Details of Drug

Details of Drug

 Drug General Information (ID: D1255)
  Drug Name
Pergolide
  Drug Type Small molecule
  Drug Synonymous
Pergolida; Pergolidum; Permax; Pergolida [INN-Spanish]; Pergolide (INN); Pergolide [INN:BAN]; Pergolidum [INN-Latin]; Permax (TN); LY-127,809; (6aR,9R,10aR)-9-(Methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline; (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline; (8beta)-8-[(methylthio)methyl]-6-propylergoline
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  Disease Class 8A00: Parkinsonism
  Therapeutic Class Antiparkinson Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H26N2S
  InChI 1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1
  InChIKey YEHCICAEULNIGD-MZMPZRCHSA-N
  Canonical SMILES CCCN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CSC
  External Link
Pubchem ID 47811
CAS Number 66104-22-1
CHEBI ID 63617
TTD ID D04JCN

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM038  Additive CNS depression effects
BM040  Additive dopaminergic effects
BM042  Additive hypotensive effects
BM046  Additive serotonergic effects
BM093  Antagonize the effect of dopaminergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Pergolide
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1825
 
Ioflupane I-123
 
C18H23FINO2
 
3086674 
Moderate    Inter Info   
[36], [8], [40]
      Affected intra/extra-hepatic metabolism
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  210
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0467
 
Dextropropoxyphene
 
C22H29NO2
 
10100 
Major    Inter Info   
[1], [2], [3]
D1485
 
Sodium oxybate
 
C4H7NaO3
 
23663870 
Major    Inter Info   
[10], [11]
D0035
 
Alfentanil
 
C21H32N6O3
 
51263 
Moderate    Inter Info   
[12], [13], [14]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[12], [13], [14]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[12], [13], [14]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[31], [32]
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[33], [5], [34]
D0135
 
Azatadine
 
C20H22N2
 
19861 
Moderate    Inter Info   
[12], [13], [14]
D0137
 
Azelastine (nasal)
 
C22H24ClN3O
 
2267 
Moderate    Inter Info   
[12], [13], [14]
D0143
 
Baclofen
 
C10H12ClNO2
 
2284 
Moderate    Inter Info   
[12], [13], [14]
D0160
 
Benzatropine
 
C21H25NO
 
1201549 
Moderate    Inter Info   
[12], [13], [14]
D0183
 
Biperiden
 
C21H29NO
 
2381 
Moderate    Inter Info   
[12], [13], [14]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[33], [5], [34]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[33], [5], [34]
D0214
 
Brompheniramine
 
C16H19BrN2
 
6834 
Moderate    Inter Info   
[12], [13], [14]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[12], [13], [14]
D0222
 
Buspirone
 
C21H31N5O2
 
2477 
Moderate    Inter Info   
[12], [13], [14]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[12], [13], [14]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[12], [13], [14]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[12], [13], [14]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[12], [13], [14]
D0259
 
Carbinoxamine
 
C16H19ClN2O
 
2564 
Moderate    Inter Info   
[12], [13], [14]
D0263
 
Carisoprodol
 
C12H24N2O4
 
2576 
Moderate    Inter Info   
[12], [13], [14]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[12], [13], [14]
D0318
 
Chlormezanone
 
C11H12ClNO3S
 
2717 
Moderate    Inter Info   
[12], [13], [14]
D0322
 
Chlorphenesin
 
C9H11ClO3
 
7697 
Moderate    Inter Info   
[12], [13], [14]
D0323
 
Chlorpheniramine
 
C16H19ClN2
 
2725 
Moderate    Inter Info   
[12], [13], [14]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0327
 
Chlorzoxazone
 
C7H4ClNO2
 
2733 
Moderate    Inter Info   
[12], [13], [14]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Moderate    Inter Info   
[12], [13], [14]
D0351
 
Clemastine
 
C21H26ClNO
 
26987 
Moderate    Inter Info   
[12], [13], [14]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[12], [13], [14]
D0363
 
Clonidine
 
C9H9Cl2N3
 
2803 
Moderate    Inter Info   
[12], [13], [14]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[12], [13], [14]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0379
 
Codeine
 
C18H21NO3
 
5284371 
Moderate    Inter Info   
[12], [13], [14]
D0397
 
Cyclizine
 
C18H22N2
 
6726 
Moderate    Inter Info   
[12], [13], [14]
D0398
 
Cyclobenzaprine
 
C20H21N
 
2895 
Moderate    Inter Info   
[12], [13], [14]
D0403
 
Cyproheptadine
 
C21H21N
 
2913 
Moderate    Inter Info   
[12], [13], [14]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[12], [13], [14]
D0456
 
