Details of Drug

Drug General Information (ID: D1645)
Drug Name	Trimethoprim
Drug Type	Small molecule
Drug Synonymous	Abaprim; Alprim; Anitrim; Antrima; Antrimox; Bacdan; Bacidal; Bacide; Bacin; Bacta; Bacterial; Bacticel; Bactin; Bactoprim; Bactramin; Bencole; Bethaprim; Biosulten; Briscotrim; Chemotrin; Cidal; Colizole; Conprim; Cotrimel; Deprim; Duocide; Esbesul; Espectrin; Euctrim; Exbesul; Fermagex; Fortrim; Futin; Idotrim; Ikaprim; Instalac; Kombinax; Lagatrim; Lastrim; Methoprim; Metoprim; Monoprim; Monotrim; Monotrimin; Novotrimel; Omstat; Oraprim; Pancidim; Polytrim; Priloprim; Primosept; Primsol; Proloprim; Protrin; Purbal; Resprim; Roubac; Roubal; Salvatrim; Setprin; Sinotrim; Stopan; Streptoplus; Sugaprim; Sulfamar; Sulfamethoprim; Sulfoxaprim; Sulmeprim; Sulthrim; Sultrex; Syraprim; Tiempe; Toprim; Trimanyl; Trimethioprim; Trimethoprime; Trimethoprimum; Trimethopriom; Trimetoprim; Trimetoprima; Trimexazole; Trimexol; Trimezol; Trimogal; Trimono; Trimopan; Trimpex; Triprim; Trisul; Trisulcom; Trisulfam; Trisural; Uretrim; Urobactrim; Utetrin; Velaten; Wellcoprim; Wellcoprin; Xeroprim; Zamboprim; Bacterial [Antibiotic]; Colizole DS; Component of Bactrim; Component of Septra; Lagatrim Forte; ResprimForte; Septrin DS; Septrin Forte; Septrin S; Trimetoprim [DCIT]; Trimetoprim [Polish]; BW 5672; KUC103659N; NIH 204; T 7883; Trimpex 200; WR 5949; Alcorim-F; Apo-Sulfatrim; BW 56-72; Co-Trimoxizole; Monotrim (TN); NIH 204 (VAN); Proloprim (TN); Smz-Tmp; Sulfamethoxazole & Trimethoprim; TCMDC-125538; Tmp-Ratiopharm; Trimeth/Sulfa; Trimethopim(TMP); Trimethoprim & VRC3375; Trimethoprime [INN-French]; Trimethoprimum [INN-Latin]; Trimetoprima [INN-Spanish]; Trimez-IFSA; Trimpex (TN); Triprim (TN); U-Prin; Uro-D S; BW-56-72; KSC-4-158; AZT + TMP/SMX (mixture) combination; Trimethoprim (JAN/USP/INN); Trimethoprim [USAN:BAN:INN:JAN] Click to Show/Hide
Disease Class	GC08: Urinary tract infection
Therapeutic Class	Antiinfective Agents
Structure
Structure	3D Structure		2D Structure
Formula	C14H18N4O3
InChI	1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
InChIKey	IEDVJHCEMCRBQM-UHFFFAOYSA-N
Canonical SMILES	COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
External Link
	Pubchem ID	5578
	CAS Number	738-70-5
	CHEBI ID	45924
	TTD ID	D0AO5H
	INTEDE ID	DR1648
	VARIDT ID	DR00590

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM026 Increased metabolism (Unspecific) BM028 Competitive inhibition of renal tubular secretion BM032 Decreased renal excretion (Unspecific) BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM058 Increased risk of hyperkalemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM083 Potentiated the pharmacological effects (Unspecific) BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Trimethoprim
Affected cellular transport
	Transporter inhibition					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1], [2], [3]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[51], [52]
D0051		Amantadine	C10H17N	2130	Moderate		Inter Info	[46], [42], [24]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[46], [42], [80]
D0412		Dalfampridine	C5H6N2	1727	Moderate		Inter Info	[46], [42], [84]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[89]
D0998		Memantine	C12H21N	4054	Moderate		Inter Info	[46], [42], [24]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[88]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[53], [46], [54], [42], [55], [56], [57], [58], [59], [60], [24], [61], [62], [63], [64]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[66], [67], [68], [69], [70], [71], [63]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[73]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[56], [57]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[53], [46], [54], [42], [55], [56], [57], [58], [59], [60], [24], [61], [62], [63], [64]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[56], [57]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[90], [91]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[92], [93], [46], [94], [95], [96], [97], [98]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[92], [93], [46]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [71], [108], [63]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[114], [115], [116], [117], [63]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[118]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[120]
