka T, Nakajima T "Hypoglycemia induced by interaction between clarithromycin and disopyramide." Jpn Heart J 40 (1999): 91-6. [PMID: 10370402]
55	Johnson J, Dobmeier M "Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction." DICP 24 (1990): 250-1. [PMID: 2316232]
56	Johnson JA, Kappel JE, Sharif MN "Hypoglycemia secondary to trimethoprim/sulfamethoxazole administration in a renal transplant patient." Ann Pharmacother 27 (1993): 304-6. [PMID: 8453166]
57	Konttinen A, Kuisma I, Ralli R, Pohjola S, Ojala K "The effect of gemfibrozil on serum lipids in diabetic patients." Ann Clin Res 11 (1979): 240-5. [PMID: 398183]
58	Kubacka RT, Antla EJ, Juhl RP, Welshman IR "Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects." Ann Pharmacother 30 (1996): 20-6. [PMID: 8773160]
59	Morris AD, Newton RW, Boyle DI, et al. "ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes." Diabetes Care 20 (1997): 1363-7. [PMID: 9283780]
60	Murakami K, Nambu S, Koh H, Kobayashi M, Shigeta Y "Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus." Br J Clin Pharmacol 17 (1984): 89-91. [PMID: 6362704]
61	Nakabayashi H, Ito T, Igawa T, Hiraiwa Y, Imamura T, Seta T, Kawato M, Usukura N, Takeda R "Disopyramide induces insulin secretion and plasma glucose diminution: studies using the in situ canine pancreas." Metabolism 38 (1989): 179-83. [PMID: 2643753]
62	Nappi JM, Dhanani S, Lovejoy JR, VanderArk C "Severe hypoglycemia associated with disopyramide." West J Med 138 (1983): 95-7. [PMID: 6404062]
63	Paolisso G, Balbi V, Gambardella A, Varricchio G, Tortoriello R, Saccomanno F, Amato L, Varricchio M "Lisinopril administration improves insulin action in aged patients with hypertension." J Hum Hypertens 9 (1995): 541-6. [PMID: 7562882]
64	Pestell RG, Crock PA, Ward GM, Alford FP, Best JD "Fenfluramine increases insulin action in patients with NIDDM." Diabetes Care 12 (1989): 252-8. [PMID: 2495916]
65	Phillips AF, Matty PJ, Porte PJ, Raye JR "Inhibition of glucose-induced insulin secretion by indomethacin and sodium salicylate in the fetal lamb." Am J Obstet Gynecol 148 (1984): 481-7. [PMID: 6364813]
66	Phillips RE, Looareesuwan S, White NJ, et al "Hypoglycaemia and antimalarial drugs: quinidine and release of insulin." Br Med J 292 (1986): 1319-21. [PMID: 3085830]
67	Pollak PT, Mukherjee SD, Fraser AD "Sertraline-induced hypoglycemia." Ann Pharmacother 35 (2001): 1371-4. [PMID: 11724085]
68	Prince RL, Larkins RG, Alford FP "The effect of acetylsalicylic acid on plasma glucose and the response of glucose regulatory hormones to intravenous glucose and arginine in insulin treated diabetics and normal subjects." Metabolism 30 (1981): 293-8. [PMID: 7010074]
69	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
70	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
71	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
72	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
73	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
74	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
75	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
76	Quevedo SF, Krauss DS, Chazan JA, et al "Fasting hypoglycemia secondary to disopyramide therapy." JAMA 245 (1981): 2424. [PMID: 6785461]
77	Richardson T, Foster J, Mawer GE "Enhancement by sodium salicylate of the blood glucose lowering effect of chlorpropamide-drug interaction or summation of similar effects." Br J Clin Pharmacol 22 (1986): 43-8. [PMID: 3527244]
78	Rubin M, Zakheim B, Pitchumoni C "Disopyramide-induced profound hypoglycemia." N Y State J Med July,Aug,S (1983): 1057-8. [PMID: 6579404]
79	Salmela PI, Sotaniemi EA, Viikari J, et al "Fenfluramine therapy in non-insulin-dependent diabetic patients effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism." Diabetes Care 4 (1981): 535-40. [PMID: 6751729]
80	Semel JD, Wortham E, Karl DM "Fasting hypoglycemia associated with disopyramide." Am Heart J 106 (1983): 1160-1. [PMID: 6356848]
81	Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V "Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia." Eur J Clin Nutr 57 (2003): 243-8. [PMID: 12571655]
82	Slade IH, and Iosefa RN "Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases." J Am Geriatr Soc 15 (1967): 948-50. [PMID: 6046558]
83	Storlien LH, Thorburn AW, Smythe GA, Jenkins AB, Chisholm DJ, Kraegen EW "Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats." Diabetes 38 (1989): 499-503. [PMID: 2647557]
84	Strathman I, Schubert EN, Cohen A, Nitzberg DM "Hypoglycemia in patients receiving disopyramide phosphate." Drug Intell Clin Pharm 17 (1983): 635-8. [PMID: 6413187]
85	Verdy M, Charbonneau L, Verdy I, Belanger R, Bolte E, Chiasson JL "Fenfluramine in the treatment of non-insulin-dependent diabetics: hypoglycemic versus anorectic effect." Int J Obes 7 (1983): 289-97. [PMID: 6629637]
86	Vuksan V, Stavro MP, Sievenpiper JL, et al "Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes." Diabetes Care 23 (2000): 1221-6. [PMID: 10977009]
87	Vuorinen-Markkola H, Yki-Jarvinen H "Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus." Metabolism 44 (1995): 85-9. [PMID: 7854171]
88	Whitcroft IA, Thomas JM, Rawsthorne A, et al "Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics." Horm Metab Res Suppl 22 (1990): 42-6. [PMID: 1975246]
89	Wiederholt IC, Genco M, Foley JM "Recurrent episodes of hypoglycemia induced by propoxyphene." Neurology 17 (1967): 703-6. [PMID: 6067489]
