Details of Drug-Drug Interaction
| Drug General Information (ID: DDIAJI61RQ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Amisulpride | Drug Info | Rucaparib | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antipsychotic Agents | Poly (Adp-Ribose) Polymerase Inhibitors | |||||||
| Structure | |||||||||
| Mechanism of Amisulpride-Rucaparib Interaction (Severity Level: Major) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Increased risk of ventricular arrhythmias Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Amisulpride | Rucaparib | |||||||
| Mechanism | Prolong QT interval | Bradycardia | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Ventricular arrhythmias | ||||||||
| Factor Description | Ventricular arrhythmias are abnormal heart rhythms that cause your heart's lower chambers to pump blood instead of pumping it. This can limit or stop your heart from supplying blood to your body. While some of these arrhythmias are harmless and do not cause symptoms, others can have serious, even fatal, effects on your body. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Caution and close clinical monitoring (e.g., electrocardiogram, serum electrolytes) are recommended if amisulpride is used in combination with other drugs that can prolong the QT interval. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN. | ||||||||||||||||||