	CYP450 enzyme induction					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[81], [82], [83]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[81], [82], [83]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[81], [82], [83]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[81], [82], [83]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[81], [82], [83]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[81], [82], [83]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[81], [82], [83]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1802		Glucarpidase	Zn4+8	21195079	Moderate		Inter Info	[42], [87]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[111], [112], [113]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[42], [65], [121]
D1768		Creatine	C4H9N3O2	586	Minor		Inter Info	[122], [123], [124]
D0491		Digoxin	C41H64O14	2724385	Minor		Inter Info	[125], [126], [127]
D0710		Ganciclovir	C9H13N5O4	135398740	Minor		Inter Info	[46], [42], [132]
D1676		Valganciclovir	C14H22N6O5	135413535	Minor		Inter Info	[46], [42], [132]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[133]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[75], [76], [77], [46], [42], [78]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[75], [76], [77], [46], [42], [78]
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[47], [42], [48]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[74], [42]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[74], [42]
	Increased risk of hyperkalemia					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1170		Olmesartan	C24H26N6O3	158781	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[4], [5], [21], [31], [12], [13], [32], [33], [8], [17], [34], [35], [22], [36], [14], [28], [29], [30], [16], [37], [38], [25], [27], [6], [7], [9], [10], [11], [15], [18], [19], [20], [23], [24], [26]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1631		Triamterene	C12H11N7	5546	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0058		Amiloride	C6H8ClN7O	16231	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0587		Eprosartan	C23H24N2O4S	5281037	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0844		Irbesartan	C25H28N6O	3749	Major		Inter Info	[4], [5], [21], [31], [12], [13], [32], [33], [8], [17], [34], [35], [22], [36], [14], [28], [29], [30], [16], [37], [38], [25], [27], [6], [7], [9], [10], [11], [15], [18], [19], [20], [23], [24], [26]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0954		Losartan	C22H23ClN6O	3961	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1086		Monopotassium phosphate	H2KO4P	516951	Major		Inter Info	[21], [5], [4]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1316		Potassium acetate	C2H3KO2	517044	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1317		Potassium bicarbonate	CHKO3	516893	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1320		Potassium gluconate	C6H11KO7	16760467	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1321		Potassium Iodide	IK	4875	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1322		Potassium perchlorate	ClKO4	516900	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[4], [5], [21], [31], [12], [13], [32], [33], [8], [17], [34], [35], [22], [36], [14], [28], [29], [30], [16], [37], [38], [25], [27], [6], [7], [9], [10], [11], [15], [18], [19], [20], [23], [24], [26]
D1545		Telmisartan	C33H30N4O2	65999	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D1679		Valsartan	C24H29N5O3	60846	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[85], [86]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[119]
	Increased risk of nephrotoxicity					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[46], [42]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[46], [42]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[46], [42]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[46], [42]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[109], [42], [110]
	Increased risk of prolong QT interval					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0149		Bedaquiline	C32H31BrN2O2	5388906	Minor		Inter Info	[77], [46], [42], [128], [129], [130], [131]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[77], [46], [42], [128], [129], [130], [131]
