Drug General Information (ID: DDIS8MELDX)
Drug Name			Creatine		Drug Info		Trimethoprim		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		.				Antiinfective Agents
Structure

Mechanism of Creatine-Trimethoprim Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Creatine				Trimethoprim
Mechanism		Creatine				Competitive inhibition of renal tubular secretion of creatinine
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Creatine caused by Trimethoprim mediated competitive inhibition of renal tubular secretion

References
1	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
2	Goldbart A, Press J, Sofer S, Kapelushnik J "Near fatal acute colchicine intoxication in a child. A case report." Eur J Pediatr 159 (2000): 895-7. [PMID: 11131346]
3	Vandenberghe K, Gosris M, Van Hecke PV, Van Leemputte M, Vangerven L, Hespel P "Long-term creatine intake is beneficial to muscle performance during resistance training." J Appl Physiol 83 (1997): 2055-63. [PMID: 9390981]