Dexbrompheniramine
 
C16H19BrN2
 
16960 
Moderate    Inter Info   
[12], [13], [14]
D0459
 
Dexmedetomidine
 
C13H16N2
 
5311068 
Moderate    Inter Info   
[12], [13], [14]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[12], [13], [14]
D0498
 
Dimenhydrinate
 
C24H28ClN5O3
 
10660 
Moderate    Inter Info   
[12], [13], [14]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[12], [13], [14]
D0504
 
Diphenoxylate
 
C30H32N2O2
 
13505 
Moderate    Inter Info   
[12], [13], [14]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[12], [13], [14]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[12], [13], [14]
D0532
 
Doxylamine
 
C17H22N2O
 
3162 
Moderate    Inter Info   
[12], [13], [14]
D0533
 
Dronabinol
 
C21H30O2
 
16078 
Moderate    Inter Info   
[12], [13], [14]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[12], [13], [14]
D0575
 
Entacapone
 
C14H15N3O5
 
5281081 
Moderate    Inter Info   
[12], [13], [14]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Moderate    Inter Info   
[12], [13], [14]
D0612
 
Eszopiclone
 
C17H17ClN6O3
 
969472 
Moderate    Inter Info   
[12], [13], [14]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[35], [36], [24], [5], [8]
D0618
 
Ethchlorvynol
 
C7H9ClO
 
5281077 
Moderate    Inter Info   
[12], [13], [14]
D0620
 
Ethosuximide
 
C7H11NO2
 
3291 
Moderate    Inter Info   
[12], [13], [14]
D0621
 
Ethotoin
 
C11H12N2O2
 
3292 
Moderate    Inter Info   
[12], [13], [14]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[12], [13], [14]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[12], [13], [14]
D0662
 
Flavoxate
 
C24H25NO4
 
3354 
Moderate    Inter Info   
[12], [13], [14]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Moderate    Inter Info   
[12], [13], [14]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[12], [13], [14]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[12], [13], [14]
D0705
 
Gabapentin
 
C9H17NO2
 
3446 
Moderate    Inter Info   
[12], [13], [14]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Moderate    Inter Info   
[12], [13], [14]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[12], [13], [14]
D0776
 
Hydromorphone
 
C17H19NO3
 
5284570 
Moderate    Inter Info   
[12], [13], [14]
D0781
 
Hydroxyzine
 
C21H27ClN2O2
 
3658 
Moderate    Inter Info   
[12], [13], [14]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[12], [13], [14]
D0890
 
Lamotrigine
 
C9H7Cl2N5
 
3878 
Moderate    Inter Info   
[12], [13], [14]
D0923
 
Levorphanol
 
C17H23NO
 
5359272 
Moderate    Inter Info   
[12], [13], [14]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[12], [13], [14]
D0957
 
Loxapine
 
C18H18ClN3O
 
3964 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0979
 
Maprotiline
 
C20H23N
 
4011 
Moderate    Inter Info   
[12], [13], [14]
D0987
 
Meclizine
 
C25H27ClN2
 
4034 
Moderate    Inter Info   
[12], [13], [14]
D1001
 
Meperidine
 
C15H21NO2
 
4058 
Moderate    Inter Info   
[12], [13], [14]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[12], [13], [14]
D1005
 
Meprobamate
 
C9H18N2O4
 
4064 
Moderate    Inter Info   
[12], [13], [14]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1014
 
Metaxalone
 
C12H15NO3
 
15459 
Moderate    Inter Info   
[12], [13], [14]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[12], [13], [14]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1023
 
Methocarbamol
 
C11H15NO5
 
4107 
Moderate    Inter Info   
[12], [13], [14]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[12], [13], [14]
D1053
 
Metyrosine
 
C10H13NO3
 
441350 
Moderate    Inter Info   
[12], [13], [14]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[12], [13], [14]
D1089
 
Morphine
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[12], [13], [14]
D1090
 
Morphine (liposomal)
 
C17H19NO3
 
5288826 
Moderate    Inter Info   
[12], [13], [14]
D1096
 
Nabilone
 
C24H36O3
 
5284592 
Moderate    Inter Info   
[12], [13], [14]
D1100
 
Nalbuphine
 
C21H27NO4
 
5311304 
Moderate    Inter Info   
[12], [13], [14]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[12], [13], [14]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[12], [13], [14]
D1166
 
Olanzapine
 
C17H20N4S
 
135398745 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[12], [13], [14]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[12], [13], [14]
D1225
 
Paramethadione
 
C7H11NO3
 
8280 
Moderate    Inter Info   
[12], [13], [14]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Moderate    Inter Info   
[12], [13], [14]
D1247
 
