Details of Drug

Drug General Information (ID: D1485)
Drug Name	Sodium oxybate
Drug Type	Small molecule
Drug Synonymous	Sodium oxybate; 502-85-2; Sodium 4-hydroxybutyrate; sodium 4-hydroxybutanoate; Anetamin; Somsanit; Oxybate sodium; 4-Hydroxybutyric acid sodium salt; Gamma OH; Sodium Oxybate [USAN]; Oxybate (sodium); 4-Hydroxybutyrate sodium; Butanoic acid, 4-hydroxy-, monosodium salt; gamma-Hydroxybutyrate sodium; Sodium gamma-hydroxybutyrate; sodium;4-hydroxybutanoate; gamma-Hydroxy sodium butyrate; UNII-7G33012534; WY-3478; EB 27; Hydroxybutyric acid monosodium salt; 4-Hydroxybutyric acid monosodium salt; WY 3478; Sodium oxybate (USAN); Butanoic acid, 4-hydroxy-, sodium salt (1:1); Butanoic acid, 4-hydroxy-, sodium salt; 7G33012534; BUTYRIC ACID, 4-HYDROXY-, SODIUM SALT; Natrium 4-hydroxybutyrat; Sodium-4-hydroxybutyrate; Sodium Oxybutyrate; Sodium Oxybate (Sodium 4-Hydroxybutanoate); NSC-84223; GHB Sodium Salt (Sodium Gammahydroxybutyrate); 4-Hydroxybuttersaeure natriumsalz; gamma-Hydroxybutyrate sodium salt; NCGC00247714-01; EINECS 207-953-3; NSC 84223; gamma-Hydroxybutyric acid, sodium salt; JZP-6; Catabate; Sodium oxybat; SODIUM4-HYDROXYBUTYRATE; Xyrem (TN); GHB; ; ; Sodium oxybate; Sodium gammahydroxybutyrate; DSSTox_CID_28866; DSSTox_RID_83135; DSSTox_GSID_48940; SCHEMBL61823; DEA No. 2012; CHEMBL1200682; DTXSID3048940; HMS2091E15; .gamma.-hydroxybutyrate sodium salt; HY-B1187; Tox21_112871; Gamma Hydroxybutyric Acid preparations; AKOS006221428; CCG-212465; CS-4796; DB09072; CAS-502-85-2; DB-071156; FT-0626615; D05866; H-4040; Butyric acid, 4-hydroxy-, monosodium salt (8CI); Q7553347; Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,rel- Click to Show/Hide
Therapeutic Class	Anxiolytics/Sedatives/Hypnotics
Structure
Structure	3D Structure		2D Structure
Formula	C4H7NaO3
InChI	InChI=1S/C4H8O3.Na/c5-3-1-2-4(6)7;/h5H,1-3H2,(H,6,7);/q;+1/p-1
InChIKey	XYGBKMMCQDZQOZ-UHFFFAOYSA-M
Canonical SMILES	C(CC(=O)[O-])CO.[Na+]
External Link
	Pubchem ID	23663870
	INTEDE ID	DR1494

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM018 Non-CYP450 enzyme inhibition BM038 Additive CNS depression effects BM042 Additive hypotensive effects
Relation Graph

Full list of drugs interacting with Sodium oxybate
Affected intra/extra-hepatic metabolism
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 239
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1], [3]
D0045		Alprazolam	C17H13ClN4	2118	Major		Inter Info	[1], [3]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[3], [1]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[3], [1]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[3], [1]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[3], [1]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[3], [1]
D0135		Azatadine	C20H22N2	19861	Major		Inter Info	[3], [1]
D0143		Baclofen	C10H12ClNO2	2284	Major		Inter Info	[3], [1]
D0208		Brivaracetam	C11H20N2O2	9837243	Major		Inter Info	[3], [1]
D0212		Bromocriptine	C32H40BrN5O5	31101	Major		Inter Info	[3], [1]
D0214		Brompheniramine	C16H19BrN2	6834	Major		Inter Info	[3], [1]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[3], [1]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[3], [1]
D0224		Butabarbital	C10H16N2O3	2479	Major		Inter Info	[1], [2], [3]
D0225		Butalbital	C11H16N2O3	2481	Major		Inter Info	[1], [2], [3]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[1], [2], [3]
D0228		Cabergoline	C26H37N5O2	54746	Major		Inter Info	[3], [1]
D0248		Cannabidiol	C21H30O2	644019	Major		Inter Info	[3], [1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[3], [1]
D0259		Carbinoxamine	C16H19ClN2O	2564	Major		Inter Info	[3], [1]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[3], [1]
D0263		Carisoprodol	C12H24N2O4	2576	Major		Inter Info	[3], [1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[3], [1]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Major		Inter Info	[1], [3]
D0316		Chlorcyclizine	C18H21ClN2	2710	Major		Inter Info	[3], [1]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Major		Inter Info	[1], [3]
D0318		Chlormezanone	C11H12ClNO3S	2717	Major		Inter Info	[3], [1]
D0322		Chlorphenesin	C9H11ClO3	7697	Major		Inter Info	[3], [1]
D0323		Chlorpheniramine	C16H19ClN2	2725	Major		Inter Info	[3], [1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[3], [1]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Major		Inter Info	[3], [1]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[3], [1]
D0351		Clemastine	C21H26ClNO	26987	Major		Inter Info	[3], [1]
D0356		Clobazam	C16H13ClN2O2	2789	Major		Inter Info	[1], [3]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[3], [1]
D0362		Clonazepam	C15H10ClN3O3	2802	Major		Inter Info	[1], [3]
D0363		Clonidine	C9H9Cl2N3	2803	Major		Inter Info	[3], [1]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Major		Inter Info	[1], [3]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3], [1]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[1], [2], [3]
D0397		Cyclizine	C18H22N2	6726	Major		Inter Info	[3], [1]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[3], [1]
D0403		Cyproheptadine	C21H21N	2913	Major		Inter Info	[3], [1]
D0417		Dantrolene	C14H10N4O5	6914273	Major		Inter Info	[3], [1]
D0445		Desflurane	C3H2F6O	42113	Major		Inter Info	[3], [1]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[3], [1]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[3], [1]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Major		Inter Info	[3], [1]
D0459		Dexmedetomidine	C13H16N2	5311068	Major		Inter Info	[1], [3]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[1], [2], [3]
D0471		Diamorphine	C21H23NO5	5462328	Major		Inter Info	[1], [3], [2]