D1682		Vardenafil	C23H32N6O4S	135400189	Minor		Inter Info	[77], [46], [42], [128], [129], [130], [131]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[42], [65]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[42], [43], [44]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[45]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1830		Leucovorin	C20H23N7O7	135403648	Major		Inter Info	[39], [40], [41]
D1832		Levoleucovorin	C20H23N7O7	135398559	Major		Inter Info	[39], [40], [41]
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[42], [49], [50]
D1884		Sapropterin	C9H15N5O3	135398654	Moderate		Inter Info	[46], [72]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[79]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[99], [100], [101]

References
1	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
2	Abel S, Nichols DJ, Brearley CJ, Eve MD "Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide." Br J Clin Pharmacol 49 (2000): 64-71.[PMID: 10606839]
3	Johnson BF, Cheng SL, Venitz J "Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic." J Clin Pharmacol 41 (2001): 1248-56.[PMID: 11697758]
4	Canaday DH, Johnson JR "Hyperkalemia in elderly patients receiving standard doses of trimethoprim-sulfamethoxazole." Ann Intern Med 120 (1994): 438. [PMID: 8304666]
5	Witt JM, Koo JM, Danielson BD "Effect of standard-dose trimethoprim/sulfamethoxazole on the serum potassium concentration in elderly men." Ann Pharmacother 30 (1996): 347-50. [PMID: 8729886]
6	Alappan R, Perazella MA, Buller GK "Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole." Ann Intern Med 124 (1996): 316-20. [PMID: 8554227]
7	Perlmutter EP, Sweeney D, Herskovits G, Kleiner M "Case report: severe hyperkalemia in a geriatric patient receiving standard doses of trimethoprim-sulfamethoxazole." Am J Med Sci 311 (1996): 84-5. [PMID: 8615380]
8	Perazella MA, Mahnensmith RL "Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose." Clin Nephrol 46 (1996): 187-92. [PMID: 8879854]
9	Marinella MA "Trimethoprim-sulfamethoxazole associated with hyperkalemia." West J Med 167 (1997): 356-8. [PMID: 9392994]
10	Hsu I, Wordell CJ "Hyperkalemia and high-dose trimethoprim/sulfamethoxazole." Ann Pharmacother 29 (1995): 427-9. [PMID: 7633023]
11	Antoniou T, Gomes T, Juurlink DN, Loutfy MR, Glazier RH, Mamdani MM "Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study." Arch Intern Med 170 (2010): 1045-9. [PMID: 20585070]
12	Velazquez H, Perazella MA, Wright FS, Ellison DH "Renal mechanism of trimethoprim-induced hyperkalemia." Ann Intern Med 119 (1993): 296-301. [PMID: 8328738]
13	Marinella MA "Reversible hyperkalemia associated with trimethoprim-sulfamethoxazole." Am J Med Sci 310 (1995): 115-7. [PMID: 7668307]
14	Choi MJ, Fernandez PC, Patnaik A, Coupaye-Gerard B, D'Andrea D, Szerlip H, Kleyman TR "Brief report: trimethoprim-induced hyperkalemia in a patient with AIDS." N Engl J Med 328 (1993): 703-6. [PMID: 8433730]
15	Lin SH, Kuo AA, Yu FC, Lin YF "Reversible voltage-dependent distal renal tubular acidosis in a patient receiving standaard doses of trimethoprim-sulphamethoxazole." Nephrol Dial Transplant 12 (1997): 1031-33. [PMID: 9175064]
16	Thomas RJ "Severe hyperkalemia with trimethoprim-quinapril." Ann Pharmacother 30 (1996): 413-4. [PMID: 8729901]
17	Marinella MA "Severe hyperkalemia associated with trimethoprim-sulfamethoxazole and spironolactone." Infect Dis Clin Pract 6 (1997): 256-8.
18	Lawson DH, O'Connor PC, Jick H "Drug attributed alterations in potassium handling in congestive cardiac failure." Eur J Clin Pharmacol 23 (1982): 21-5. [PMID: 7128669]
19	Lawson DH "Adverse reactions to potassium chloride." Q J Med 43 (1974): 433-40. [PMID: 4424028]
20	Perazella MA, Alappan R, Buller GK "Hyperkalemia and trimethoprim-sulfamethoxazole." Ann Intern Med 125 (1996): 1015. [PMID: 8929019]
21	Noto H, Kaneko Y, Takano T, Kurokawa K "Severe hyponatremia and hyperkalemia induced by trimethoprim-sulfamethoxazole in patients with Pneumocystis carinii pneumonia." Intern Med 34 (1995): 96-9. [PMID: 7727887]
22	Greenberg S, Reiser IW, Chou SY, Porush JG. Trimethoprim-sulfamethoxazole induces reversible hyperkalemia.?Ann Intern Med. 1993;119(4):291-295. [PMID: 8328737]
23	Mihm LB, Rathbun RC, Resmantargoff BH "Hyperkalemia associated with high-dose trimethoprim-sulfamethoxazole in a patient with the acquired immunodeficiency syndrome." Pharmacotherapy 15 (1995): 793-7. [PMID: 8602391]
