Details of Drug

Drug General Information (ID: D0252)
Drug Name	Capreomycin
Drug Type	Small molecule
Drug Synonymous	Capreomycin Sulfate Standard; Capreomycin sulphate; Caprocin (Disulfate); Ogostal (Disulfate); (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(6R)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide; (3S)-3,6-diamino-N-[[(2S,5S,8E,11S,15S)-15-amino-11-[(6R)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]-8-[(carbamoylamino)methylidene]-2-methyl-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]hexanamide Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection; 1B10-1B21: Mycobacterium infection
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C50H88N28O15
InChI	1S/C25H44N14O8.C25H44N14O7/c26-4-1-2-11(27)6-17(41)32-8-14-20(43)35-15(9-34-25(30)47)21(44)39-18(13-3-5-31-24(29)38-13)23(46)33-7-12(28)19(42)37-16(10-40)22(45)36-14;1-11-19(41)36-15(9-32-17(40)7-12(27)3-2-5-26)21(43)37-16(10-34-25(30)46)22(44)39-18(14-4-6-31-24(29)38-14)23(45)33-8-13(28)20(42)35-11/h9,11-14,16,18,40H,1-8,10,26-28H2,(H,32,41)(H,33,46)(H,35,43)(H,36,45)(H,37,42)(H,39,44)(H3,29,31,38)(H3,30,34,47);10-15,18H,2-9,26-28H2,1H3,(H,32,40)(H,33,45)(H,35,42)(H,36,41)(H,37,43)(H,39,44)(H3,29,31,38)(H3,30,34,46)/b15-9+;16-10+/t11-,12-,13+,14-,16-,18-;11-,12-,13-,14+,15-,18-/m00/s1
InChIKey	VCOPTHOUUNAYKQ-WBTCAYNUSA-N
Canonical SMILES	CC1C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)NC(C(=O)NCC(C(=O)N1)N)C2CCN=C(N2)N)CNC(=O)CC(CCCN)N.C1CN=C(NC1C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)N2)CNC(=O)CC(CCCN)N)CO)N)N
External Link
	Pubchem ID	3000502
	CAS Number	11003-38-6
	TTD ID	D0E7MV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM027 Decreased renal excretion due to nephrotoxicity BM045 Additive neuromuscular blocking effects BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM072 Increased risk of nephrotoxicity BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Capreomycin
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[69]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[54]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[58]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[73]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[74]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[13], [14], [78], [79], [80]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[81]
Pharmacodynamic additive effects
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[41], [42], [43], [44]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[41], [42], [43], [44]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[41], [42], [43], [44]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[41], [42], [43], [44]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[41], [42], [43], [44]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[41], [42], [43], [44]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[41], [42], [43], [44]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[41], [42], [43], [44]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[41], [42], [43], [44]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[41], [42], [43], [44]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[41], [42], [43], [44]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[41], [42], [43], [44]
	Increased risk of hypokalemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[49], [50], [51]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[49], [50], [51]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[49], [50], [51]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[49], [50], [51]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[49], [50], [51]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[49], [50], [51]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[49], [50], [51]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[70], [71], [72]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[49], [50], [51]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[49], [50], [51]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[49], [50], [51]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[49], [50], [51]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[49], [50], [51]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[53]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[53]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[53]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[53]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[53]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[53]
	Increased risk of nephrotoxicity					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[8]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[9], [10]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[18], [19], [20]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[21], [22], [23]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[21], [22], [23]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[21], [22], [23]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[24], [25], [26], [27], [28], [29], [30]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[24], [25], [26], [27], [28], [29], [30]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[26], [27], [28]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[24], [25], [26], [27], [28], [29], [30]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[24], [25], [26], [27], [28], [29], [30]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[18], [19], [20]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[18], [19], [20]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[18], [19], [20]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[24], [25], [26], [27], [28], [29], [30]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[21], [22], [23]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[13], [27], [40]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[13], [27], [40]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[13], [27], [40]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[13], [27], [40]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[13], [27], [40]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[45], [46], [47], [48]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[13], [27], [40]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[13], [27], [40]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[52]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[13], [27], [40]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[13], [27], [40]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[55], [56], [57]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[13], [27], [40]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[13], [27], [40]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[59], [60], [61], [56], [62], [63], [64], [65], [66], [67], [57], [68]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[14]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[45], [46], [47], [48]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[13], [27], [40]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[45], [46], [47], [48]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[13], [27], [40]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[59], [60], [61], [56], [62], [63], [64], [65], [66], [67], [57], [68]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[46], [47], [48]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[55], [56], [57]
	Increased risk of ventricular arrhythmias					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[4], [5]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[6], [7]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[11]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[12], [13], [14], [15], [16], [17]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[31], [32], [33]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[34]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[38]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[39]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[13], [14]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[13], [14]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[13], [14]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[13], [14]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[13], [14]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[13], [14]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[13], [14]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[13], [14]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[13], [14]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[14], [82]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[14], [35], [36]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[37]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[75], [76], [77]

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