Details of Drug

Drug General Information (ID: D1024)
Drug Name	Methohexital
Drug Type	Small molecule
Drug Synonymous	Brevital; Brietal; Enallynymall; Enallynymalum; Methodrexitone; Methohexitalum; Methohexitone; Metoesital; Metohexital; Metoesital [DCIT]; Brevital (TN); Methohexital, Monosodium Salt; Methohexitalum [INN-Latin]; Metohexital [INN-Spanish]; Methohexital (USP/INN); Alpha-DL-1-Methyl-5-allyl-5-(1'-methylpentyn-2-yl)barbituricacid; (+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid; 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-(prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione; 1-methyl-5-(1-methylpent-2-yn-1-yl)-5-prop-2-en-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione; 5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Allyl-1-methyl-5-(1-methyl-pent-2-ynyl)-pyrimidine-2,4,6-trione; 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acid; 5-hex-3-yn-2-yl-1-methyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease
Therapeutic Class	Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C14H18N2O3
InChI	1S/C14H18N2O3/c1-5-7-8-10(3)14(9-6-2)11(17)15-13(19)16(4)12(14)18/h6,10H,2,5,9H2,1,3-4H3,(H,15,17,19)
InChIKey	NZXKDOXHBHYTKP-UHFFFAOYSA-N
Canonical SMILES	CCC#CC(C)C1(C(=O)NC(=O)N(C1=O)C)CC=C
External Link
	Pubchem ID	9034
	CAS Number	151-83-7
	CHEBI ID	102216
	TTD ID	D0S8TD

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM026 Increased metabolism (Unspecific) BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM087 Antagonize the effect of antiepileptic agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Methohexital
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[44], [45], [46]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[78]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0676		Fluoxetine	C17H18F3NO	3386	Minor		Inter Info	[76], [77]
	CYP450 enzyme induction					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[12], [13], [14], [15]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[18], [19], [20]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[24], [25], [21], [26], [27], [28], [29], [30], [31]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[32], [33], [21], [10], [34], [35], [36], [37], [38], [39], [40]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[41]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[42], [43]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[18], [19], [20]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[47], [48], [49]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[50], [51], [52], [53]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[18], [19], [20]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[18], [19], [20]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[56], [57], [58]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[18], [19], [20]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[18], [19], [20]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[18], [19], [20]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[59], [60]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[10], [61], [62]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[47], [48], [49]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[47], [48], [49]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[47], [48], [49]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[18], [19], [20]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[69], [70], [71]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[21], [10], [72]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[18], [19], [20]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[73]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[47], [48], [49]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[47], [48], [49]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[59], [60]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[18], [19], [20]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[50], [51], [52], [53]
D0645		Fenoprofen	C15H14O3	3342	Minor		Inter Info	[79], [80]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[81]
D1229		Paroxetine	C19H20FNO3	43815	Minor		Inter Info	[82]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1353		Propafenone	C21H27NO3	4932	Minor		Inter Info	[83]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[63], [64], [65], [66], [67], [68]
	Additive CNS depression effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1], [2], [3], [4], [5]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[9], [10], [11]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[16], [17], [10]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[23]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[54], [55]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[23]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[23]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[23]
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[74], [75]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[6], [7], [8]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[6], [7], [8]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[6], [7], [8]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[6], [7], [8]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[21], [10], [22]
Pharmacodynamic antagonistic effects

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