24	Product Information. Bactrim (trimethoprim-sulfamethoxazole). Roche Laboratories, Nutley, NJ.
25	Mori H, Kuroda Y, Imamura S, et al "Hyponatremia and/or hyperkalemia in patients treated with the standard dose of trimethoprim-sulfamethoxazole." Intern Med 42 (2003): 665-9. [PMID: 12924488]
26	Lee SW, Park SW, Kang JM "Intraoperative hyperkalemia induced by administration of trimethoprim-sulfamethoxazole in a patient receiving angiotensin receptor blockers." J Clin Anesth 26 (2014): 427-8. [PMID: 25128254]
27	Perazella MA, Mahnensmith RL "Hyperkalemia in the elderly: drugs exacerbate impaired potassium homeostasis." J Gen Intern Med 12 (1997): 646-56. [PMID: 9346463]
28	Martin J, Mourton S, Nicholls G "Severe hyperkalaemia with prescription of potassium-retaining agents in an elderly patient." N Z Med J 116 (2003): U542. [PMID: 14513088]
29	Modest GA, Price B, Mascoli N "Hyperkalemia in elderly patients receiving standard doses of trimethoprim-sulfamethoxazole." Ann Intern Med 120 (1994): 437. [PMID: 8304664]
30	Perazella MA "Drug-induced hyperkalemia: old culprits and new offenders." Am J Med 109 (2000): 307-14. [PMID: 10996582]
31	Marcy TR, Ripley TL "Aldosterone antagonists in the treatment of heart failure." Am J Health Syst Pharm 63 (2006): 49-58. [PMID: 16373465]
32	Koc M, Bihorac A, Ozener CI, Kantarci G, Akoglu E "Severe hyperkalemia in two renal transplant recipients treated with standard dose of trimethoprim-sulfamethoxazole." Am J Kidney Dis 36 (2000): u59-64. [PMID: 10977811]
33	Bugge JF "Severe hyperkalaemia induced by trimethoprim in combination with an angiotensin-converting enzyme inhibitor in a patient with transplanted lungs." J Intern Med 240 (1996): 249-51. [PMID: 8918517]
34	Smith GW, Cohen SB "Hyperkalaemia and non-oliguric renal failure associated with trimethoprim." Br Med J 308 (1994): 454. [PMID: 8124180]
35	Eiam-Ong S, Kurtzman NA, Sabatini S "Studies on the mechanism of trimethoprim-induced hyperkalemia." Kidney Int 49 (1996): 1372-8. [PMID: 8731102]
36	Fouche R, Bernardin G, Roger PM, Corcelle P, Simler JM, Mattei M "Hyperkaliemia in a patient given high-dose trimethoprim-sulfamethoxazole." Presse Med 25 (1996): 2044. [PMID: 9082385]
37	Pennypacker LC, Mintzer J, Pitner J "Hyperkalemia in elderly patients receiving standard doses of trimethoprim-sulfamethoxazole." Ann Intern Med 120 (1994): 437. [PMID: 8304665]
38	Greenberg S, Reiser IW, Chou SY "Hyperkalemia with high-dose trimethoprim-sulfamethoxazole therapy." Am J Kidney Dis 22 (1993): 603-6. [PMID: 8213804]
39	Bozzette SA, Forthal D, Sattler FR, Kemper C, Richman DD, Tilles JG, Leedom J, Mccutchan JA "The tolerance for zidovudine plus thrice weekly or daily trimethoprim-sulfamethoxazole with and without leucovorin for primary prophylaxis in advanced HIV disease." Am J Med 98 (1995): 177-82. [PMID: 7847434]
40	Product Information. Levoleucovorin (levoleucovorin). Spectrum Chemical, Gardena, CA.
41	Razavi B, Lund B, Allen BL, Schlesinger L "Failure of trimethoprim/sulfamethoxazole prophylaxis for Pneumocystis carinii pneumonia with concurrent leucovorin use." Infection 30 (2002): 41-2. [PMID: 11876516]
42	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
43	UK government "Typhoid.".
44	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
45	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
46	Cerner Multum, Inc. "Australian Product Information.".
47	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
48	Guo LQ, Yamazoe Y "Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines." Acta Pharmacol Sin 25 (2004): 129-36. [PMID: 14769198]
49	Mulenga M, Malunga P, Bennett S. et.al "Folic acid treatment of Zambian children with moderate to severe malaria anemia." Am J Trop Med Hyg 74 (2006): 986-90
