Details of Drug

Drug General Information (ID: D0067)
Drug Name	Amisulpride
Drug Type	Small molecule
Drug Synonymous	Aminosultopride; Amisulpiride; Amisulprida; Amisulpridum; Deniban; Socian; Solian; Amisulpride [INN]; DAN 2163; Amisulprida [INN-Spanish]; Amisulpride (INN); Amisulpridum [INN-Latin]; DAN-2163; Deniban (TN); Solian (TN); Solian, Amisulpride; SL-91.1077; 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-anisamid; 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide; 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamide; 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide; 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide; 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide Click to Show/Hide
Disease Class	6A20: Schizophrenia
Therapeutic Class	Antipsychotic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H27N3O4S
InChI	1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)
InChIKey	NTJOBXMMWNYJFB-UHFFFAOYSA-N
Canonical SMILES	CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
External Link
	Pubchem ID	2159
	CAS Number	71675-85-9
	CHEBI ID	64045
	TTD ID	D03ELL
	VARIDT ID	DR01259

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM034 Additive antidopaminergic effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM069 Increased risk of lowers seizure threshold BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM093 Antagonize the effect of dopaminergic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Amisulpride
Pharmacodynamic additive effects
	Additive antidopaminergic effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[116], [13], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[177], [178], [179], [180], [181], [182], [183], [184], [185]
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[211], [212], [192], [213], [214], [215], [216], [124], [217], [198], [199], [200], [201], [218], [219], [220]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[244], [3], [13]
	Additive hypotensive effects					Drug Num: 61
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[197], [198], [200]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[197], [198], [200]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[193], [194], [195], [196], [197], [192], [198], [199], [200], [201], [202]
	Increased risk of lowers seizure threshold					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[3], [30], [203]
	Increased risk of prolong QT interval					Drug Num: 152
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1], [10], [11]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[28]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[29]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[13], [3], [30]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[31]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[32]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[34]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[12], [13], [3], [35], [36], [37], [38], [23]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[12], [13], [3], [40]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[12], [13], [3], [41]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1]
D0200		Bretylium	C11H17BrN+	2431	Major		Inter Info	[13], [3], [1]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[44], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[12], [13], [3], [7], [63], [64]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[12], [13], [3], [65], [66], [23], [25]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1], [10], [11]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[1]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [10], [11]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[1], [10], [11]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[12], [13], [3], [67]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[1], [68]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[69]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[13], [3], [1]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[12], [70], [13], [3], [71], [72], [23]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[13], [3], [1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[73], [74], [75], [12], [13], [3], [76], [77], [78], [79], [36], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[74], [12], [13], [3], [95], [96], [97]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[98], [12], [13], [3], [99], [100], [101], [102], [103]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[12], [13], [3], [104], [105], [106], [107], [108], [109], [23]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[44], [3], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[13], [3], [1]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[1]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[12], [13], [3], [110], [23]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[13], [3], [1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[13], [3], [1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [114], [23]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1]
D0948		Lopinavir	C37H48N4O5	92727	Major		Inter Info	[1], [10], [11]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[12], [13], [3], [115], [23]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[13], [3], [1]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[12], [13], [3], [130]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[1]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[73], [74], [75], [12], [13], [3], [76], [77], [78], [79], [36], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[12], [13], [3], [131]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[13], [3], [1]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[140], [141]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[1]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [35], [142], [23]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[13], [3], [1]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[167], [168], [12], [13], [3], [169], [170]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[1]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[12], [13], [3], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[74], [12], [13], [3], [171], [172], [78], [36], [81], [173], [82], [83], [174], [85], [86], [87], [88], [175], [92], [97], [176]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[1]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[12], [13], [3], [186], [35], [187], [188], [189], [23]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[12], [13], [3], [190]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[1]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[12], [13], [3], [191]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[13], [3], [1]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[12], [13], [3], [35], [192], [23]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[13], [3], [223], [224], [225], [226], [227], [196]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[13], [3], [228]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[229], [230]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[13], [3], [201]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[234], [235], [236], [237], [238], [239], [240], [241], [242], [243]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[13], [245], [246], [247]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[12], [13], [3], [248], [249], [250], [251]
	Increased risk of ventricular arrhythmias					Drug Num: 102
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[12], [13], [3], [24], [25]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[3], [26], [27]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[33]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[13], [39]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[42], [43]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[111], [112], [113]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[111], [112], [113]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[3], [1]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[13], [3]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[13], [3]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[13], [3], [206]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[208], [161], [164]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D1231		Patiromer	NA	NA	Moderate		Inter Info	[13], [3]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[12], [221], [222]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[12], [221], [222]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[13], [3], [206]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[12], [221], [222]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[208], [161], [164]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[13], [3]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[13], [3]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[3], [1]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[13], [3]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[13], [3]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[3], [1]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[3], [1]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[13], [3]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[13], [3]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[3], [1]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[13], [3]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[13], [3]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[13], [3]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[3], [1]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[3], [1]
D0492		Digoxin Immune Fab (Ovine)	NA	NA	Moderate		Inter Info	[13], [3]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[3], [1]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[3], [1]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[13], [3]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[13], [3]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[13], [3]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[13], [3]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[13], [3]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[13], [3]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[3], [1]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[12], [13], [3], [204], [205], [206]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[13], [3]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[3], [1]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[3], [1]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[3], [1]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[13], [3]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[3], [1]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[147], [153], [158]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[111], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [208], [209], [155], [156], [157], [158], [159], [210], [160], [112], [161], [162], [163], [164], [113], [165], [166]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[13], [3]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[3], [1]
D1605		Tolevamer	C11H16O3S	58817179	Moderate		Inter Info	[13], [3]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[13], [3]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[3], [1]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[231], [232], [233]
Pharmacodynamic antagonistic effects
	Antagonize the effect of dopaminergic agents					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[13], [3], [1]
D0212		Bromocriptine	C32H40BrN5O5	31101	Major		Inter Info	[13], [3], [1]
D0228		Cabergoline	C26H37N5O2	54746	Major		Inter Info	[13], [3], [1]
D0918		Levodopa	C9H11NO4	6047	Major		Inter Info	[13], [3], [1]
D1255		Pergolide	C19H26N2S	47811	Major		Inter Info	[13], [3], [1]
D1325		Pramipexole	C10H17N3S	119570	Major		Inter Info	[13], [3], [1]
D1427		Ropinirole	C16H24N2O	5095	Major		Inter Info	[13], [3], [1]
D1431		Rotigotine	C19H25NOS	59227	Major		Inter Info	[13], [3], [1]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[211], [212], [192], [213], [214], [215], [216], [124], [217], [198], [199], [200], [201], [218], [219], [220]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[211], [212], [192], [213], [214], [215], [216], [124], [217], [198], [199], [200], [201], [218], [219], [220]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[197], [200], [207]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[197], [200], [207]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[197], [200], [207]

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