Drug General Information (ID: DDIHCKFES8)
Drug Name			Furosemide		Drug Info		Etacrynic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Diuretics
Structure

Mechanism of Furosemide-Etacrynic acid Interaction (Severity Level: Major)
Increased risk of ototoxicity Click to Show/Hide Mechanism Graph
Drug Name		Furosemide				Etacrynic acid
Mechanism		Ototoxicity				Ototoxicity
Key Mechanism Factor 1
		Factor Name		Ototoxicity
		Factor Description		Ototoxicity is the damage to the organs of hearing and/or balance following exposure to drugs or chemicals that affect the inner ear. Ototoxic drugs can impair hearing, balance, or both.
Mechanism Description		Increased risk of ototoxicity by the combination of Furosemide and Etacrynic acid

Recommended Action
Management		Concomitant use of furosemide and ethacrynic acid should be avoided.

References
1	Arnold W, Nadol JB Jr, Weidauer H "Ultrastructural histopathology in a case of human ototoxicity due to loop diuretics." Acta Otolaryngol (Stockh) 91 (1981): 399-414. [PMID: 6973908]
2	Product Information. Lasix (furosemide). sanofi-aventis , Bridgewater, NJ.