50	Product Information. Folic Acid (folic acid). Method Pharmaceuticals, LLC, Arlington, TX.
51	Product Information. Glucophage (metformin). Bristol-Myers Squibb, Princeton, NJ.
52	Somogyi A, Stockley C, Keal J, Rolan P, Bochner F "Reduction of metformin renal tubular secretion by cimetidine in man." Br J Clin Pharmacol 23 (1987): 545-51. [PMID: 3593625]
53	Antoniou T, Gomes T, Mamdani MM, Juurlink DN "Trimethoprim/sulfamethoxazole-induced phenytoin toxicity in the elderly: a population-based study." Br J Clin Pharmacol 71 (2011): 544-9. [PMID: 21395647]
54	Cerner Multum, Inc. "Canadian Product Information.".
55	Dasgupta A, Dennen DA, Dean R, McLawhon RW "Displacement of phenytoin from serum protein carriers by antibiotics: studies with ceftriaxone, nafcillin, and sulfamethoxazole." Clin Chem 37 (1991): 98-100. [PMID: 1988217]
56	Gillman MA "Phenytoin toxicity and co-trimazole." Ann Intern Med 102 (1985): 559. [PMID: 3872091]
57	Hansen JM, Kampmann JP, Siersback-Nielsen K, et al. "The effect of different sulfonamides on phenytoin metabolism in man." Acta Med Scand Suppl 624 (1979): 106-10. [PMID: 284708]
58	Hines LE, Murphy JE "Potentially harmful drug-drug interactions in the elderly: a review." Am J Geriatr Pharmacother 9 (2011): 364-77. [PMID: 22078863]
59	Ilario MJ, Ruiz JE, Axiotis CA "Acute fulminant hepatic failure in a woman treated with phenytoin and trimethoprim-sulfamethoxazole." Arch Pathol Lab Med 124 (2000): 1800-3. [PMID: 11100060]
60	Komatsu T, Yamazaki H, Asahi S, Gillam EMJ, Guengerich FP, Nakajima M, Yokoi T "Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: Roles of cytochromes P4502C9, 2C19, and 3A4." Drug Metab Disposition 28 (2000): 1361-8. [PMID: 11038165]
61	Product Information. Dilantin (phenytoin). Parke-Davis, Morris Plains, NJ.
62	Product Information. Trimethoprim (trimethoprim). Teva Pharmaceuticals USA, North Wales, PA.
63	Wen X, Wang JS, Backman JT, Laitila J, Neuvonen PJ "Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively." Drug Metab Dispos 30 (2002): 631-635. [PMID: 12019187]
64	Wilcox JB "Phenytoin intoxication and cotrimoxazole." N Z Med J 94 (1981): 235-6. [PMID: 6975449]
65	Multum Information Services, Inc. Expert Review Panel.
66	Baldwin SJ, Clarke SE, Chenery RJ "Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone." Br J Clin Pharmacol 48 (1999): 424-32. [PMID: 10510156]
67	Hruska MW, Amico JA, Langaee TY, Ferrell RE, Fitzgerald SM, Frye RF "The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects." Br J Clin Pharmacol 59 (2005): 70-9. [PMID: 15606443]
68	Niemi M, Backman JT, Granfors M, Laitila J, Neuvonen M, Neuvonen PJ "Gemfibrozil considerably increases the plasma concentrations of rosiglitazone." Diabetologia 46 (2003): 1319-23. [PMID: 12898007]
69	Niemi M, Backman JT, Neuvonen PJ "Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone." Clin Pharmacol Ther 76 (2004): 239-49. [PMID: 15371985]
70	Product Information. Avandia (rosiglitazone) SmithKline Beecham, Philadelphia, PA.
71	Scheen AJ "Pharmacokinetic interactions with thiazolidinediones." Clin Pharmacokinet 46 (2007): 1-12. [PMID: 17201456]
72	Product Information. Kuvan (sapropterin). BioMarin Pharmaceutical Inc, Novato, CA.
73	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
74	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
75	Bailey RR "Leukopenia due to a trimethoprim-azathioprine interaction." N Z Med J 97 (1984): 739. [PMID: 6595562]
76	Berg KJ, Gjellestad A, Nordby G, et al "Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients." Nephron 53 (1989): 218-22. [PMID: 2677807]