D0473		Diazepam	C16H13ClN2O	3016	Major		Inter Info	[1], [3]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Major		Inter Info	[1], [3]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[1], [3], [2]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Major		Inter Info	[1], [3]
D0502		Diphenhydramine	C17H21NO	3100	Major		Inter Info	[1], [3]
D0503		Diphenhydramine (topical)	C17H21NO	3100	Major		Inter Info	[1], [3]
D0524		Doxazosin	C23H25N5O5	3157	Major		Inter Info	[3], [1]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[3], [1]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [3]
D0532		Doxylamine	C17H22N2O	3162	Major		Inter Info	[1], [3]
D0533		Dronabinol	C21H30O2	16078	Major		Inter Info	[3], [1]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[3], [1]
D0570		Enflurane	C3H2ClF5O	3226	Major		Inter Info	[3], [1]
D0575		Entacapone	C14H15N3O5	5281081	Major		Inter Info	[3], [1]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[3], [1]
D0604		Estazolam	C16H11ClN4	3261	Major		Inter Info	[1], [3]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[1], [3]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1], [3]
D0618		Ethchlorvynol	C7H9ClO	5281077	Major		Inter Info	[1], [3]
D0620		Ethosuximide	C7H11NO2	3291	Major		Inter Info	[1], [3], [2]
D0621		Ethotoin	C11H12N2O2	3292	Major		Inter Info	[3], [1]
D0625		Etomidate	C14H16N2O2	667484	Major		Inter Info	[3], [1]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[3], [1]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[3], [1]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[3], [1]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3]
D0662		Flavoxate	C24H25NO4	3354	Major		Inter Info	[3], [1]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[3], [1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[3], [1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[3], [1]
D0679		Flurazepam	C21H23ClFN3O	3393	Major		Inter Info	[1], [3]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[3], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [3], [2]
D0698		Fospropofol	C13H21O5P	3038498	Major		Inter Info	[1], [3]
D0705		Gabapentin	C9H17NO2	3446	Major		Inter Info	[3], [1]
D0748		Halazepam	C17H12ClF3N2O	31640	Major		Inter Info	[1], [3]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[3], [1]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [3]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[2], [1], [3]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[2], [1], [3]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [3]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[1], [3]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [3]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[3], [1]
D0855		Isoflurane	C3H2ClF5O	3763	Major		Inter Info	[3], [1]
D0879		Ketamine	C13H16ClNO	3821	Major		Inter Info	[3], [1]
D0885		Lacosamide	C13H18N2O3	219078	Major		Inter Info	[3], [1]
D0890		Lamotrigine	C9H7Cl2N5	3878	Major		Inter Info	[3], [1]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1], [3], [2]
D0912		Levetiracetam	C8H14N2O2	5284583	Major		Inter Info	[3], [1]
D0918		Levodopa	C9H11NO4	6047	Major		Inter Info	[3], [1]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[1], [2], [3]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[3], [1]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Major		Inter Info	[1], [3]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[3], [1]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[3], [1]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[3], [1]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[3], [1]
D0987		Meclizine	C25H27ClN2	4034	Major		Inter Info	[3], [1]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[1], [2], [3]
D1003		Mephenytoin	C12H14N2O2	4060	Major		Inter Info	[3], [1]
D1005		Meprobamate	C9H18N2O4	4064	Major		Inter Info	[3], [1]
D1006		Mepyramine	C17H23N3O	4992	Major		Inter Info	[1], [3]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[3], [1]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[2], [1], [3]
D1019		Methdilazine	C18H20N2S	14677	Major		Inter Info	[3], [1]
D1023		Methocarbamol	C11H15NO5	4107	Major		Inter Info	[3], [1]
D1024		Methohexital	C14H18N2O3	9034	Major		Inter Info	[1], [2], [3]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[3], [1]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[3], [1]
D1032		Methsuximide	C12H13NO2	6476	Major		Inter Info	[3], [1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Major		Inter Info	[1], [3], [2]
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[3], [1]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[1], [3]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[3], [1]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[3], [1]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[1], [2], [3]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[1], [3], [2]
D1096		Nabilone	C24H36O3	5284592	Major		Inter Info	[3], [1]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[3], [1]
D1149		Nitrous oxide	N2O	948	Major		Inter Info	[3], [1]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[3], [1]
D1166		Olanzapine	C17H20N4S	135398745	Major		Inter Info	[3], [1]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Major		Inter Info	[1], [3]
D1188		Orphenadrine	C18H23NO	4601	Major		Inter Info	[3], [1]
D1197		Oxazepam	C15H11ClN2O2	4616	Major		Inter Info	[1], [3]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[3], [1]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[1], [2], [3]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[1], [2], [3]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[3], [1]
D1225		Paramethadione	C7H11NO3	8280	Major		Inter Info	[3], [1]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[3], [1]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[1], [2], [3]
