Details of Drug

Drug General Information (ID: D1030)
Drug Name	Methoxyflurane
Drug Type	Small molecule
Drug Synonymous	Analgizer; Anecotan; Ingalan; Inhalan; Methofane; Methoflurane; Methofluranum; Methoxane; Methoxiflurane; Methoxifluranum;Methoxyfluoran; Methoxyfluorane; Methoxyfluran; Methoxyfluranum; Metofane; Metossiflurano; Metoxfluran; Metoxifluran; Metoxiflurano; Penthrane; Pentran; Pentrane; Metossiflurano [DCIT]; Methoxyflurane [Anaesthetics, volatile]; Methoxyfluranum [INN-Latin]; Metofane (VAN); Metoxiflurano [INN-Spanish]; Penthrane (TN); Penthrane (VAN); Methoxyflurane (USP/INN); Methoxyflurane [USAN:INN:BAN]; Methyl 1,1-difluoro-2,2-dichloroethyl ether; Ether, 2,2-dichloro-1,1-difluoroethyl methyl; (2,2-dichloro-1,1-difluoroethyl) methyl ether; 2,2-Dichloro-1,1-difluoro-1-methoxyethane; 2,2-Dichloro-1,1-difluoroethyl methyl ether Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease
Therapeutic Class	Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C3H4Cl2F2O
InChI	1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3
InChIKey	RFKMCNOHBTXSMU-UHFFFAOYSA-N
Canonical SMILES	COC(C(Cl)Cl)(F)F
External Link
	Pubchem ID	4116
	CAS Number	76-38-0
	CHEBI ID	6843
	TTD ID	D07SOO
	INTEDE ID	DR1048

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM027 Decreased renal excretion due to nephrotoxicity BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM052 Increased risk of cardiac depression BM072 Increased risk of nephrotoxicity BM076 Increased risk of prolong QT interval BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Methoxyflurane
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[13], [14], [17]
	CYP450 enzyme induction					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[52], [53], [2]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[52], [53], [2]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[52], [53], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[52], [53], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[14], [71]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[52], [53], [2]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[52], [53], [2]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[52], [53], [2]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[52], [53], [2]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[58]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[67]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[13], [14], [68], [69], [70]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[72]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[74]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[75]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[38], [18], [39]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[38], [18], [39]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[38], [18], [39]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[38], [18], [39]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[38], [18], [39]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[38], [18], [39]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[38], [18], [39]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[38], [18], [39]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[38], [18], [39]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[38], [18], [39]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[38], [18], [39]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[38], [18], [39]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[38], [18], [39]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[38], [18], [39]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[38], [18], [39]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[38], [18], [39]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[38], [18], [39]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[38], [18], [39]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[76], [77], [78], [79], [80], [81]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[38], [18], [39]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[38], [18], [39]
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[33], [34]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[59], [60], [61], [14], [45]
	Additive hypertensive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[43], [44]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[13], [14], [73]
	Additive hypotensive effects					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[40], [41], [42]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[13], [50], [51]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[13], [50], [51]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[40], [41], [42]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[13], [50], [51]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[40], [41], [42]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[40], [41], [42]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[13], [50], [51]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[13], [50], [51]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[13], [50], [51]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[62], [63]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[40], [41], [42]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[13], [50], [51]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[13], [50], [51]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[40], [41], [42]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[13], [50], [51]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[40], [41], [42]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[40], [41], [42]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[40], [41], [42]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[13], [50], [51]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[13], [50], [51]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[62], [63]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[13], [50], [51]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[13], [50], [51]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[40], [41], [42]
	Additive neuromuscular blocking effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[54], [55], [56]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[54], [55], [56]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[54], [55], [56]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[54], [55], [56]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[54], [55], [56]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[54], [55], [56]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[54], [55], [56]
	Increased risk of nephrotoxicity					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[1]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Major		Inter Info	[2], [3], [4]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0530		Doxycycline	C22H24N2O8	54671203	Major		Inter Info	[2], [3], [4]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[21], [22], [23]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[24], [25]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[26], [27], [28]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[21], [22], [23]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[21], [22], [23]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[14], [29]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[7], [8], [9]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[7], [8], [9]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[7], [8], [9]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[26], [27], [28]
D1070		Minocycline	C23H27N3O7	54675783	Major		Inter Info	[2], [3], [4]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[26], [27], [28]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[26], [27], [28]
D1564		Tetracycline	C22H24N2O8	54675776	Major		Inter Info	[2], [3], [4]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[14]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[14]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[46], [47], [48], [49]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[14]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[14]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[14]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[57]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[14]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[14]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[14]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[14]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[14]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[14]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[14]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[14]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[14]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[14]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[14]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[14]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[47], [48], [49]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[14]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[14]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[64], [65], [66]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[14]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[14]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[14]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[14]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[14]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[14]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[14]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[46], [47], [48], [49]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[14]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[14]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[14]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[14]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[14]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[14]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[64], [65], [66]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[14]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[14]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[46], [47], [48], [49]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[14]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[14]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[14]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[82], [83], [84], [65], [85], [86], [87], [88], [89], [90], [66], [91]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[12], [13], [14], [15], [16], [17]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0581		Epinephrine	C9H13NO3	5816	Major		Inter Info	[18], [19], [20]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[30], [31], [32]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[30], [31], [32]
D1153		Norepinephrine	C8H11NO3	439260	Major		Inter Info	[35], [36], [37]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[30], [31], [32]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[30], [31], [32]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[13], [14], [45]

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3	Product Information. Declomycin (demeclocycline). Lederle Laboratories, Wayne, NJ.
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23	Product Information. BabyBIG (botulism immune globulin). FFF Enterprises, Temecula, CA.
24	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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