Details of Drug

Drug General Information (ID: D0741)
Drug Name	Griseofulvin
Drug Type	Small molecule
Drug Synonymous	Amudane; Delmofulvina; Fulcin; Fulcine; Fulvicin; FulvicinUF; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin;Gresfeed; Gricin; Grifulin; Grifulvin; GrisPEG; Grisactin; Griscofulvin; Grisefuline; Griseo; Griseofulvina; Griseofulvine; Griseofulvinum; Griseomix; Griseostatin; Grisetin; Grisofulvin; Grisovin; Grizeofulvin; Grysio; Guservin; Lamoryl; Likuden; Likunden; Murfulvin; Poncyl; Spirofulvin; Sporostatin; Xuanjing; Curling fact or; Curling factor; Fulvican grisactin; Fulvicin U F; Grifulvin V; Gris PEG; Grisactin Ultra; Grise ostatin; Griseofulvin forte; Grisovin FP; Interacts with polymerized microtubules and associated proteins; Sporostatin xan; Biogrisin-FP; FULVICIN P/G 165; FULVICIN P/G 330;Fulvicin Bolus (Veterinary); Fulvicin P/G; Fulvicin U/F; Fulvidex (Veterinary); GRISEOFULVIN, MICROCRYSTALLINE; GRISEOFULVIN, ULTRAMICROCRYSTALLINE; Gris-PEG; Griseofulvin and Alpha-IFN; Griseofulvin-forte; Griseofulvina [INN-Spanish]; Griseofulvine [INN-French]; Griseofulvinum [INN-Latin]; Grisovin (TN); NP-002466; Neo-Fulcin; ULTRAGRIS-165; ULTRAGRIS-330; USAF SC-2; Fulvicin-P/G; Fulvicin-U-F; Fulvicin-U/F; Fulvicin-U/F (Veterinary); Griseofulvin [USAN:INN:BAN:JAN]; (+)-Griseofulvin; 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione Click to Show/Hide
Disease Class	1F28: Dermatophytosis
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H17ClO6
InChI	1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
InChIKey	DDUHZTYCFQRHIY-RBHXEPJQSA-N
Canonical SMILES	CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
External Link
	Pubchem ID	441140
	CAS Number	126-07-8
	CHEBI ID	27779
	TTD ID	D0C1SF
	INTEDE ID	DR0791

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM001 Altered gastrointestinal dynamics BM009 Altered absorption (Unspecific) BM022 CYP450 enzyme induction BM032 Decreased renal excretion (Unspecific) BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions
Relation Graph

