Drug General Information (ID: DDIRANJFOW)
Drug Name			Amisulpride		Drug Info		Oliceridine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Narcotic Analgesics
Structure

Mechanism of Amisulpride-Oliceridine Interaction (Severity Level: Major)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Amisulpride				Oliceridine
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Amisulpride and Oliceridine

Recommended Action
Management		Caution is recommended if oliceridine is used in combination with other drugs that can prolong the QT interval. The daily cumulative dose of oliceridine should not exceed 27 mg. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.

References
1	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.