Drug General Information (ID: DDIO70V59Q)
Drug Name			Cyclosporine		Drug Info		Griseofulvin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antifungal Agents
Structure

Mechanism of Cyclosporine-Griseofulvin Interaction (Severity Level: Moderate)
Decreased renal excretion (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Griseofulvin
Mechanism		Cyclosporine				Reduce the serum concentration of cyclosporine
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the excretion of the drug, resulting in changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased renal excretion of Cyclosporine caused by Griseofulvin

Recommended Action
Management		Monitoring of cyclosporine levels during concomitant administration is recommended, as is close observation of the patient for signs of rejection or toxicity when griseofulvin is added to or discontinued from therapy. Dose adjustments may be required.

References
1	Product Information. Grifulvin V (griseofulvan). Ortho Pharmaceuticals, Raritan, NJ. (1992):.
2	Product Information. Fulvicin P/G (griseofulvin). Schering Laboratories, Kenilworth, NJ.
3	Abu-Romeh SH, Rashed A "Ciclosporin A and griseofulvin: another drug interaction." Nephron 58 (1991): 237