Details of Drug-Drug Interaction
| Drug General Information (ID: DDILDA0CR9) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Bumetanide | Drug Info | Ginseng | Drug Info | |||||
| Drug Type | Small molecule | Natural product | |||||||
| Therapeutic Class | Diuretics | Herbal Products | |||||||
| Structure | |||||||||
| Mechanism of Bumetanide-Ginseng Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Bumetanide | Ginseng | |||||||
| Mechanism | Diuretic | Induce diuretic resistance | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacodynamics | ||||||||
| Factor Description | Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Until further data are available, patients treated with furosemide or other loop diuretics should preferably avoid the use of ginseng supplements. The possibility of diuretic resistance should be considered and appropriately monitored if concomitant use is necessary. | ||||||||
| References | |||||||||||||||||||
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| 1 | Becker BN, Greene J, Evanson J, Chidsey G, Stone WJ "Ginseng-induced diuretic resistance." JAMA 276 (1996): 606-7 | ||||||||||||||||||