Drug General Information (ID: DDI7QOZAFP)
Drug Name			Methoxyflurane		Drug Info		Streptomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anesthetics				Antibiotics
Structure

Mechanism of Methoxyflurane-Streptomycin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Methoxyflurane				Streptomycin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Methoxyflurane and Streptomycin

Recommended Action
Management		Concomitant use of methoxyflurane with other potentially nephrotoxic agents should generally be avoided. Patients should be advised to seek medical attention if they experience symptoms that may indicate nephrotoxicity such as decreased urine output, sudden weight gain, fluid retention, edema, or shortness of breath.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".