Drug General Information (ID: DDIUVCOI8W)
Drug Name			Griseofulvin		Drug Info		Methohexital		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antifungal Agents				Anesthetics
Structure

Mechanism of Griseofulvin-Methohexital Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Griseofulvin				Methohexital
Mechanism		Griseofulvin				Decrease the absorption of griseofulvin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Griseofulvin caused by Methohexital

Recommended Action
Management		Patients should be monitored for reduced antifungal efficacy. It may be necessary to increase griseofulvin doses or use alternative therapeutic agents.

References
1	Busfield D, Child KJ, Atkinson RM, Tomich EG "An effect of phenobarbitone on blood-levels of griseofulvin in man." Lancet 2 (1963): 1042-3. [PMID: 14062729]
2	Kraml M, Marton AV, Dvornik D, Chappel C, Garbaczewska L "Effect of primidone (Mysoline) on tissular levels of griseofulvin in the rat." Proc Soc Exp Biol Med 120 (1965): 678-9. [PMID: 5858690]
3	Riegelman S, Rowland M, Epstein WL "Griseofulvin-phenobarbital interaction in man." JAMA 213 (1970): 426-31. [PMID: 5468016]