Drug General Information (ID: DDIIOEMB3R)
Drug Name			Pergolide		Drug Info		Sodium oxybate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiparkinson Agents				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Pergolide-Sodium oxybate Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Pergolide				Sodium oxybate
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Pergolide and Sodium oxybate

Recommended Action
Management		Concomitant use of sodium oxybate with other CNS depressants should be avoided whenever possible. Otherwise, close monitoring and/or dosage reductions should be considered. If short-term use of a CNS depressant is required (e.g., post- or perioperative opioid), a temporary interruption of sodium oxybate therapy may be appropriate.

References
1	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
2	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.