Drug General Information (ID: DDIYETPVWZ)
Drug Name			Pentobarbital		Drug Info		Griseofulvin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antifungal Agents
Structure

Mechanism of Pentobarbital-Griseofulvin Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Pentobarbital				Griseofulvin
Mechanism		Decrease absorption of griseofulvin				Griseofulvin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Griseofulvin caused by Pentobarbital

Recommended Action
Management		Patients should be monitored for reduced antifungal efficacy. It may be necessary to increase griseofulvin doses or use alternative therapeutic agents.

References
1	Busfield D, Child KJ, Atkinson RM, Tomich EG "An effect of phenobarbitone on blood-levels of griseofulvin in man." Lancet 2 (1963): 1042-3. [PMID: 14062729]
2	Kraml M, Marton AV, Dvornik D, Chappel C, Garbaczewska L "Effect of primidone (Mysoline) on tissular levels of griseofulvin in the rat." Proc Soc Exp Biol Med 120 (1965): 678-9. [PMID: 5858690]
3	Riegelman S, Rowland M, Epstein WL "Griseofulvin-phenobarbital interaction in man." JAMA 213 (1970): 426-31. [PMID: 5468016]