77	Canadian Pharmacists Association.
78	Product Information. Imuran (azathioprine). Glaxo Wellcome, Research Triangle Park, NC.
79	Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
80	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
81	Bhatia RS, Uppal R, Malhi R, Behera D, Jindal SK "Drug interaction between rifampicin and cotrimazole in patients with tuberculosis." Hum Exp Toxicol 10 (1991): 419-21. [PMID: 1687853]
82	Ribera E, Pou L, Fernandez-Sola A, et al. "Rifampin reduces concentrations of trimethoprim and sulfamethoxazole in serum in human immunodeficiency virus-infected patients." Antimicrob Agents Chemother 45 (2001): 3238-41. [PMID: 11600390]
83	Ribera E, FernandezSola A, Juste C, Rovira A, Romero FJ, ArmadansGil L, Ruiz I, Ocana I, Pahissa A "Comparison of high and low doses of trimethoprim-sulfamethoxazole for primary prevention of toxoplasmic encephalitis in human immunodeficiency virus-infected patients." Clin Infect Dis 29 (1999): 1461-6. [PMID: 10585796]
84	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
85	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
86	Ponce SP, Jennings AE, Madias NE, Harrington JT "Drug-induced hyperkalemia." Medicine (Baltimore) 64 (1985): 357-70. [PMID: 2865667]
87	Product Information. Voraxaze (glucarpidase). BTG International Inc, West Conshohocken, PA.
88	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
89	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
90	Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast." Clin Pharmacol Ther (2010):. [PMID: 20592724]
91	Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
92	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
93	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
94	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
95	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
96	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
97	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
98	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
99	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
100	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
101	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
102	Aquilante CL, Kosmiski LA, Bourne DW, et al. "Impact of the CYP2C8 *3 polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone." Br J Clin Pharmacol 75 (2013): 217-26. [PMID: 22625877]
103	Daily EB, Aquilante CL "Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies." Pharmacogenomics 10 (2009): 1489-510. [PMID: 19761371]
104	Deng LJ, Wang F, Li HD "Effect of gemfibrozil on the pharmacokinetics of pioglitazone." Eur J Clin Pharmacol 61 (2005): 831-6. [PMID: 16283275]
105	Jaakkola T, Backman JT, Neuvonen M, Neuvonen PJ "Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone." Clin Pharmacol Ther 77 (2005): 404-14. [PMID: 15900286]
106	Jaakkola T, Laitila J, Neuvonen PJ, Backman JT "Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors." Basic Clin Pharmacol Toxicol 99 (2006): 44-51. [PMID: 16867170]
107	Product Information. Actos (pioglitazone) Takeda Pharmaceuticals America, Lincolnshire, IL.
108	Totah RA, Rettie AE "Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance." Clin Pharmacol Ther 77 (2005): 341-52. [PMID: 15900280]
109	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
110	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
111	Harron D, Brogden R "Acecaindie (N-acetylprocainamide)." Drugs 39 (1990): 720-40
112	Kosoglou T, Rocci M, Vlasses P "Trimethoprim alters the disposition of procainamide and N-acetylprocainamide." Clin Pharmacol Ther 44 (1988): 467-77
113	Vlasses P, Kosoglou T, Chase S, et al "Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide." Arch Intern Med 149 (1989): 1350-3
114	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
115	Hatorp V "Clinical pharmacokinetics and pharmacodynamics of repaglinide." Clin Pharmacokinet 41 (2002): 471-83. [PMID: 12083976]
116	Niemi M, Kajosaari LI, Neuvonen M, Backman JT, Neuvonen PJ "The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects." Br J Clin Pharmacol 57 (2004): 441-7. [PMID: 15025742]
117	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
118	Product Information. Uptravi (selexipag). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
119	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
120	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
121	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
122	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
123	Goldbart A, Press J, Sofer S, Kapelushnik J "Near fatal acute colchicine intoxication in a child. A case report." Eur J Pediatr 159 (2000): 895-7. [PMID: 11131346]
124	Vandenberghe K, Gosris M, Van Hecke PV, Van Leemputte M, Vangerven L, Hespel P "Long-term creatine intake is beneficial to muscle performance during resistance training." J Appl Physiol 83 (1997): 2055-63. [PMID: 9390981]
125	Becquemont L, Verstuyft C, Kerb R, et al. "Effect of grapefruit juice on digoxin pharmacokinetics in humans." Clin Pharmacol Ther 70 (2001): 311-6. [PMID: 11673746]
126	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
127	Petersen P, Kastrup J, Bartram R, Hansen J "Digoxin-trimethoprim interaction." Acta Med Scand 217 (1985): 423-7
128	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
129	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
130	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
131	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]
132	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
133	Ujhelyi MR, Bottorff MB, Schur M, et al. "Aging effects on the organic basic transporter and stereoselective renal clearance." Clin Pharmacol Ther 62 (1997): 117-28. [PMID: 9284847]

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