Drug General Information (ID: DDID027G3V)
Drug Name			Atenolol		Drug Info		Methoxyflurane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Anesthetics
Structure

Mechanism of Atenolol-Methoxyflurane Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Atenolol				Methoxyflurane
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Atenolol and Methoxyflurane

Recommended Action
Management		Caution is recommended when cardiac depressant anesthetics are used in patients taking beta blockers. Newer inhalation anaesthetics are generally considered safer. Withdrawing beta-blocker therapy before surgery is not recommended in most patients.

References
1	Product Information. Tenormin (atenolol). ICN Pharmaceuticals Inc, Cost Mesa, CA.
2	Lilja JJ, Raaska K, Neuvonen PJ "Effects of orange juice on the pharmacokinetics of atenolol." Eur J Clin Pharmacol (2005):