D1248		Pentobarbital	C11H18N2O3	4737	Major		Inter Info	[1], [2], [3]
D1253		Perampanel	C23H15N3O	9924495	Major		Inter Info	[3], [1]
D1255		Pergolide	C19H26N2S	47811	Major		Inter Info	[3], [1]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[3], [1]
D1260		Phenacemide	C9H10N2O2	4753	Major		Inter Info	[3], [1]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[3], [1]
D1264		Phenindamine	C19H19N	11291	Major		Inter Info	[3], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [2], [3]
D1269		Phensuximide	C11H11NO2	6839	Major		Inter Info	[3], [1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [3], [2]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [1]
D1325		Pramipexole	C10H17N3S	119570	Major		Inter Info	[3], [1]
D1331		Prazosin	C19H21N5O4	4893	Major		Inter Info	[3], [1]
D1335		Pregabalin	C8H17NO2	5486971	Major		Inter Info	[3], [1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [2], [3]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[3], [1]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[3], [1]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [3]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[1], [3]
D1356		Propofol	C12H18O	4943	Major		Inter Info	[1], [3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [3]
D1367		Quazepam	C17H11ClF4N2S	4999	Major		Inter Info	[1], [3]
D1378		Ramelteon	C16H21NO2	208902	Major		Inter Info	[1], [3]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[2], [1], [3]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [3]
D1427		Ropinirole	C16H24N2O	5095	Major		Inter Info	[1], [3]
D1431		Rotigotine	C19H25NOS	59227	Major		Inter Info	[3], [1]
D1433		Rufinamide	C10H8F2N4O	129228	Major		Inter Info	[3], [1]
D1453		Secobarbital	C12H18N2O3	5193	Major		Inter Info	[1], [2], [3]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[3], [1]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[3], [1]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[3], [1]
D0020		Acrivastine	C22H24N2O2	5284514	Major		Inter Info	[3], [1]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[1], [3], [2]
D0201		Brexanolone	C21H34O2	92786	Major		Inter Info	[3], [1]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[3], [1]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[3], [1]
D0600		Esketamine	C13H16ClNO	182137	Major		Inter Info	[3], [1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[3], [1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[1], [3]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [3]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[1], [2], [3]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Major		Inter Info	[3], [1]
D1183		Opium	NA	NA	Major		Inter Info	[1], [2], [3]
D1224		Paraldehyde	C6H12O3	31264	Major		Inter Info	[1], [3]
D1282		Phenyltoloxamine	C17H21NO	7077	Major		Inter Info	[1], [3]
D1391		Remimazolam	C21H19BrN4O2	9867812	Major		Inter Info	[1], [3]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[3], [1]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[3], [1]
D1675		Valerian	NA	NA	Major		Inter Info	[3], [1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[3], [1]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[1], [2], [3]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[1], [3]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[1], [3]
D1547		Temazepam	C16H13ClN2O2	5391	Major		Inter Info	[1], [3]
D1552		Terazosin	C19H25N5O4	5401	Major		Inter Info	[3], [1]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[3], [1]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[3], [1]
D1572		Thiethylperazine	C22H29N3S2	5440	Major		Inter Info	[3], [1]
D1573		Thiopental	C11H18N2O2S	3000715	Major		Inter Info	[3], [1]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[3], [1]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[3], [1]
D1578		Tiagabine	C20H25NO2S2	60648	Major		Inter Info	[3], [1]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[3], [1]
D1604		Tolcapone	C14H11NO5	4659569	Major		Inter Info	[3], [1]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[3], [1]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[3], [1]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[3], [1]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[1], [3]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[3], [1]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[3], [1]
D1642		Trimethadione	C6H9NO3	5576	Major		Inter Info	[1], [3], [2]
D1644		Trimethobenzamide	C21H28N2O5	5577	Major		Inter Info	[3], [1]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[3], [1]
D1649		Tripelennamine	C16H21N3	5587	Major		Inter Info	[3], [1]
D1650		Triprolidine	C19H22N2	5282443	Major		Inter Info	[3], [1]
D1677		Valproic acid	C8H16O2	3121	Major		Inter Info	[1], [3], [2]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[3], [1]
D1694		Vigabatrin	C6H11NO2	5665	Major		Inter Info	[3], [1]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[3], [1]
D1716		Zaleplon	C17H15N5O	5719	Major		Inter Info	[1], [3]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[3], [1]
D1729		Zolpidem	C19H21N3O	5732	Major		Inter Info	[1], [3]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[3], [1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[7], [8], [2]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[9], [2], [10]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[9], [2], [10]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[9], [2], [10]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[11], [12], [13]
	Additive hypotensive effects					Drug Num: 83