90	World Health Organization "WHO Public Assessment Reports (WHOPARs).".
91	Wu B, Sato T, Kiyosue T, Arita M "Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs." Cardiovasc Res 26 (1992): 1095-101. [PMID: 1291087]
92	David DS, Steere AC Jr, Pi-Sunyer XF, Sakai S, Clark SB "Aspirin-induced hypoglycaemia in a patient on haemodialysis." Lancet 2 (1971): 1092-3. [PMID: 4106934]
93	Diwan PV, Sastry MS, Satyanarayana NV "Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans." Indian J Exp Biol 30 (1992): 317-9. [PMID: 1459600]
94	Harris EL "Adverse reactions to oral antidiabetic agents." Br Med J 3 (1971): 29-30. [PMID: 5091891]
95	Hartmann D, Korn A, Komjati M, Heinz G, Haefelfinger P, Defoin R, Waldhausl WK "Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide." Br J Clin Pharmacol 30 (1990): 245-52. [PMID: 2119677]
96	Kradjan WA, Witt DM, Opheim KE, Wood FC "Lack of interaction between glipizide and co-trimoxazole." J Clin Pharmacol 34 (1994): 997-1002. [PMID: 7836551]
97	Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76. [PMID: 7809177]
98	Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM "Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism." Clin Pharmacol Ther 17 (1975): 731-4. [PMID: 1139863]
99	Morrison PJ, Rogers HJ, Spector RG, Bradbrook ID, John VA "Effect of pirprofen on glibenclamide kinetics and response." Br J Clin Pharmacol 14 (1982): 123-6. [PMID: 6809024]
100	Niemi M, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ, Kivisto KT "Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride." Clin Pharmacol Ther 69 (2001): 194-200. [PMID: 11309547]
101	Nikkila EA, Ylikahri R, Huttunen JK "Gemfibrozil: effect on serum lipids, lipoproteins, postheparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia." Proc R Soc Med 69 (1976): 58-63. [PMID: 190608]
102	Petitpierre B, Perrin L, Rudhardt M, et al "Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy." Int J Clin Pharmacol 6 (1972): 120-4. [PMID: 4638970]
103	Pond SM, Birkett DJ, Wade DN "Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole." Clin Pharmacol Ther 22 (1977): 573-9. [PMID: 913025]
104	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
105	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
106	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
107	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
108	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
109	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
110	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
111	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
112	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
113	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
114	Ravic M, Johnston A, Turner P "Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs." Postgrad Med J 66 (1990): s30-4. [PMID: 2126624]
115	Sawka AM, Burgart V, Zimmerman D "Loss of awareness of hypoglycemia temporally associated with selective serotonin reuptake inhibitors." Diabetes Care 24 (2001): 1845-6. [PMID: 11574457]
116	Shah SJ, Bhandarkar SD, Satoskar RS "Drug interaction between chlorpropamide and non-steroidal anti-flammatory drugs, ibuprofen and phenylbutazone." Int J Clin Pharmacol Ther Toxicol 22 (1984): 470-2. [PMID: 6500764]
117	Sjoberg S, Wiholm BE, Gunnarsson R, Emilsson H, Thunberg E, Christenson I, Ostman J "Lack of pharmacokinetic interaction between glibenclamide and trimethoprim-sulphamethoxazole." Diabet Med 4 (1987): 245-7. [PMID: 2956028]
118	Sone H, Takahashi A, Yamada N "Ibuprofen-related hypoglycemia in a patient receiving sulfonylurea." Ann Intern Med 134 (2001): 344. [PMID: 11182854]
119	Tannenbaum H, Anderson LG, Soeldner JS "Phenylbutazone-tolbutamide drug interaction." N Engl J Med 290 (1974): 344. [PMID: 4809290]
120	Tran PO, Gleason CE, Robertson RP "Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function." Diabetes 51 (2002): 1772-8. [PMID: 12031964]
121	Tremaine LM, Wilner KD, Preskorn SH "A study of the potential effect of sertraline on the pharmacokinetics and protein binding of tolbutamide." Clin Pharmacokinet 32(Suppl 1) (1997): 31-36. [PMID: 9068933]
122	Wing LM, Miners JO "Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition." Br J Clin Pharmacol 20 (1985): 482-5. [PMID: 3878154]
123	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
124	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.

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