Drug General Information (ID: DDIW7XQFA9)
Drug Name			Chloral hydrate		Drug Info		Sodium oxybate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Anxiolytics/Sedatives/Hypnotics
Structure

Mechanism of Chloral hydrate-Sodium oxybate Interaction (Severity Level: Major)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Chloral hydrate				Sodium oxybate
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Chloral hydrate and Sodium oxybate

Recommended Action
Management		The use of sodium oxybate in combination with sedative-hypnotic agents is considered contraindicated.

References
1	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
2	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.