Drug General Information (ID: DDIDURZK0Q)
Drug Name			Griseofulvin		Drug Info		Ketoconazole		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antifungal Agents				Antifungal Agents
Structure

Mechanism of Griseofulvin-Ketoconazole Interaction (Severity Level: Moderate)
Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Griseofulvin				Ketoconazole
Mechanism		Hepatotoxicity				Hepatotoxicity
Key Mechanism Factor 1
		Factor Name		Hepatotoxicity
		Factor Description		Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage.
Mechanism Description		Increased risk of hepatotoxicity by the combination of Griseofulvin and Ketoconazole

Recommended Action
Management		It is recommended that treatment with ketoconazole should not be initiated until at least one month after discontinuation of griseofulvin.

References
1	Cerner Multum, Inc. "Australian Product Information.".