Drug General Information (ID: DDI2PMDVBC)
Drug Name			Pergolide		Drug Info		Amisulpride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiparkinson Agents				Antipsychotic Agents
Structure

Mechanism of Pergolide-Amisulpride Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Pergolide				Amisulpride
Mechanism 1		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Pergolide and Amisulpride
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Pergolide				Amisulpride
Mechanism 2		Dopaminergic agent Dopamine receptor  Agonist				Antidopaminergic effects Dopamine receptor  Antagonist
Key Mechanism Factor 2
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Pergolide when combined with Amisulpride

Recommended Action
Management		Coadministration of amisulpride with levodopa or other dopamine agonists should generally be avoided. If concomitant administration is necessary, patients should be monitored for excessive sedation, hypotension, and potentially diminished therapeutic response to both treatments.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.