Full list of drugs interacting with Griseofulvin
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0936		Liraglutide	C172H265N43O51	16134956	Minor		Inter Info	[356]
	Altered absorption (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[20], [21], [22]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[20], [21], [22]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[20], [21], [22]
D1024		Methohexital	C14H18N2O3	9034	Moderate		Inter Info	[20], [21], [22]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[20], [21], [22]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[20], [21], [22]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[20], [21], [22]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[20], [21], [22]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[20], [21], [22]
D0017		Acetylsalicylic acid	C9H8O4	2244	Minor		Inter Info	[350], [351], [352]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 205
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[3], [6], [10]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[3], [6], [10]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[16], [17]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[18]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[3], [6], [10]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[3], [6], [10]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[3], [6], [10]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[19]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [3], [32], [33], [34], [35], [4], [36], [37], [5], [38], [39], [40], [41], [42], [43], [44], [45], [46], [8], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [10], [58], [11], [12], [13], [59], [60], [61]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[64], [65], [66]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[67], [68], [69]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[31], [70], [71], [72], [55]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[73], [74]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[75]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[76]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[77], [78], [79], [80]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[81]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[64], [100], [101], [65], [66], [102]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[103]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[104]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[105], [106]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[107]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[108], [109]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[67], [68], [110]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[111], [112], [113], [114], [115]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[116]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[68], [117]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[118], [119]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[120]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[121], [122], [123]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[68], [124], [125]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[126], [127]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[128]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[67], [68], [129]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[130]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[131], [132], [133]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[134], [121], [135], [67], [68], [136], [137], [138], [122], [139], [140], [141], [142], [143], [144], [145], [146], [147], [123]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[148]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[149], [150]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[151]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[152], [153], [154], [155], [156], [157], [158], [159]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[160]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[161]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[162]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[163], [68], [164]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[165]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[166]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[167], [168]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[169], [170], [171], [172], [173]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[174]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[175], [176]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[68], [177], [178], [179]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[177], [178], [179]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[180]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[181]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[182], [72]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[183]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[184]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[185]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[186]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[187]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[188]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[67], [68], [69]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[67], [68], [69]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[73], [189]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [3], [32], [33], [34], [35], [4], [36], [37], [5], [38], [39], [40], [41], [42], [43], [44], [45], [46], [8], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [10], [58], [11], [12], [13], [59], [60], [61]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [3], [32], [33], [34], [35], [4], [36], [37], [5], [38], [39], [40], [41], [42], [43], [44], [45], [46], [8], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [10], [58], [11], [12], [13], [59], [60], [61]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[27], [4], [10]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [3], [32], [33], [34], [35], [4], [36], [37], [5], [38], [39], [40], [41], [42], [43], [44], [45], [46], [8], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [10], [58], [11], [12], [13], [59], [60], [61]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[27], [4], [10]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[190]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[191]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[67], [68], [192]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[193]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[134], [121], [135], [67], [68], [136], [137], [138], [122], [139], [140], [141], [142], [143], [144], [145], [146], [147], [123]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[194]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[195]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[105], [106]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[196]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[197]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[198]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[68], [199], [200]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[134], [121], [135], [67], [68], [136], [137], [138], [122], [139], [140], [141], [142], [143], [144], [145], [146], [147], [123]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[201]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[202]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[203], [86], [67], [68], [204], [205]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[207], [208], [213]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[221]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[68], [222]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[223], [224], [225], [226]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[227]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[228]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[67], [68], [229]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[67], [68], [230]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[231]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[67], [232]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[233]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[234]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[67], [68], [235]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[236]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[237]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[238], [239]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[67], [240]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[244], [245]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[246], [247]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[108], [109]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[248]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[249]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[250]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[67], [68], [251]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[134], [121], [135], [67], [68], [136], [137], [138], [122], [139], [140], [141], [142], [143], [144], [145], [146], [147], [123]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[252]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[134], [121], [135], [67], [68], [136], [137], [138], [122], [139], [140], [141], [142], [143], [144], [145], [146], [147], [123]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[253], [254], [255], [256]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[253], [254], [255]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[67], [68], [257]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[258]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[259]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[68], [260]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[68], [261]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[262]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[67], [68], [263]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[266], [67], [267], [268]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[67], [269], [270], [271], [272]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [3], [32], [33], [34], [35], [4], [36], [37], [5], [38], [39], [40], [41], [42], [43], [44], [45], [46], [8], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [10], [58], [11], [12], [13], [59], [60], [61]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[273], [274], [275], [276], [277], [278]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[279]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[280], [281], [282]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[67], [68], [283]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[67], [163], [68], [284]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[67], [285]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[286]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[287]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[288]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[289]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[68], [290]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[291]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[67], [68], [292]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[67], [68], [293], [294]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[295]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[296]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[68], [204], [297]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[67], [68], [298]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[299]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[67], [68], [293], [294]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[68], [300], [301]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[302], [303], [304], [305]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[306]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[307]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[308], [309]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[67], [68], [310]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[86], [68], [311], [312], [313]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[67], [314]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[68], [315]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[316], [67], [68], [303], [317]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[68], [318], [319]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[320]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[321]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[68], [322]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[323]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[324]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[325]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[325]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[326]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[327]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[64], [100], [101], [65], [66], [102]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[328]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[68], [329], [330], [331]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[332], [333]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[334]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[27], [4], [10]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[134], [121], [135], [67], [68], [136], [137], [138], [122], [139], [140], [141], [142], [143], [144], [145], [146], [147], [123]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[67], [68], [69]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[67], [68], [69]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[335], [336], [337], [338]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[86], [67], [68]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[23], [24], [25], [26], [27], [28], [29], [30], [31], [3], [32], [33], [34], [35], [4], [36], [37], [5], [38], [39], [40], [41], [42], [43], [44], [45], [46], [8], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [10], [58], [11], [12], [13], [59], [60], [61]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[27], [4], [10]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[339], [340], [341], [342]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[343]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[325]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[305]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[68], [344], [345], [346], [347]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[348]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[349], [223], [226]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[353]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[354]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[355]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[357]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[358], [359], [360], [361]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[362], [363]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[9], [62], [63]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[67]
	Increased risk of photosensitivity reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[14], [15]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[67], [68], [82]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[67], [241], [14], [242], [243]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[67], [68], [82]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[264], [68], [265]

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92	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
93	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
94	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
95	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
96	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
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106	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
107	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
108	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
109	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
110	Product Information. Coartem (artemether-lumefantrine). Novartis Pharmaceuticals, East Hanover, NJ.
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125	Product Information. Viread (tenofovir). Gilead Sciences, Foster City, CA.
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127	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
128	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
129	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
130	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
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144	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
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161	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
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164	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
165	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
166	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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173	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
174	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
175	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
176	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
177	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
178	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
179	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
180	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
181	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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183	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
184	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
185	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
186	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
187	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
188	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
189	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
190	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
191	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
192	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
193	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
194	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
195	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
196	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
197	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
198	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
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200	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
201	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
202	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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215	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
216	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
217	Hofland KF, Hansen S, Sorensen M, et al. Neoadjuvant bevacizumab and irinotecan versus bevacizumab and temozolomide followed by concomitant chemoradiotherapy in newly diagnosed glioblastoma multiforme: A randomized phase II study.?Acta Oncol. 2014;53(7):939-944. [PMID: 24456504]
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221	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
222	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
223	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
224	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
225	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
226	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
227	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
228	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
229	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
230	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
231	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
232	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
233	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
234	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
235	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
236	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
237	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
238	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
239	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
240	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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242	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
243	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
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246	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
247	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
248	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
249	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
250	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
251	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
252	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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254	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
255	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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257	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
258	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
259	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
260	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
261	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
262	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
263	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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267	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
268	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
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275	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
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279	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
280	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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282	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
283	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
284	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
285	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
286	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
287	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
288	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
289	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
290	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
291	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
292	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
293	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
294	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
295	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
296	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
297	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
298	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
299	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
300	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
301	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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