Drug General Information (ID: DDIZXAB6OU)
Drug Name			Trimethoprim		Drug Info		Valganciclovir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Antiviral Agents
Structure

Mechanism of Trimethoprim-Valganciclovir Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Trimethoprim				Valganciclovir
Mechanism		Competitive inhibition of renal tubular secretion of ganciclovir				Ganciclovir
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Valganciclovir caused by Trimethoprim mediated competitive inhibition of renal tubular secretion

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.