Pentazocine
 
C19H27NO
 
441278 
Moderate    Inter Info   
[12], [13], [14]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[12], [13], [14]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[12], [13], [14]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[12], [13], [14]
D0201
 
Brexanolone
 
C21H34O2
 
92786 
Moderate    Inter Info   
[37]
D0208
 
Brivaracetam
 
C11H20N2O2
 
9837243 
Moderate    Inter Info   
[12], [13], [14]
D0212
 
Bromocriptine
 
C32H40BrN5O5
 
31101 
Moderate    Inter Info   
[12], [13], [14]
D0248
 
Cannabidiol
 
C21H30O2
 
644019 
Moderate    Inter Info   
[12], [13], [14]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[12], [13], [14]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[12], [13], [14]
D0311
 
Chloral hydrate
 
C2H3Cl3O2
 
2707 
Moderate    Inter Info   
[12], [13], [14]
D0359
 
Clofedanol
 
C17H20ClNO
 
2795 
Moderate    Inter Info   
[12], [13], [14]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[12], [13], [14]
D0417
 
Dantrolene
 
C14H10N4O5
 
6914273 
Moderate    Inter Info   
[12], [13], [14]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Moderate    Inter Info   
[12], [13], [14]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Moderate    Inter Info   
[12], [13], [14]
D0470
 
Dezocine
 
C16H23NO
 
3033053 
Moderate    Inter Info   
[12], [13], [14]
D0471
 
Diamorphine
 
C21H23NO5
 
5462328 
Moderate    Inter Info   
[12], [13], [14]
D0475
 
Dichloralphenazone
 
C15H18Cl6N2O5
 
10188 
Moderate    Inter Info   
[12], [13], [14]
D0488
 
Difenoxin
 
C28H28N2O2
 
34328 
Moderate    Inter Info   
[12], [13], [14]
D0493
 
Dihydrocodeine
 
C18H23NO3
 
5284543 
Moderate    Inter Info   
[12], [13], [14]
D0600
 
Esketamine
 
C13H16ClNO
 
182137 
Moderate    Inter Info   
[4], [38]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[12], [13], [14]
D0604
 
Estazolam
 
C16H11ClN4
 
3261 
Moderate    Inter Info   
[12], [13], [14]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Moderate    Inter Info   
[12], [13], [14]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Moderate    Inter Info   
[39]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[12], [13], [14]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[12], [13], [14]
D0878
 
Kava
 
C14H16O3
 
5281052 
Moderate    Inter Info   
[41], [42], [43]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[12], [13], [14]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[44]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[12], [13], [14]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[12], [13], [14]
D0912
 
Levetiracetam
 
C8H14N2O2
 
5284583 
Moderate    Inter Info   
[12], [13], [14]
D0940
 
Lithium carbonate
 
CLi2O3
 
11125 
Moderate    Inter Info   
[12], [13], [14]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[12], [13], [14]
D1006
 
Mepyramine
 
C17H23N3O
 
4992 
Moderate    Inter Info   
[12], [13], [14]
D1032
 
Methsuximide
 
C12H13NO2
 
6476 
Moderate    Inter Info   
[12], [13], [14]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[12], [13], [14]
D1182
 
Opicapone
 
C15H10Cl2N4O6
 
135565903 
Moderate    Inter Info   
[12], [13], [14]
D1208
 
Oxymorphone
 
C17H19NO4
 
5284604 
Moderate    Inter Info   
[12], [13], [14]
D1224
 
Paraldehyde
 
C6H12O3
 
31264 
Moderate    Inter Info   
[12], [13], [14]
D1252
 
Pentoxyverine
 
C20H31NO3
 
2562 
Moderate    Inter Info   
[12], [13], [14]
D1253
 
Perampanel
 
C23H15N3O
 
9924495 
Moderate    Inter Info   
[12], [13], [14]
D1264
 
Phenindamine
 
C19H19N
 
11291 
Moderate    Inter Info   
[12], [13], [14]
D1282
 
Phenyltoloxamine
 
C17H21NO
 
7077 
Moderate    Inter Info   
[12], [13], [14]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[12], [13], [14]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[12], [13], [14]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Moderate    Inter Info   
[12], [13], [14]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[12], [13], [14]
D1502
 
St. John's Wort
 
NA
 
NA
Moderate    Inter Info   
[12], [13], [14]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Moderate    Inter Info   
[12], [13], [14]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Moderate    Inter Info   
[12], [13], [14]
D1536
 
Tasimelteon
 
C15H19NO2
 
10220503 
Moderate    Inter Info   
[12], [13], [14]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[12], [13], [14]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Moderate    Inter Info   
[12], [13], [14]
D1675
 
