Drug General Information (ID: DDIZI9NWQM)
Drug Name			Methohexital		Drug Info		Sodium oxybate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Methohexital-Sodium oxybate Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Methohexital				Sodium oxybate
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Methohexital and Sodium oxybate

Recommended Action
Management		Concomitant use of sodium oxybate with other CNS depressants should be avoided whenever possible. Otherwise, close monitoring and/or dosage reductions should be considered. If short-term use of a CNS depressant is required (e.g., post- or perioperative opioid), a temporary interruption of sodium oxybate therapy may be appropriate. All patients treated with sodium oxybate should be advised not to drive, operate machinery, or engage in hazardous activities requiring mental alertness and motor coordination for at least 6 hours after taking the second nightly dose of sodium oxybate and until they know how the medication affects them.

References
1	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.