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[4], [5], [6]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[4], [5], [6]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[4], [5], [6]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4], [5], [6]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[4], [5], [6]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[4], [5], [6]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[4], [5], [6]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[4], [5], [6]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[4], [5], [6]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[4], [5], [6]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4], [5], [6]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[4], [5], [6]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[4], [5], [6]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[4], [5], [6]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[4], [5], [6]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[4], [5], [6]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[4], [5], [6]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[4], [5], [6]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[4], [5], [6]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[4], [5], [6]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[4], [5], [6]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4], [5], [6]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[4], [5], [6]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[4], [5], [6]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[4], [5], [6]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[4], [5], [6]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[4], [5], [6]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4], [5], [6]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[4], [5], [6]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[4], [5], [6]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[4], [5], [6]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[4], [5], [6]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[4], [5], [6]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[4], [5], [6]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[4], [5], [6]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[4], [5], [6]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[4], [5], [6]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[4], [5], [6]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4], [5], [6]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[4], [5], [6]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[4], [5], [6]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4], [5], [6]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[4], [5], [6]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[4], [5], [6]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4], [5], [6]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[4], [5], [6]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[4], [5], [6]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[4], [5], [6]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[4], [5], [6]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[4], [5], [6]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[4], [5], [6]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[4], [5], [6]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4], [5], [6]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4], [5], [6]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4], [5], [6]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[4], [5], [6]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[4], [5], [6]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[4], [5], [6]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[4], [5], [6]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[4], [5], [6]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[4], [5], [6]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[4], [5], [6]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[4], [5], [6]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[4], [5], [6]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[4], [5], [6]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [5], [6]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[4], [5], [6]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[4], [5], [6]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[4], [5], [6]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[4], [5], [6]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4], [5], [6]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[4], [5], [6]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[4], [5], [6]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[4], [5], [6]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[4], [5], [6]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[4], [5], [6]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[4], [5], [6]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[4], [5], [6]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[4], [5], [6]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[4], [5], [6]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[4], [5], [6]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[4], [5], [6]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[4], [5], [6]

References
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2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
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8	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
9	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
10	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
11	Product Information. Ifex (ifosfamide). Bristol-Myers Squibb, Princeton, NJ.
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