Valerian
 
NA
 
NA
Moderate    Inter Info   
[12], [13], [14]
D1719
 
Ziconotide
 
C102H172N36O32S7
 
16135415 
Moderate    Inter Info   
[12], [13], [14]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1260
 
Phenacemide
 
C9H10N2O2
 
4753 
Moderate    Inter Info   
[12], [13], [14]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[12], [13], [14]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[12], [13], [14]
D1269
 
Phensuximide
 
C11H11NO2
 
6839 
Moderate    Inter Info   
[12], [13], [14]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[12], [13], [14]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1325
 
Pramipexole
 
C10H17N3S
 
119570 
Moderate    Inter Info   
[12], [13], [14]
D1335
 
Pregabalin
 
C8H17NO2
 
5486971 
Moderate    Inter Info   
[12], [13], [14]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[12], [13], [14]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1347
 
Procyclidine
 
C19H29NO
 
4919 
Moderate    Inter Info   
[12], [13], [14]
D1351
 
Promazine
 
C17H20N2S
 
4926 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1355
 
Propiomazine
 
C20H24N2OS
 
4940 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[12], [13], [14]
D1378
 
Ramelteon
 
C16H21NO2
 
208902 
Moderate    Inter Info   
[12], [13], [14]
D1390
 
Remifentanil
 
C20H28N2O5
 
60815 
Moderate    Inter Info   
[12], [13], [14]
D1413
 
Risperidone
 
C23H27FN4O2
 
5073 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1427
 
Ropinirole
 
C16H24N2O
 
5095 
Moderate    Inter Info   
[12], [13], [14]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[12], [13], [14]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Moderate    Inter Info   
[12], [13], [14]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Moderate    Inter Info   
[12], [13], [14]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[12], [13], [14]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[46]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1573
 
Thiopental
 
C11H18N2O2S
 
3000715 
Moderate    Inter Info   
[12], [13], [14]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1578
 
Tiagabine
 
C20H25NO2S2
 
60648 
Moderate    Inter Info   
[12], [13], [14]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[47]
D1604
 
Tolcapone
 
C14H11NO5
 
4659569 
Moderate    Inter Info   
[12], [13], [14]
D1609
 
Topiramate
 
C12H21NO8S
 
5284627 
Moderate    Inter Info   
[12], [13], [14]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Moderate    Inter Info   
[12], [13], [14]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[12], [13], [14]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[12], [13], [14]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1638
 
Triflupromazine
 
C18H19F3N2S
 
5568 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1641
 
Trihexyphenidyl
 
C20H31NO
 
5572 
Moderate    Inter Info   
[12], [13], [14]
D1642
 
Trimethadione
 
C6H9NO3
 
5576 
Moderate    Inter Info   
[12], [13], [14]
D1644
 
Trimethobenzamide
 
C21H28N2O5
 
5577 
Moderate    Inter Info   
[12], [13], [14]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[12], [13], [14]
D1649
 
Tripelennamine
 
C16H21N3
 
5587 
Moderate    Inter Info   
[12], [13], [14]
D1650
 
Triprolidine
 
C19H22N2
 
5282443 
Moderate    Inter Info   
[12], [13], [14]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[12], [13], [14]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[12], [13], [14]
D1694
 
Vigabatrin
 
C6H11NO2
 
5665 
Moderate    Inter Info   
[12], [13], [14]
D1716
 
Zaleplon
 
C17H15N5O
 
5719 
Moderate    Inter Info   
[12], [13], [14]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1729
 
Zolpidem
 
C19H21N3O
 
5732 
Moderate    Inter Info   
[12], [13], [14]
D1730
 
Zonisamide
 
C8H8N2O3S
 
5734 
Moderate    Inter Info   
[12], [13], [14]
   Additive dopaminergic effects Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1492
 
Solriamfetol
 
C10H14N2O2
 
10130337 
Moderate    Inter Info   
[45]
D0998
 
Memantine
 
C12H21N
 
4054 
Minor    Inter Info   
[5], [48]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Major    Inter Info   
[7], [8], [9]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of dopaminergic agents Drug Num:  14
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0067
 
Amisulpride
 
C17H27N3O4S
 
2159 
Major    Inter Info   
[4], [5], [6]
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[19], [23], [29]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0112
 
Asenapine
 
C17H16ClNO
 
3036780 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0202
 
Brexpiprazole
 
C25H27N3O2S
 
11978813 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1046
 
Metoclopramide
 
C14H22ClN3O2
 
4168 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [25], [26], [27], [28], [29], [30]
D1084
 
Molindone
 
C16H24N2O2
 
23897 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1215
 
Paliperidone
 
C23H27FN4O3
 
115237 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
D1576
 
Thiothixene
 
C23H29N3O2S2
 
941651 
Moderate    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30]
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