Drug General Information (ID: DDIFJ9AB1M)
Drug Name			Capreomycin		Drug Info		Etacrynic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Diuretics
Structure

Mechanism of Capreomycin-Etacrynic acid Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Capreomycin				Etacrynic acid
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Capreomycin and Etacrynic acid

Recommended Action
Management		If these drugs must be used together, renal function, auditory and vestibular function, and serum drug concentrations should be monitored.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother 70 (2015): 1903-7. [PMID: 25652747]
3	Product Information. Vancocin (vancomycin). Lilly, Eli and Company, Indianapolis, IN.